2. Immunology/Inflammation MAPK/ERK Pathway
  3. AP-1 JNK
  4. 15(S)-HPETE

15(S)-HPETE is a monohydroperoxy polyunsaturated fatty acid (PUFA) produced by the action of 15-lipoxygenase (15-LO) on arachidonic acid. It is either metabolized to 14,15-leukotriene A41 or reduced to 15(S)-HETE by peroxidases.2,1 15(S)-HpETE mediates a number of biological functions including the induction of c-fos and c-jun, and activation of AP-1.3 15(S)-HpETE inhibits prostacyclin synthesis in porcine aortic microsomes and bovine endothelial cells, and can cause the suicide inactivation of porcine 12-LO.

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15(S)-HPETE Chemical Structure

15(S)-HPETE Chemical Structure

CAS No. : 70981-96-3

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15(S)-HPETE Related Antibodies

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c-Fos c-Jun

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Description

15(S)-HPETE is a monohydroperoxy polyunsaturated fatty acid (PUFA) produced by the action of 15-lipoxygenase (15-LO) on arachidonic acid. It is either metabolized to 14,15-leukotriene A41 or reduced to 15(S)-HETE by peroxidases.2,1 15(S)-HpETE mediates a number of biological functions including the induction of c-fos and c-jun, and activation of AP-1.3 15(S)-HpETE inhibits prostacyclin synthesis in porcine aortic microsomes and bovine endothelial cells, and can cause the suicide inactivation of porcine 12-LO.

IC50 & Target

c-Fos

 

c-Jun

 

Molecular Weight

336.47

Formula

C20H32O4
CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

CCCCC[C@H](OO)/C=C/C=C\C/C=C\C/C=C\CCCC(O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Solution, -20°C, 2 years
Purity & Documentation

Purity: ≥97.0%

COA (239 KB)

Handling Instructions (2659 KB)
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15(S)-HPETE Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

15(S)-HPETE70981-96-3AP-1JNKActivator Protein 1c-Jun N-terminal kinaseInhibitorinhibitorinhibit

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