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Results for "

fatty acid synthesis

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Fatty Acid Synthase (FASN) (5) Acetyl-CoA Carboxylase (5) Androgen Receptor (1) Antibiotic (4) AP-1 (1) Apoptosis (7) ATP Citrate Lyase (3) Bacterial (6) Biochemical Assay Reagents (21) Cannabinoid Receptor (1) Endogenous Metabolite (14) Ferroptosis (1) Fluorescent Dye (1) Fungal (2) Isotope-Labeled Compounds (3) JNK (1) LXR (2) Phospholipase (1) Reactive Oxygen Species (3)
By Research Areas:	Cancer (9) Endocrinology (1) Infection (8) Inflammation/Immunology (2) Metabolic Disease (25)
Oligonucleotides:	Nucleotides and their Analogs (1)

Inhibitors & Agonists

Screening Libraries

Fluorescent Dye

Biochemical Assay Reagents

Natural
Products

Isotope-Labeled Compounds

Oligonucleotides

Targets Recommended: Free Fatty Acid Receptor Fatty Acid Synthase (FASN) DNA/RNA Synthesis FATP FABP FAAH ELOVL Amino Acid Derivatives Hydroxycarboxylic Acid Receptor (HCAR) Apical Sodium-Dependent Bile Acid Transporter G protein-coupled Bile Acid Receptor 1

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N2078

Yamogenin Neodiosgenin	LXR	Metabolic Disease
Yamogenin (Neodiosgenin) is a diastereomer of diosgenin. Yamogenin (Neodiosgenin) antagonizes the activation of the liver X receptor (LXR) in luciferase ligand assay. Yamogenin (Neodiosgenin) inhibits triacylglyceride (TG) accumulation through the suppression of gene expression of fatty acid synthesis in HepG2 hepatocytes .

HY-W010382

Oxaloacetic acid 2-Oxosuccinic acid	Endogenous Metabolite Reactive Oxygen Species	Metabolic Disease
Oxaloacetic acid (2-Oxosuccinic acid) is a metabolic intermediate involved in several ways, such as citric acid cycle, gluconeogenesis, the urea cycle, the glyoxylate cycle, amino acid synthesis, and fatty acid synthesis, whereby Oxaloacetic acid facilitates the clearance of reactive oxygen species (ROS) and improves mitochondrial function .

HY-D1610

BODIPY FL C5	Fluorescent Dye	Others
BODIPY FL C₅ is a *green fluorescent fatty* acid*. BODIPY FL C₅ can be used as a precursor for the synthesis* of various fluorescent phospholipids. BODIPY FL C₅ is relatively insensitive to the environment and fluoresces in both water-soluble and lipid environments .

HY-B1119

Triclosan 5+ Cited Publications	Bacterial Fungal Antibiotic Apoptosis	Infection Cancer
Triclosan is a broad-spectrum antibacterial agent that inhibits bacterial fatty acid synthesis at the enoyl-acyl carrier protein reductase (FabI) step. Triclosan inhibits E. coli enoyl-acyl carrier protein reductase (FabI) and FabI containing a glycine-to-valine substitution at position 93 (FabIG93V) with IC₅₀s of 2 µM and 10 µM, respectively. Triclosan causes apoptotic effect in cultured rat neural stem cells (NSC). Triclosan exacerbates colitis and colitis-associated colorectal tumorigenesis in animal models .

HY-105900

Ro 22-0654	Others	Metabolic Disease
Ro 22-0654 is a potent lipid synthesis inhibitor. Ro 22-0654 inhibits hepatic fatty acid synthesis and has antiobesity effects .

HY-117142

Quizalofop-P	Acetyl-CoA Carboxylase	Others
Quizalofop-P is absorbed through weed stems and leaves, conducts upward and downward in plants, accumulates at the top and intermediate meristems, inhibits cellular fatty acid synthesis, and makes weeds necrotic. Quizalofop-P is highly selective between grass weeds and dicotyledonous crops .

HY-117142R

Quizalofop-P (Standard)	Acetyl-CoA Carboxylase	Others
Quizalofop-P (Standard) is the analytical standard of Quizalofop-P. This product is intended for research and analytical applications. Quizalofop-P is absorbed through weed stems and leaves, conducts upward and downward in plants, accumulates at the top and intermediate meristems, inhibits cellular fatty acid synthesis, and makes weeds necrotic. Quizalofop-P is highly selective between grass weeds and dicotyledonous crops .

HY-135130

Bischloroanthrabenzoxocinone (-)-BABX	Bacterial	Infection
Bischloroanthrabenzoxocinone is a potent *Type II fatty* acid synthesis (FASII)** inhibitor. Bischloroanthrabenzoxocinone inhibits fatty acid synthesis. Bischloroanthrabenzoxocinone shows antibacterial activities and inhibits phospholipid, DNA, RNA, protein, and cell wall synthesis .

HY-E70278

(9Z-Octadecenyl)-CoA triammonium	Biochemical Assay Reagents	Metabolic Disease
(9Z-Octadecenyl)-CoA triammonium is a coenzyme. (9Z-Octadecenyl)-CoA triammonium is a long-chain acyl-CoA esters. Long-chain acyl-CoA esters are involved in regulation of fatty acid synthesis, enzyme systems, vesicle trafficking, ion channels and ion pumps .

HY-N2078R

Yamogenin (Standard)	LXR	Metabolic Disease
Yamogenin (Standard) is the analytical standard of Yamogenin. This product is intended for research and analytical applications. Yamogenin (Neodiosgenin) is a diastereomer of diosgenin. Yamogenin (Neodiosgenin) antagonizes the activation of the liver X receptor (LXR) in luciferase ligand assay. Yamogenin (Neodiosgenin) inhibits triacylglyceride (TG) accumulation through the suppression of gene expression of fatty acid synthesis in HepG2 hepatocytes .

HY-B1119R

Triclosan (Standard)	Bacterial Fungal Antibiotic Apoptosis	Infection Cancer
Triclosan (Standard) is the analytical standard of Triclosan. This product is intended for research and analytical applications. Triclosan is a broad-spectrum antibacterial agent that inhibits bacterial fatty acid synthesis at the enoyl-acyl carrier protein reductase (FabI) step. Triclosan inhibits E. coli enoyl-acyl carrier protein reductase (FabI) and FabI containing a glycine-to-valine substitution at position 93 (FabIG93V) with IC₅₀s of 2 µM and 10 µM, respectively. Triclosan causes apoptotic effect in cultured rat neural stem cells (NSC). Triclosan exacerbates colitis and colitis-associated colorectal tumorigenesis in animal models .

HY-144701

SABA1	Antibiotic Bacterial	Infection Inflammation/Immunology
SABA1 possesses antibacterial properties against Pseudomonas aeruginosa and Escherichia coli, with an IC₅₀ of 4.0 µM against E. coli ACC .

HY-126912A

Lauroyl coenzyme A lithium	Biochemical Assay Reagents Endogenous Metabolite	Others
Lauroyl coenzyme A lithium salt is an intermediary in fatty acid synthesis or metabolism, formed by combining long-chain fatty acids (or lauric acid) with coenzyme A. Lauroyl coenzyme A lithium salt is involved in lipid biosynthesis and fatty acid transport, in which coenzyme A acts as a transport molecule to help move and target specific compounds.

HY-113427

trans-Vaccenic acid	Endogenous Metabolite	Others
trans-Vaccenic acid is a precursor for the synthesis of saturated fatty acid in the rumen and of conjugated linoleic acid (CLA) at the tissue level.

HY-E70256

12:0 Coenzyme A Lauroyl coenzyme A triammonium	Biochemical Assay Reagents Endogenous Metabolite	Others
12:0 Coenzyme A (Lauroyl coenzyme A triammonium) is an intermediary in fatty acid synthesis or metabolism, formed by combining long-chain fatty acids (or lauric acid) with coenzyme A. 12:0 Coenzyme A is involved in lipid biosynthesis and fatty acid transport, in which coenzyme A acts as a transport molecule to help move and target specific compounds .

HY-B0511

Biotin Maximum Cited Publications 10 Publications Verification Vitamin B7; Vitamin H; D-Biotin	Endogenous Metabolite	Metabolic Disease
Biotin, vitamin B7 and serves as a coenzyme for five carboxylases in humans, involved in the synthesis of fatty acids, isoleucine, and valine, and in gluconeogenesis. Biotin is necessary for cell growth, the production of fatty acids, and the metabolism of fats and amino acids .

HY-110028

Leelamine hydrochloride	Cannabinoid Receptor Fatty Acid Synthase (FASN) Androgen Receptor	Endocrinology Cancer
Leelamine hydrochloride is a tricyclic diterpene molecule that is extracted from the bark of pine trees . Leelamine hydrochloride is a cannabinoid receptor type 1 (CB1) agonist and a inhibitor of SREBP1-regulated **fatty acid/lipid synthesis in prostate cancer cells that is not affected by androgen receptor status. Leelamine hydrochloride suppresses transcriptional activity of androgen receptor*, which is known to regulate fatty* acid synthesis ^[2,3].

HY-B0511A

Biotin sodium Vitamin B7 sodium; Vitamin H sodium; D-Biotin sodium	Endogenous Metabolite	Metabolic Disease
Biotin (Vitamin B7) sodium is a water-soluble B vitamin and serves as a coenzyme for five carboxylases in humans, involved in the synthesis of fatty acids, isoleucine, and valine, and in gluconeogenesis. Biotin sodium is necessary for cell growth, the production of fatty acids, and the metabolism of fats and amino acids .

HY-127139

Eicosapentaenoyl Chloride Eicosapentaenoic acid Chloride; EPA Chloride	Endogenous Metabolite	Metabolic Disease
Eicosapentaenoyl chloride is a derivative of eicosapentaenoic acid. It has been used in the synthesis of fatty acid conjugates to enhance lipophilicity and cell permeability of bioactive compounds such as (–)-epigallocatechin gallate and salicylic acid.

HY-B0511R

Biotin (Standard) Vitamin B7 (Standard); Vitamin H (Standard); D-Biotin (Standard)	Endogenous Metabolite	Metabolic Disease
Biotin (Standard) is the analytical standard of Biotin. Biotin, vitamin B7 and serves as a coenzyme for five carboxylases in humans, involved in the synthesis of fatty acids, isoleucine, and valine, and in gluconeogenesis. Biotin is necessary for cell growth, the production of fatty acids, and the metabolism of fats and amino acids .

HY-W010382S

Oxaloacetic acid-13C4 2-Oxosuccinic acid-¹³C₄	Endogenous Metabolite Isotope-Labeled Compounds	Metabolic Disease
Oxaloacetic acid- ¹³C₄ is the ¹³C-labeled Oxaloacetic acid. Oxaloacetic acid (2-Oxosuccinic acid) is a metabolic intermediate involved in several ways, such as citric acid cycle, gluconeogenesis, the urea cycle, the glyoxylate cycle, amino acid synthesis, and fatty acid synthesis[1][2][3].

HY-W018392

Mono-(2-ethylhexyl) phthalate 5+ Cited Publications MEHP; Phthalic acid mono-2-ethylhexyl ester	Endogenous Metabolite	Metabolic Disease
Mono-(2-ethylhexyl) phthalate (MEHP) is a major bioactive metabolite of diethylhexyl phthalate (DEHP). Mono-(2-ethylhexyl) phthalate can promote fatty acid synthesis in hepatocytes by regulating the expression of relevant genes and proteins, contributing to non-alcoholic fatty liver disease (NAFLD) .

HY-W048449

L-Biotin	Others	Metabolic Disease
L-Biotin, also known as biotin, is a water-soluble vitamin that is an essential cofactor in the carboxylation of several enzymes. L-Biotin is involved in fatty acid synthesis and amino acid metabolism .

HY-136373

Metazachlor	Others	Others
Metazachlor is a herbicide of the chloroacetamide class. Metazachlor is an inhibitor of the synthesis of long chain fatty acids and has an effect on cell division or tissue differentiation in the germinating and emerging weed target species .

HY-W669241

Dimethenamide-P	Others	Others
Dimethenamide-P is an amide herbicide effective for the pre-emergence management of annual grasses, small-seeded broadleaf weeds, and sedges in ornamental plants, functioning by inhibiting the synthesis of long-chain fatty acids.

HY-122394

Thiolactomycin	Antibiotic Bacterial	Infection
Thiolactomycin is an antibiotic. Thiolactomycin is active against Gram-negative anaerobes. Thiolactomycin also inhibits malaria and trypanosomes. Thiolactomycin is a FabB inhibitor. Thiolactomycin inhibits the synthesis of fatty acids and mycolic acids .

HY-121423

Dimethachlor	Apoptosis Reactive Oxygen Species	Metabolic Disease
Dimethachlor, a synthetic herbicide, inhibits the undesirable growth of weeds via the suppression of very long-chain fatty acid synthesis. Dimethachlor disrupts normal developmental processes via the induction of apoptosis and ROS production .

HY-15259A

CP-640186 hydrochloride 5+ Cited Publications	Acetyl-CoA Carboxylase	Metabolic Disease
CP-640186 hydrochloride is an orally active and cell-permeable Acetyl-CoA carboxylase (ACC) inhibitor with IC₅₀s of 53 nM and 61 nM for rat liver ACC1 and rat skeletal muscle ACC2 respectively. Acetyl-CoA carboxylase (ACC) is a key enzyme of fatty acid metabolism that enables the synthesis of malonyl-CoA. CP-640186 hydrochloride can also stimulate muscle fatty acid oxidation .

HY-15259

CP-640186 5+ Cited Publications	Acetyl-CoA Carboxylase	Metabolic Disease
CP-640186 is an orally active and cell-permeable Acetyl-CoA carboxylase (ACC) inhibitor with IC₅₀s of 53 nM and 61 nM for rat liver ACC1 and rat skeletal muscle ACC2 respectively. Acetyl-CoA carboxylase (ACC) is a key enzyme of fatty acid metabolism that enables the synthesis of malonyl-CoA. CP-640186 can also stimulate muscle fatty acid oxidation .

HY-16007

(-)-Hydroxycitric acid Garcinia acid	ATP Citrate Lyase	Metabolic Disease
(-)-Hydroxycitric acid (Garcinia acid) is the principal acid of fruit rinds of Garcinia cambogia. (-)-Hydroxycitric acid is a potent and competitive and orally active inhibitor of ATP citrate lyase. (-)-Hydroxycitric acid suppresses the fatty acid synthesis, lipogenesis, food intake, and induced weight loss .

HY-W127342

Decanoyl chloride Decanoic acid chloride	Biochemical Assay Reagents	Others
Decanoyl chloride is an organic compound belonging to the class of acid chlorides. It is a colorless liquid with a pungent odor and is commonly used as a reagent in various organic chemical reactions, especially in the synthesis of esters, amides and fatty acids. Decanoyl chloride has numerous applications in synthetic organic chemistry, especially in the production of pharmaceuticals, agrochemicals and specialty chemicals. In addition, it can be used as a precursor for the synthesis of surfactants and detergents.

HY-123307

Quizalofop Xylafop	Acetyl-CoA Carboxylase	Others
Quizalofop (Xylafop) is a herbicide that inhibits acetyl-CoA carboxylase (ACCase) to reduce the synthesis of fatty acids. Quizalofop can be used to screen EMS (HY-W015854) mutated microalgae for research on improving the performance of microalgae biofuel production .

HY-W018392S

Mono-(2-ethylhexyl) phthalate-d4 MEHP-d₄; Phthalic acid mono-2-ethylhexyl ester-d₄	Isotope-Labeled Compounds	Metabolic Disease
Mono-(2-ethylhexyl) phthalate-d₄ is a deuterium labeled Mono-(2-ethylhexyl) phthalate (HY-W018392). Mono-(2-ethylhexyl) phthalate (MEHP) is a major bioactive metabolite of diethylhexyl phthalate (DEHP). Mono-(2-ethylhexyl) phthalate can promote fatty acid synthesis in hepatocytes by regulating the expression of relevant genes and proteins, contributing to non-alcoholic fatty liver disease (NAFLD) .

HY-W018392R

Mono-(2-ethylhexyl) phthalate (Standard)	Endogenous Metabolite	Metabolic Disease
Mono-(2-ethylhexyl) phthalate (Standard) is the analytical standard of Mono-(2-ethylhexyl) phthalate. This product is intended for research and analytical applications. Mono-(2-ethylhexyl) phthalate (MEHP) is a major bioactive metabolite of diethylhexyl phthalate (DEHP). Mono-(2-ethylhexyl) phthalate can promote fatty acid synthesis in hepatocytes by regulating the expression of relevant genes and proteins, contributing to non-alcoholic fatty liver disease (NAFLD) .

HY-N2486

Desoxyrhaponticin 1 Publications Verification	Fatty Acid Synthase (FASN) Apoptosis	Cancer
Desoxyrhaponticin is a kind of oral drug that inhibits effective fatty acid synthesis (FASN), and has a fatal effect on cancer cells. Desoxyrhaponticin has the ability to inhibit glucose uptake, improve oral glucose tolerance as a diabetic agent, and possess anti-diabetic effects .

HY-W127423

Methyl 2-hydroxyoctadecanoate	Biochemical Assay Reagents	Others
Methyl (+/-)-2-hydroxystearateis a hydroxylated fatty acid methyl ester that broadens phase transitions in dimyristoylphosphatidylcholine (DMPC) lipid membranes. It has been used in the synthesis of lipid-nucleotide conjugated anti-HIV agents to increase the cleavage of phosphodiester bonds and the number of released intracellular nucleotides.

HY-B0276A

Ethionamide hydrochloride 2-Ethylthioisonicotinamide hydrochloride	Others	Infection
Ethionamide hydrochloride (2-Ethylthioisonicotinamide hydrochloride) is an antituberculosis drug with mycobacterial activity. Ethionamide hydrochloride interferes with the bacterial cell wall synthesis process by inhibiting the synthesis of fatty acids in the bacterial cell wall. Ethionamide hydrochloride may have bacteriostatic or bactericidal effects, depending on the concentration of the drug at the site of infection and the susceptibility of the associated microorganisms. Ethionamide hydrochloride combines with NAD+ to form an adduct, thereby exerting its antibacterial effect .

HY-136373R

Metazachlor (Standard)	Others	Others
Metazachlor (Standard) is the analytical standard of Metazachlor. This product is intended for research and analytical applications. Metazachlor is a herbicide of the chloroacetamide class. Metazachlor is an inhibitor of the synthesis of long chain fatty acids and has an effect on cell division or tissue differentiation in the germinating and emerging weed target species .

HY-120394

TVB-3166 5+ Cited Publications	Fatty Acid Synthase (FASN) Apoptosis	Cancer
TVB-3166 is an orally-available, reversible, and selective fatty acid synthase (FASN) inhibitor with IC₅₀s of 42 nM and 81 nM for biochemical FASN and cellular palmitate synthesis, respectively. TVB-3166 induces apoptosis, and inhibits in-vivo xenograft tumor growth .

HY-120062

TVB-3664 1 Publications Verification	Fatty Acid Synthase (FASN)	Cancer
TVB-3664 is an orally available, reversible, potent, selective and highly bioavailable fatty acid synthase (FASN) inhibitor, with IC₅₀ values of 18 nM and 12 nM for human and mouse cell palmitate synthesis, respectively. TVB-3664 significantly reduces tubulin palmitoylation and mRNA expression .

HY-121423R

Dimethachlor (Standard)	Apoptosis Reactive Oxygen Species	Metabolic Disease
Dimethachlor (Standard) is the analytical standard of Dimethachlor. This product is intended for research and analytical applications. Dimethachlor, a synthetic herbicide, inhibits the undesirable growth of weeds via the suppression of very long-chain fatty acid synthesis. Dimethachlor disrupts normal developmental processes via the induction of apoptosis and ROS production .

HY-N7392

Acetoacetyl-CoA	Biochemical Assay Reagents	Metabolic Disease
Acetoacetyl CoA is the precursor of HMG-CoA in the mevalonate pathway. Acetoacetyl-CoA thiolase catalyzes the reaction to form acetoacetyl-CoA from two acetyl-CoA molecules. Acetoacetyl CoA is essential for cholesterol biosynthesis. Acetoacetyl-CoA is also a intermediate in the biological breakdown and synthesis of fatty acids .

HY-160679

BaENR-IN-1	Bacterial	Infection
BaENR-IN-1 (Compound 5) is an inhibitor of Enoyl-Acyl Carrier Protein Reductase (ENR) (IC₅₀= 7.7 μM). BaENR-IN-1 blocks the synthesis of fatty acids essential for bacterial growth by inhibiting the bacterial enzyme ENR. BaENR-IN-1 shows activity against bacteria .

HY-120777

GSK729	Others	Others
GSK729 is a THPP inhibitor with the activity of inhibiting EchA6 and inhibiting Mycobacterium tuberculosis. GSK729 can selectively pull down EchA6 in a stereospecific manner, inhibit its activity, inhibit fatty acid synthesis of Mycobacterium tuberculosis, and has a bactericidal effect in a mouse chronic tuberculosis infection model.

HY-N7347

(-)-Hydroxycitric acid lactone Garcinia lactone	ATP Citrate Lyase	Metabolic Disease
(-)-Hydroxycitric acid lactone (Garcinia lactone) is an anti-obesity agent and a popular weight loss food supplement. (-)-Hydroxycitric acid lactone is a potent inhibitor of ATP-citrate lyase. (-)-Hydroxycitric acid lactone catalyzes the extramitochondrial cleavage of citrate to oxaloacetate and acetyl-CoA, limits the availability of acetyl-CoA units required for fatty acid synthesis .

HY-P2989

Pyruvate carboxylase	Endogenous Metabolite	Metabolic Disease
Pyruvate carboxylase is a biotin-containing enzyme that catalyzes the HCO3 ⁻ and MgATP dependent carboxylation of pyruvate to form oxaloacetate. Pyruvate carboxylase plays an essential role in controlling whole-body energetics through regulation of gluconeogenesis in the liver, synthesis of fatty acids in adipocytes, and insulin secretion in pancreatic β cells .

HY-N2086S

Ethyl palmitate-d31 Ethyl hexadecanoate-d₃₁	Isotope-Labeled Compounds	Others
Ethyl palmitate-d₃₁ is the deuterium labeled Ethyl palmitate. Ethyl palmitate, a fatty acid ethyl ester (FAEE), shows a marked preference for the synthesis of ethyl palmitate and ethyl oleate over other FAEEs in human subjects after ethanol consumption. Ethyl palmitate is used as a hair- and skin-conditioning agent[1].

HY-W093183

Palmitic anhydride Palmitic acid anhydride	Biochemical Assay Reagents	Others
Palmitic anhydride, a saturated fatty acid found in many natural sources such as animal fats and vegetable oils, is commonly used as a reagent in organic synthesis to introduce palmitoyl(hexadecanoyl) functional groups into other organic molecules, moreover, Palmitic anhydride has been Used in the production of surfactants, lubricants and plasticizers, as well as in the preparation of cosmetics and pharmaceuticals.

HY-N2086R

Ethyl palmitate (Standard)	Others	Others
Ethyl palmitate (Standard) is the analytical standard of Ethyl palmitate. This product is intended for research and analytical applications. Ethyl palmitate, a fatty acid ethyl ester (FAEE), shows a marked preference for the synthesis of ethyl palmitate and ethyl oleate over other FAEEs in human subjects after ethanol consumption. Ethyl palmitate is used as a hair- and skin-conditioning agent .

HY-F0003

NADPH tetrasodium salt Maximum Cited Publications 10 Publications Verification	Ferroptosis Endogenous Metabolite	Cancer
NADPH tetrasodium salt functions as an important cofactor in a variety of metabolic and biosynthetic pathways. NADPH tetrasodium salt plays a vital role in the biosynthesis of agents, chiral alcohols, fatty acids and biopolymers, while also being required for lipid biosynthesis, biomass formation, and cell replication. The demand for NADPH tetrasodium salt is particularly high in proliferating cancer cells, where it acts as a cofactor for the synthesis of nucleotides, proteins, and fatty acids. NADPH tetrasodium salt is also essential for the neutralization of the dangerously high levels of reactive oxygen species (ROS) generated by increased metabolic activity. NADPH tetrasodium salt is an endogenous inhibitor of ferroptosis .

Cat. No.	Product Name

HY-L182

Fatty Acids Compound Library

296 compounds

Fatty acids (FAs) are the main components of lipids. The synthesis of fatty acids mainly involves the Triglyceride (TG) cycle and De Novo Lipogenesis (DNL). Fatty acids which exist widely in organisms are components of cell membranes and play an indispensable role in cell signaling. In addition, FFAs can be taken up from circulating plasma by all mitochondria-containing cells, and they are metabolized by β-oxidation and the citric acid cycle to release large amounts of energy in the form of ATP. Abnormal fatty acid metabolism is associated with the occurrence and development of cardiovascular diseases, diabetes, fatty liver, hyperthyroidism, and other diseases.

MCE offers a unique collection of fatty acid compounds. Fatty Acids Compound Library is an important tool for the study of energy metabolism and drug development of metabolism-related diseases.

HY-L064

Glutamine Metabolism Compound Library

955 compounds

Glutamine is an important metabolic fuel that helps rapidly proliferating cells meet the increased demand for ATP, biosynthetic precursors, and reducing agents. Glutamine Metabolism pathway involves the initial deamination of glutamine by glutaminase(GLS), yielding glutamate and ammonia. Glutamate is converted to the TCA cycle intermediate α-ketoglutarate (α-KG) by either glutamate dehydrogenase (GDH) or by the alanine or aspartate transaminases (TAs), to produce both ATP and anabolic carbons for the synthesis of amino acids, nucleotides and lipids. During periods of hypoxia or mitochondrial dysfunction, α-KG can be converted to citrate in a reductive carboxylation reaction catalyzed by IDH2. The newly formed citrate exits the mitochondria where it is used to synthesize fatty acids and amino acids and produce the reducing agent, NADPH.

Cancer cells display an altered metabolic circuitry that is directly regulated by oncogenic mutations and loss of tumor suppressors. Mounting evidence indicates that altered glutamine metabolism in cancer cells has critical roles in supporting macromolecule biosynthesis, regulating signaling pathways, and maintaining redox homeostasis, all of which contribute to cancer cell proliferation and survival. Thus, intervention in glutamine metabolic processes could provide novel approaches to improve cancer treatment.

MCE owns a unique collection of 955 compounds targeting the mainly proteins and enzymes involved in glutamine metabolism pathway. Glutamine Metabolism compound library is a useful tool for intervention in glutamine metabolic processes.

Cat. No.	Product Name	Type

HY-D1610

BODIPY FL C5	Dyes
BODIPY FL C₅ is a *green fluorescent fatty* acid*. BODIPY FL C₅ can be used as a precursor for the synthesis* of various fluorescent phospholipids. BODIPY FL C₅ is relatively insensitive to the environment and fluoresces in both water-soluble and lipid environments .

Cat. No.	Product Name	Type

HY-W093183

Palmitic anhydride

Palmitic acid anhydride

Biochemical Assay Reagents

Palmitic anhydride, a saturated fatty acid found in many natural sources such as animal fats and vegetable oils, is commonly used as a reagent in organic synthesis to introduce palmitoyl(hexadecanoyl) functional groups into other organic molecules, moreover, Palmitic anhydride has been Used in the production of surfactants, lubricants and plasticizers, as well as in the preparation of cosmetics and pharmaceuticals.

HY-126912A

Lauroyl coenzyme A lithium	Drug Delivery
Lauroyl coenzyme A lithium salt is an intermediary in fatty acid synthesis or metabolism, formed by combining long-chain fatty acids (or lauric acid) with coenzyme A. Lauroyl coenzyme A lithium salt is involved in lipid biosynthesis and fatty acid transport, in which coenzyme A acts as a transport molecule to help move and target specific compounds.

HY-W127423

Methyl 2-hydroxyoctadecanoate	Biochemical Assay Reagents
Methyl (+/-)-2-hydroxystearateis a hydroxylated fatty acid methyl ester that broadens phase transitions in dimyristoylphosphatidylcholine (DMPC) lipid membranes. It has been used in the synthesis of lipid-nucleotide conjugated anti-HIV agents to increase the cleavage of phosphodiester bonds and the number of released intracellular nucleotides.

HY-N7392

Acetoacetyl-CoA	Biochemical Assay Reagents
Acetoacetyl CoA is the precursor of HMG-CoA in the mevalonate pathway. Acetoacetyl-CoA thiolase catalyzes the reaction to form acetoacetyl-CoA from two acetyl-CoA molecules. Acetoacetyl CoA is essential for cholesterol biosynthesis. Acetoacetyl-CoA is also a intermediate in the biological breakdown and synthesis of fatty acids .

HY-W127524

8-Methylnonanoic acid

Drug Delivery

8-Methylnonanoic acidIt is an organic compound belonging to fatty acids. It has a faint waxy smell and is commonly found in a variety of foods, such as cheese and butter. 8-Methylnonanoic acidIt has various applications in the chemical and pharmaceutical industries, especially as an intermediate in the synthesis of various chemicals and pharmaceuticals. In addition, it can also be used as a flavoring agent in food.

HY-W127507

cis-11-Hexadecenal

Biochemical Assay Reagents

cis-11-Hexadecenal has a fatty, waxy odor and is commonly used as a flavoring agent in the food and beverage industry. In addition, it can be used as an intermediate in the synthesis of various organic compounds, including fragrances, pharmaceuticals, and agrochemicals. Its unique chemical properties make it an important ingredient in a variety of industrial processes, notably in the production of perfumes and air fresheners.

HY-W105734

15-Hydroxypentadecanoic acid

Drug Delivery

15-Hydroxypentadecanoic acid is a long-chain fatty acid found in various plant and animal sources and also produced by bacteria and fungi. It has potential health benefits and is used as an intermediate in the synthesis of other organic compounds, including pharmaceuticals, agrochemicals and surfactants. Its unique chemical properties make it an essential ingredient in several industrial processes, especially in the fields of food science and nutrition.

HY-W127384

3-Decenoic acid

Drug Delivery

3-Decenoic acidIt is an organic compound belonging to the class of unsaturated fatty acids. It has a strong rancid smell and is commonly found in a variety of foods, such as dairy products and meat. 3-Decenoic acidIt has various applications in the pharmaceutical industry, especially as an intermediate in the synthesis of antibacterial agents such as antibiotics. In addition, it is used as a food preservative to prevent the growth of microorganisms.

HY-W127476

3-Nonenoic Acid

Drug Delivery

3-Nonenoic AcidIt is an organic compound belonging to the class of unsaturated fatty acids. It is a colorless liquid with a pungent smell and is commonly found in various foods such as cheese and butter. 3-Nonenoic AcidIt has various applications in the chemical and pharmaceutical industries, especially as an intermediate in the synthesis of various chemicals and drugs. In addition, it can also be used as a flavoring agent in food.

HY-W127562

2-Tridecenoic acid

Drug Delivery

2-Tridecenoic acid is an organic compound belonging to the class of fatty acids. It has a slightly rancid smell and is commonly found in a variety of foods, such as dairy products and meats. 2-Tridecenoic acid has various applications in the chemical and pharmaceutical industries, especially as an intermediate in the synthesis of various chemicals and pharmaceuticals. Additionally, it has potential utility in inhibiting bacterial infections and inflammation-related diseases.

HY-W009544

3-Hydroxytetradecanoic acid

3-Hydroxymyristic acid

Biochemical Assay Reagents

3-Hydroxytetradecanoic acidis a saturated fatty acid. 3-Hydroxytetradecanoic acidOccurs naturally in various animal and plant sources such as butter and milk fat. 3-Hydroxytetradecanoic acidIt has various uses in industry, especially in the production of soaps, detergents and other surfactants. 3-Hydroxytetradecanoic acidIt is also used as a precursor for the synthesis of other bioactive compounds such as antibiotics and anticancer drugs.

HY-W015305

Ethyl octanoate

Octanoic acid ethyl ester

Drug Delivery

Ethyl octanoate is a class of esters consisting of the medium-chain fatty acid octanoic acid esterified with ethanol. The compound has a fruity smell and is commonly used as a flavoring in foods such as baked goods, candy and beverages. It can also be used as a fragrance ingredient in personal care products, and as a solvent or plasticizer in various industrial applications. In addition, Ethyl octanoate can be used as a starting material for the synthesis of other organic compounds.

HY-W013203

Ethyl icosanoate

Icosanoic acid Ethyl Ester

Drug Delivery

Ethyl icosanoate is an ester, which is formed by the esterification of long-chain straight-chain fatty acids, eicosanoic acid and ethanol. The compound has a fruity, waxy smell and is commonly used as a flavoring in foods such as baked goods, candy and beverages. It is also used as a fragrance ingredient in personal care products and as a lubricant or plasticizer in various industrial applications. In addition, Ethyl icosanoate can be used as a starting material for the synthesis of other organic compounds.

HY-W014207

Ethyl undecanoate

Drug Delivery

Ethyl undecanoate is a class of esters consisting of long-chain straight-chain fatty acids, undecanoic acid, esterified with ethanol. The compound has a fruity smell and is commonly used as a flavoring in foods such as baked goods, candy and beverages. It is also used as a fragrance ingredient in personal care products and as a lubricant or plasticizer in various industrial applications. In addition, Ethyl undecanoate can be used as a starting material for the synthesis of other organic compounds.

HY-W107869

2-Heptenoic acid

Biochemical Assay Reagents

2-Heptenoic acid is an unsaturated fatty acid. It is a clear, colorless liquid with a strong odour, and is commonly used in the flavor and fragrance industry for its pungent, anise-like odor. In addition, it can be used as an intermediate in the synthesis of other organic compounds, including pharmaceuticals and agrochemicals. Its unique chemical properties make it an important ingredient in a variety of industrial applications, including food and beverage production, cosmetics and personal care products.

HY-N7833

Heneicosapentaenoic acid

Drug Delivery

Heneicosapentaenoic Acid (HPA) is a 21:5 omega-3 fatty acid found in trace amounts in the green alga B. pennata and in fish oils. Its chemical composition is similar to eicosapentaenoic acid (EPA), except that a carbon is extended at the carboxy terminus, placing the first double bond at the δ6 position. HPA can be used to study the importance of double bond position in omega-3 fatty acids. It incorporates phospholipids and triacylglycerols in vivo with the same efficiency as EPA and docosahexaenoic acid, and exhibits a strong inhibitory effect on the synthesis of arachidonic acid from linoleic acid. HPA is a poor substrate for prostaglandin H synthase (PGHS) (cyclooxygenase) and 5-lipoxygenase, but retains the ability to rapidly inactivate PGHS.

HY-W127443

3-Heptenoic acid

Drug Delivery

3-Heptenoic acidIt is an organic compound belonging to the class of unsaturated fatty acids. It has a strong, unpleasant smell and is commonly found in a variety of foods, such as beer and dairy products. 3-Heptenoic acidIt has various applications in the fragrance and fragrance industry, especially as a fragrance and flavoring agent in products such as perfume, cologne and food additives. In addition, it can also be used as an intermediate in the synthesis of various chemicals and drugs.

HY-W105359

9-Decen-1-ol

ω-Decen-1-ol

Biochemical Assay Reagents

9-Decen-1-ol has a fatty odour. This compound is used in the flavor and fragrance industry for its pleasant smell, which is often described as sweet, floral and fruity. It can also be used as an intermediate in the synthesis of various organic compounds, including medicine, agricultural chemicals and polymer materials. Its unique chemical properties make it an important ingredient in many commercial products, including soaps, detergents and cosmetics.

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N2078

Yamogenin Neodiosgenin	Structural Classification other families Classification of Application Fields Source classification Metabolic Disease Plants Disease Research Fields Steroids	LXR
Yamogenin (Neodiosgenin) is a diastereomer of diosgenin. Yamogenin (Neodiosgenin) antagonizes the activation of the liver X receptor (LXR) in luciferase ligand assay. Yamogenin (Neodiosgenin) inhibits triacylglyceride (TG) accumulation through the suppression of gene expression of fatty acid synthesis in HepG2 hepatocytes .

HY-W010382

Oxaloacetic acid 2-Oxosuccinic acid	Structural Classification Human Gut Microbiota Metabolites Microorganisms Other disease Classification of Application Fields Anti-aging Ketones, Aldehydes, Acids Source classification Disease markers Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite Reactive Oxygen Species
Oxaloacetic acid (2-Oxosuccinic acid) is a metabolic intermediate involved in several ways, such as citric acid cycle, gluconeogenesis, the urea cycle, the glyoxylate cycle, amino acid synthesis, and fatty acid synthesis, whereby Oxaloacetic acid facilitates the clearance of reactive oxygen species (ROS) and improves mitochondrial function .

HY-113427

trans-Vaccenic acid	Structural Classification Animals Classification of Application Fields Ketones, Aldehydes, Acids Source classification Other Diseases Endogenous metabolite Disease Research Fields	Endogenous Metabolite
trans-Vaccenic acid is a precursor for the synthesis of saturated fatty acid in the rumen and of conjugated linoleic acid (CLA) at the tissue level.

HY-B0511

Biotin Maximum Cited Publications 10 Publications Verification Vitamin B7; Vitamin H; D-Biotin	Structural Classification Immune System Disorder Microorganisms other families Classification of Application Fields Ketones, Aldehydes, Acids Source classification Disease markers Metabolic Disease Plants Endogenous metabolite Disease Research Fields	Endogenous Metabolite
Biotin, vitamin B7 and serves as a coenzyme for five carboxylases in humans, involved in the synthesis of fatty acids, isoleucine, and valine, and in gluconeogenesis. Biotin is necessary for cell growth, the production of fatty acids, and the metabolism of fats and amino acids .

HY-110028

Leelamine hydrochloride	Structural Classification other families Classification of Application Fields Pinaceae Terpenoids Source classification Diterpenoids Plants Disease Research Fields Pinus massoniana Lamb. Endocrinology	Cannabinoid Receptor Fatty Acid Synthase (FASN) Androgen Receptor
Leelamine hydrochloride is a tricyclic diterpene molecule that is extracted from the bark of pine trees . Leelamine hydrochloride is a cannabinoid receptor type 1 (CB1) agonist and a inhibitor of SREBP1-regulated **fatty acid/lipid synthesis in prostate cancer cells that is not affected by androgen receptor status. Leelamine hydrochloride suppresses transcriptional activity of androgen receptor*, which is known to regulate fatty* acid synthesis ^[2,3].

HY-B0511R

Biotin (Standard) Vitamin B7 (Standard); Vitamin H (Standard); D-Biotin (Standard)	Structural Classification Natural Products Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite
Biotin (Standard) is the analytical standard of Biotin. Biotin, vitamin B7 and serves as a coenzyme for five carboxylases in humans, involved in the synthesis of fatty acids, isoleucine, and valine, and in gluconeogenesis. Biotin is necessary for cell growth, the production of fatty acids, and the metabolism of fats and amino acids .

HY-W018392

Mono-(2-ethylhexyl) phthalate 5+ Cited Publications MEHP; Phthalic acid mono-2-ethylhexyl ester	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite
Mono-(2-ethylhexyl) phthalate (MEHP) is a major bioactive metabolite of diethylhexyl phthalate (DEHP). Mono-(2-ethylhexyl) phthalate can promote fatty acid synthesis in hepatocytes by regulating the expression of relevant genes and proteins, contributing to non-alcoholic fatty liver disease (NAFLD) .

HY-16007

(-)-Hydroxycitric acid Garcinia acid	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Guttiferae Metabolic Disease Plants Garcinia cambogia Disease Research Fields	ATP Citrate Lyase
(-)-Hydroxycitric acid (Garcinia acid) is the principal acid of fruit rinds of Garcinia cambogia. (-)-Hydroxycitric acid is a potent and competitive and orally active inhibitor of ATP citrate lyase. (-)-Hydroxycitric acid suppresses the fatty acid synthesis, lipogenesis, food intake, and induced weight loss .

HY-N2078R

Yamogenin (Standard)	Structural Classification other families Source classification Plants Steroids	LXR
Yamogenin (Standard) is the analytical standard of Yamogenin. This product is intended for research and analytical applications. Yamogenin (Neodiosgenin) is a diastereomer of diosgenin. Yamogenin (Neodiosgenin) antagonizes the activation of the liver X receptor (LXR) in luciferase ligand assay. Yamogenin (Neodiosgenin) inhibits triacylglyceride (TG) accumulation through the suppression of gene expression of fatty acid synthesis in HepG2 hepatocytes .

HY-B0511A

Biotin sodium Vitamin B7 sodium; Vitamin H sodium; D-Biotin sodium	Structural Classification Natural Products Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite
Biotin (Vitamin B7) sodium is a water-soluble B vitamin and serves as a coenzyme for five carboxylases in humans, involved in the synthesis of fatty acids, isoleucine, and valine, and in gluconeogenesis. Biotin sodium is necessary for cell growth, the production of fatty acids, and the metabolism of fats and amino acids .

HY-W018392R

Mono-(2-ethylhexyl) phthalate (Standard)	Structural Classification Ketones, Aldehydes, Acids Source classification Endogenous metabolite	Endogenous Metabolite
Mono-(2-ethylhexyl) phthalate (Standard) is the analytical standard of Mono-(2-ethylhexyl) phthalate. This product is intended for research and analytical applications. Mono-(2-ethylhexyl) phthalate (MEHP) is a major bioactive metabolite of diethylhexyl phthalate (DEHP). Mono-(2-ethylhexyl) phthalate can promote fatty acid synthesis in hepatocytes by regulating the expression of relevant genes and proteins, contributing to non-alcoholic fatty liver disease (NAFLD) .

HY-N2486

Desoxyrhaponticin 1 Publications Verification	Structural Classification Monophenols Stilbenes Classification of Application Fields Polygonaceae Source classification Rheum rhabarbarum Linnaeus Phenols Plants Rheum tanguticum Disease Research Fields Cancer	Fatty Acid Synthase (FASN) Apoptosis
Desoxyrhaponticin is a kind of oral drug that inhibits effective fatty acid synthesis (FASN), and has a fatal effect on cancer cells. Desoxyrhaponticin has the ability to inhibit glucose uptake, improve oral glucose tolerance as a diabetic agent, and possess anti-diabetic effects .

HY-N7392

Acetoacetyl-CoA	Human Gut Microbiota Metabolites Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Biochemical Assay Reagents
Acetoacetyl CoA is the precursor of HMG-CoA in the mevalonate pathway. Acetoacetyl-CoA thiolase catalyzes the reaction to form acetoacetyl-CoA from two acetyl-CoA molecules. Acetoacetyl CoA is essential for cholesterol biosynthesis. Acetoacetyl-CoA is also a intermediate in the biological breakdown and synthesis of fatty acids .

HY-N7347

(-)-Hydroxycitric acid lactone Garcinia lactone	Structural Classification other families Classification of Application Fields Ketones, Aldehydes, Acids Source classification Metabolic Disease Plants Disease Research Fields	ATP Citrate Lyase
(-)-Hydroxycitric acid lactone (Garcinia lactone) is an anti-obesity agent and a popular weight loss food supplement. (-)-Hydroxycitric acid lactone is a potent inhibitor of ATP-citrate lyase. (-)-Hydroxycitric acid lactone catalyzes the extramitochondrial cleavage of citrate to oxaloacetate and acetyl-CoA, limits the availability of acetyl-CoA units required for fatty acid synthesis .

HY-N2086R

Ethyl palmitate (Standard)	Structural Classification Natural Products Microorganisms Source classification Dicerothamnus rhinocerotis Umbelliferae Plants	Others
Ethyl palmitate (Standard) is the analytical standard of Ethyl palmitate. This product is intended for research and analytical applications. Ethyl palmitate, a fatty acid ethyl ester (FAEE), shows a marked preference for the synthesis of ethyl palmitate and ethyl oleate over other FAEEs in human subjects after ethanol consumption. Ethyl palmitate is used as a hair- and skin-conditioning agent .

HY-N2486R

Desoxyrhaponticin (Standard)	Structural Classification Monophenols Stilbenes Polygonaceae Source classification Rheum rhabarbarum Linnaeus Phenols Plants Rheum tanguticum	Fatty Acid Synthase (FASN) Apoptosis
Desoxyrhaponticin (Standard) is the analytical standard of Desoxyrhaponticin. This product is intended for research and analytical applications. Desoxyrhaponticin is a kind of oral drug that inhibits effective fatty acid synthesis (FASN), and has a fatal effect on cancer cells. Desoxyrhaponticin has the ability to inhibit glucose uptake, improve oral glucose tolerance as a diabetic agent, and possess anti-diabetic effects .

HY-N7347R

(-)-Hydroxycitric acid lactone (Standard)	Structural Classification other families Ketones, Aldehydes, Acids Source classification Plants	ATP Citrate Lyase
(-)-Hydroxycitric acid lactone (Standard) is the analytical standard of (-)-Hydroxycitric acid lactone. This product is intended for research and analytical applications. (-)-Hydroxycitric acid lactone (Garcinia lactone) is an anti-obesity agent and a popular weight loss food supplement. (-)-Hydroxycitric acid lactone is a potent inhibitor of ATP-citrate lyase. (-)-Hydroxycitric acid lactone catalyzes the extramitochondrial cleavage of citrate to oxaloacetate and acetyl-CoA, limits the availability of acetyl-CoA units required for fatty acid synthesis .

Cat. No.	Product Name	Chemical Structure

HY-W010382S

Oxaloacetic acid-13C4
Oxaloacetic acid- ¹³C₄ is the ¹³C-labeled Oxaloacetic acid. Oxaloacetic acid (2-Oxosuccinic acid) is a metabolic intermediate involved in several ways, such as citric acid cycle, gluconeogenesis, the urea cycle, the glyoxylate cycle, amino acid synthesis, and fatty acid synthesis[1][2][3].

HY-N2086S

Ethyl palmitate-d31
Ethyl palmitate-d₃₁ is the deuterium labeled Ethyl palmitate. Ethyl palmitate, a fatty acid ethyl ester (FAEE), shows a marked preference for the synthesis of ethyl palmitate and ethyl oleate over other FAEEs in human subjects after ethanol consumption. Ethyl palmitate is used as a hair- and skin-conditioning agent[1].

HY-W018392S

Mono-(2-ethylhexyl) phthalate-d4

Mono-(2-ethylhexyl) phthalate-d₄ is a deuterium labeled Mono-(2-ethylhexyl) phthalate (HY-W018392). Mono-(2-ethylhexyl) phthalate (MEHP) is a major bioactive metabolite of diethylhexyl phthalate (DEHP). Mono-(2-ethylhexyl) phthalate can promote fatty acid synthesis in hepatocytes by regulating the expression of relevant genes and proteins, contributing to non-alcoholic fatty liver disease (NAFLD) .

Cat. No.	Product Name		Classification

HY-F0003

NADPH tetrasodium salt 5+ Cited Publications		Nucleotides and their Analogs
NADPH tetrasodium salt functions as an important cofactor in a variety of metabolic and biosynthetic pathways. NADPH tetrasodium salt plays a vital role in the biosynthesis of agents, chiral alcohols, fatty acids and biopolymers, while also being required for lipid biosynthesis, biomass formation, and cell replication. The demand for NADPH tetrasodium salt is particularly high in proliferating cancer cells, where it acts as a cofactor for the synthesis of nucleotides, proteins, and fatty acids. NADPH tetrasodium salt is also essential for the neutralization of the dangerously high levels of reactive oxygen species (ROS) generated by increased metabolic activity. NADPH tetrasodium salt is an endogenous inhibitor of ferroptosis .

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fatty acid synthesis

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