2. Anti-infection Apoptosis
  3. Bacterial Fungal Antibiotic Apoptosis
  4. Triclosan

Triclosan is a broad-spectrum antibacterial agent that inhibits bacterial fatty acid synthesis at the enoyl-acyl carrier protein reductase (FabI) step. Triclosan inhibits E. coli enoyl-acyl carrier protein reductase (FabI) and FabI containing a glycine-to-valine substitution at position 93 (FabIG93V) with IC50s of 2 µM and 10 µM, respectively. Triclosan causes apoptotic effect in cultured rat neural stem cells (NSC). Triclosan exacerbates colitis and colitis-associated colorectal tumorigenesis in animal models.

For research use only. We do not sell to patients.

Triclosan Chemical Structure

Triclosan Chemical Structure

CAS No. : 3380-34-5

Size Price Stock Quantity
Free Sample (0.1 - 0.5 mg)   Apply Now  
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 51 In-stock
Solution
10 mM * 1 mL in DMSO USD 51 In-stock
Solid
100 mg USD 47 In-stock
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 6 publication(s) in Google Scholar

Other Forms of Triclosan:

Triclosan Related Antibodies

Top Publications Citing Use of Products

View All Antibiotic Isoform Specific Products:

View All Isoforms
Aminoglycoside Glycopeptide Lipopeptide Macrolide Oxazolidinone Quinolone Tetracycline β-lactam

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Triclosan is a broad-spectrum antibacterial agent that inhibits bacterial fatty acid synthesis at the enoyl-acyl carrier protein reductase (FabI) step. Triclosan inhibits E. coli enoyl-acyl carrier protein reductase (FabI) and FabI containing a glycine-to-valine substitution at position 93 (FabIG93V) with IC50s of 2 µM and 10 µM, respectively. Triclosan causes apoptotic effect in cultured rat neural stem cells (NSC). Triclosan exacerbates colitis and colitis-associated colorectal tumorigenesis in animal models[1][2][3].

Cellular Effect
Cell Line Type Value Description References
B-cell IC50
20 μM
Compound: Triclosan
Antiproliferative activity against Theileria parva-induced proliferation of bovine B lymphocyte assessed as inhibition of [3H]thymidine uptake after 48 hrs
Antiproliferative activity against Theileria parva-induced proliferation of bovine B lymphocyte assessed as inhibition of [3H]thymidine uptake after 48 hrs
[PMID: 19075064]
In Vitro

Triclosan (1-100 μM ; 24 h) decreases in cell viability in dose and time dependent manners with 50 and 100 μM. Triclosan with 50 μM significantly increases cleaved caspase3 and Bax proteins and decreases Bcl-2[2].
Triclosan (50 μM ; 1-3 h) induces the increased expressions of both phosphorylated p38 and JNK proteins[2].
Triclosan (10-50 μM ; 3 h) with 50 μM decreases the GSH activity and increases the ROS generation to about 40% in cultured NSCs[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Triclosan Related Antibodies

Cell Viability Assay[2]

Cell Line: Neural stem wells
Concentration: 1, 10, 20, 30, 50 and 100 μM
Incubation Time: 24 h
Result: Initiated the decreases in cell viability in dose and time dependent manners with 50 and 100 μM.

Western Blot Analysis[2]

Cell Line: Neural stem wells
Concentration: 50 μM
Incubation Time: 1, 3 h
Result: Did not affect the expressions of MAPK signaling proteins per se.
Differentially induced the increased expressions of both phosphorylated p38 and JNK proteins.
In Vivo

Triclosan (5, 50, 500 mg/kg; oral gavage, five days a week for a total of four weeks) causes an increase in the production of anti‐Der f IgE, IL‐4, and IL‐13[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Wild type BALB/cJ mice[3]
Dosage: 5, 50, 500 mg/kg
Administration: Oral gavage, five days a week for a total of four weeks
Result: Caused an increase in the production of anti- dermatophagoides farinae (Der f) IgE, IL‐4, and IL‐13, and this resulted in the aggravation of airway hyperresponsiveness in aeroallergen‐exposed wild type mice.
Clinical Trial
Molecular Weight

289.54

Formula

C12H7Cl3O2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

OC1=CC(Cl)=CC=C1OC2=CC=C(Cl)C=C2Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (345.38 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Methanol : 100 mg/mL (345.38 mM; Need ultrasonic)

H2O : < 0.1 mg/mL (insoluble)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.4538 mL 17.2688 mL 34.5375 mL
5 mM 0.6908 mL 3.4538 mL 6.9075 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 2.5 mg/mL (8.63 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

    Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
  • Protocol 2

    Add each solvent one by one:  10% DMSO    90% Corn Oil

    Solubility: ≥ 2.5 mg/mL (8.63 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO +
% 
+
%
Tween-80 +
%
Saline
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration: mg/mL
Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
 If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation

Purity: 99.96%

SDS (597 KB)

COA (248 KB) HNMR (111 KB) RP-HPLC (189 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO / Methanol 1 mM 3.4538 mL 17.2688 mL 34.5375 mL 86.3439 mL
5 mM 0.6908 mL 3.4538 mL 6.9075 mL 17.2688 mL
10 mM 0.3454 mL 1.7269 mL 3.4538 mL 8.6344 mL
15 mM 0.2303 mL 1.1513 mL 2.3025 mL 5.7563 mL
20 mM 0.1727 mL 0.8634 mL 1.7269 mL 4.3172 mL
25 mM 0.1382 mL 0.6908 mL 1.3815 mL 3.4538 mL
30 mM 0.1151 mL 0.5756 mL 1.1513 mL 2.8781 mL
40 mM 0.0863 mL 0.4317 mL 0.8634 mL 2.1586 mL
50 mM 0.0691 mL 0.3454 mL 0.6908 mL 1.7269 mL
60 mM 0.0576 mL 0.2878 mL 0.5756 mL 1.4391 mL
80 mM 0.0432 mL 0.2159 mL 0.4317 mL 1.0793 mL
100 mM 0.0345 mL 0.1727 mL 0.3454 mL 0.8634 mL
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

Triclosan Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Triclosan3380-34-5BacterialFungalAntibioticApoptosisAntibacterialfatty acid synthesisenoyl-acyl carrier protein reductaseFabIFabIG93Vneural stem cellscolitiscolorectal tumorigenesisInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Salutation

Applicant Name *

 

Email Address *

Phone Number *

 

Organization Name *

Department *

 

Requested quantity *

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
Triclosan
Cat. No.:
HY-B1119
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

SAFETY DATA SHEET (SDS)

English - EN (597 KB) Français - FR (597 KB) Deutsch - DE (597 KB) Norwegian - NO (597 KB) Español - ES (597 KB) Swedish - SV (597 KB)

Request for HNMR Report

We have received your request and will respond to you as soon as possible.