glutamate dehydrogenase

By Targets:	Glutamate Dehydrogenase (GLDH) (1) Apoptosis (4) Autophagy (1) Biochemical Assay Reagents (3) Endogenous Metabolite (9) Ferroptosis (1) HIV (1) Isotope-Labeled Compounds (1) Mitochondrial Metabolism (2) Oxidative Phosphorylation (1) Reactive Oxygen Species (3)
By Research Areas:	Cancer (8) Endocrinology (1) Inflammation/Immunology (4) Metabolic Disease (5) Neurological Disease (2)

Targets Recommended: Glutamate Dehydrogenase (GLDH) Succinate Dehydrogenase Lactate Dehydrogenase Dihydroorotate Dehydrogenase Isocitrate Dehydrogenase (IDH) Methylenetetrahydrofolate Dehydrogenase (MTHFD) Phosphoglycerate Dehydrogenase (PHGDH) Aldehyde Dehydrogenase (ALDH) mGluR iGluR EAAT PDHK 15-PGDH 17β-HSD 11β-HSD

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-E70003

**Glutamate dehydrogenase**	Biochemical Assay Reagents	Endocrinology
Glutamate dehydrogenase is an enzyme in both prokaryotes and eukaryotic mitochondria. Glutamate dehydrogenase can be used for the enzymatic determination of ammonia, alpha-ketoglutaric acid, L-glutamate and urease .

HY-P2911

Glutamate dehydrogenase (NAD(P)) GLDH	Mitochondrial Metabolism	Others
Glutamate dehydrogenase NAD(P) (GLDH) can be found in hepatocytes, renal tissue, brain, muscle, and intestinal cells. Glutamate dehydrogenase NAD(P) is often used in biochemical studies. Glutamate dehydrogenase is a mitochondrial enzyme, it catalyzes the reversible oxidative deamination of glutamate to α-ketoglutarate (α-KG) as part of the urea cycle .

HY-134136A

Octanoyl coenzyme A lithium	Biochemical Assay Reagents	Cancer
Octanoyl coenzyme A lithium is a fatty acyl coenzyme A derivative. Octanoyl coenzyme A lithium can inhibit citrate synthase (CS) and **glutamate dehydrogenase (GDH) with IC₅₀** values of 0.4-1.6 mM .

HY-103096

R162 5+ Cited Publications	Glutamate Dehydrogenase (GLDH)	Cancer
R162 is a potent inhibitor of glutamate dehydrogenase 1 (GDH1/GLUD1), with anti-cancer properties.

HY-12688A

Succinyl phosphonate trisodium salt 10+ Cited Publications	Endogenous Metabolite Reactive Oxygen Species	Neurological Disease Metabolic Disease Cancer
Succinyl phosphonate trisodium salt is an α-ketoglutarate dehydrogenase (KGDHC) inhibitor, effective inhibits (KGDHC) in muscle, bacterial, brain, and cultured human fibroblasts . Succinyl phosphonate trisodium salt is an 2-oxoglutarate dehydrogenase (OGDH) inhibitor, impairs viability of cancer cells in a cell-specific metabolism-dependent manner . Succinyl phosphonate trisodium salt inhibits the glutamate-induced ROS production in glutamate-stimulated hippocampal neurons in situ .

HY-P2912

Glutamate dehydrogenase (NADP)	Others	Others
Glutamate dehydrogenase (NADP) is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-134136

Octanoyl Coenzyme A	Endogenous Metabolite	Metabolic Disease
Octanoyl coenzyme A is a fatty acyl coenzyme A derivative. Octanoyl coenzyme A can inhibit citrate synthase (CS) and glutamate dehydrogenase (GDH) with IC₅₀ values of 0.4-1.6 mM .

HY-134136B

Octanoyl coenzyme A triammonium	Biochemical Assay Reagents	Metabolic Disease
Octanoyl coenzyme A triammonium is a medium-chain acyl coenzyme A. Octanoyl coenzyme A triammonium can inhibit citrate synthase (CS) and **glutamate dehydrogenase (GDH) with IC₅₀** values of 0.4-1.6 mM .

HY-12688

Succinyl phosphonate	Endogenous Metabolite Reactive Oxygen Species	Neurological Disease
Succinyl phosphonate is an α-ketoglutarate dehydrogenase (KGDHC) inhibitor, effective inhibits (KGDHC) in muscle, bacterial, brain, and cultured human fibroblasts . Succinyl phosphonate trisodium salt is an 2-oxoglutarate dehydrogenase (OGDH) inhibitor, impairs viability of cancer cells in a cell-specific metabolism-dependent manner . Succinyl phosphonate trisodium salt inhibits the glutamate-induced ROS production in glutamate-stimulated hippocampal neurons in situ .

HY-W040307

Saccharopine L-Saccharopine	Endogenous Metabolite	Metabolic Disease
Saccharopine (L-Saccharopine), a lysine degradation intermediate, is a mitochondrial toxin. Lysine and α-ketoglutarate are converted into Saccharopine by the lysine-ketoglutarate reductase. Saccharopine is then oxidized to α-aminoapidate semialdehyde and glutamate by the saccharopine dehydrogenase. Saccharopine impairs development by disrupting mitochondrial homeostasis .

HY-W040307B

Saccharopine hydrochloride L-Saccharopine hydrochloride	Endogenous Metabolite	Metabolic Disease
Saccharopine (L-Saccharopine) hydrochloride, a lysine degradation intermediate, is a mitochondrial toxin. Lysine and α-ketoglutarate are converted into Saccharopine hydrochloride by the lysine-ketoglutarate reductase. Saccharopine hydrochloride is then oxidized to α-aminoapidate semialdehyde and glutamate by the saccharopine dehydrogenase. Saccharopine hydrochloride impairs development by disrupting mitochondrial homeostasis .

HY-13653

(-)-Epigallocatechin Gallate Maximum Cited Publications 34 Publications Verification EGCG; Epigallocatechol Gallate	Endogenous Metabolite Apoptosis	Inflammation/Immunology Cancer
(-)-Epigallocatechin Gallate (EGCG) is a major polyphenol in green tea, which can inhibit cell proliferation and induce cell apoptosis. (-)-Epigallocatechin Gallate inhibits glutamate dehydrogenase 1/2 (GDH1/2, GLUD1/2) activity. (-)-Epigallocatechin Gallate has a potent anticancer, antioxidant and anti-inflammatory properties against various types of cancers such as colorectal cancer, myeloid leukemia, thyroid carcinoma .

HY-13653S

(+/-)-Epigallocatechin Gallate-13C3	Oxidative Phosphorylation Autophagy Reactive Oxygen Species HIV Ferroptosis Mitochondrial Metabolism Endogenous Metabolite	Cancer
(+/-)-Epigallocatechin Gallate- ¹³C₃ is the ¹³C-labeled (-)-Epigallocatechin Gallate. (-)-Epigallocatechin Gallate is a tea flavonoid with potent antioxidant, antiinflammatory, and anticarcinogenic properties. (-)-Epigallocatechin Gallate is reported to inhibit EGFR signaling and thereby exert anticancer effects[1]. (-)-Epigallocatechin Gallate (EGCG) is a glutamate dehydrogenase 1/2 (GDH1/2, GLUD1/2) inhibitor. Epigallocatechin-3-gallate induces oxidative phosphorylation (OXPHOS) by activating cytochrome c oxidase.

HY-150526

EGCG-4″-sulfate	Endogenous Metabolite Apoptosis	Inflammation/Immunology Cancer
EGCG-4″-sulfate is a major polyphenol in green tea, which can inhibit cell proliferation and induce cell apoptosis. (-)-Epigallocatechin Gallate sulfate inhibits glutamate dehydrogenase 1/2 (GDH1/2, GLUD1/2) activity. EGCG-4″-sulfate has a potent anticancer, antioxidant and anti-inflammatory properties against various types of cancers such as colorectal cancer, myeloid leukemia, thyroid carcinoma .

HY-13653R

(-)-Epigallocatechin Gallate (Standard) Maximum Cited Publications 34 Publications Verification EGCG(Standard); Epigallocatechol Gallate (Standard)	Endogenous Metabolite Apoptosis	Inflammation/Immunology Cancer
(-)-Epigallocatechin Gallate (Standard) is the analytical standard of (-)-Epigallocatechin Gallate. This product is intended for research and analytical applications. (-)-Epigallocatechin Gallate (EGCG) is a major polyphenol in green tea, which can inhibit cell proliferation and induce cell apoptosis. (-)-Epigallocatechin Gallate inhibits glutamate dehydrogenase 1/2 (GDH1/2, GLUD1/2) activity. (-)-Epigallocatechin Gallate has a potent anticancer, antioxidant and anti-inflammatory properties against various types of cancers such as colorectal cancer, myeloid leukemia, thyroid carcinoma .

HY-13653S1

(-)-Epigallocatechin Gallate-d4 EGCG-d₄; Epigallocatechol Gallate-d₄	Isotope-Labeled Compounds Apoptosis	Inflammation/Immunology Cancer
(-)-Epigallocatechin Gallate-d4 (EGCG-d4) is the deuterium labeled (-)-Epigallocatechin Gallate (HY-13653). (-)-Epigallocatechin Gallate (EGCG) is a major polyphenol in green tea, which can inhibit cell proliferation and induce cell apoptosis. (-)-Epigallocatechin Gallate inhibits glutamate dehydrogenase 1/2 (GDH1/2, GLUD1/2) activity. (-)-Epigallocatechin Gallate has a potent anticancer, antioxidant and anti-inflammatory properties against various types of cancers such as colorectal cancer, myeloid leukemia, thyroid carcinoma .

Cat. No.	Product Name

HY-L064

Glutamine Metabolism Compound Library	973 compounds
Glutamine is an important metabolic fuel that helps rapidly proliferating cells meet the increased demand for ATP, biosynthetic precursors, and reducing agents. Glutamine Metabolism pathway involves the initial deamination of glutamine by glutaminase(GLS), yielding glutamate and ammonia. Glutamate is converted to the TCA cycle intermediate α-ketoglutarate (α-KG) by either glutamate dehydrogenase (GDH) or by the alanine or aspartate transaminases (TAs), to produce both ATP and anabolic carbons for the synthesis of amino acids, nucleotides and lipids. During periods of hypoxia or mitochondrial dysfunction, α-KG can be converted to citrate in a reductive carboxylation reaction catalyzed by IDH2. The newly formed citrate exits the mitochondria where it is used to synthesize fatty acids and amino acids and produce the reducing agent, NADPH. Cancer cells display an altered metabolic circuitry that is directly regulated by oncogenic mutations and loss of tumor suppressors. Mounting evidence indicates that altered glutamine metabolism in cancer cells has critical roles in supporting macromolecule biosynthesis, regulating signaling pathways, and maintaining redox homeostasis, all of which contribute to cancer cell proliferation and survival. Thus, intervention in glutamine metabolic processes could provide novel approaches to improve cancer treatment. MCE owns a unique collection of 973 compounds targeting the mainly proteins and enzymes involved in glutamine metabolism pathway. Glutamine Metabolism compound library is a useful tool for intervention in glutamine metabolic processes.

Glutamine Metabolism Compound Library

973 compounds

Glutamine is an important metabolic fuel that helps rapidly proliferating cells meet the increased demand for ATP, biosynthetic precursors, and reducing agents. Glutamine Metabolism pathway involves the initial deamination of glutamine by glutaminase(GLS), yielding glutamate and ammonia. Glutamate is converted to the TCA cycle intermediate α-ketoglutarate (α-KG) by either glutamate dehydrogenase (GDH) or by the alanine or aspartate transaminases (TAs), to produce both ATP and anabolic carbons for the synthesis of amino acids, nucleotides and lipids. During periods of hypoxia or mitochondrial dysfunction, α-KG can be converted to citrate in a reductive carboxylation reaction catalyzed by IDH2. The newly formed citrate exits the mitochondria where it is used to synthesize fatty acids and amino acids and produce the reducing agent, NADPH.

Cancer cells display an altered metabolic circuitry that is directly regulated by oncogenic mutations and loss of tumor suppressors. Mounting evidence indicates that altered glutamine metabolism in cancer cells has critical roles in supporting macromolecule biosynthesis, regulating signaling pathways, and maintaining redox homeostasis, all of which contribute to cancer cell proliferation and survival. Thus, intervention in glutamine metabolic processes could provide novel approaches to improve cancer treatment.

MCE owns a unique collection of 973 compounds targeting the mainly proteins and enzymes involved in glutamine metabolism pathway. Glutamine Metabolism compound library is a useful tool for intervention in glutamine metabolic processes.

Cat. No.	Product Name	Type

HY-E70003

**Glutamate dehydrogenase**	Biochemical Assay Reagents
Glutamate dehydrogenase is an enzyme in both prokaryotes and eukaryotic mitochondria. Glutamate dehydrogenase can be used for the enzymatic determination of ammonia, alpha-ketoglutaric acid, L-glutamate and urease .

HY-134136A

Octanoyl coenzyme A lithium	Enzyme Substrates
Octanoyl coenzyme A lithium is a fatty acyl coenzyme A derivative. Octanoyl coenzyme A lithium can inhibit citrate synthase (CS) and **glutamate dehydrogenase (GDH) with IC₅₀** values of 0.4-1.6 mM .

HY-134136

Octanoyl Coenzyme A	Enzyme Substrates
Octanoyl coenzyme A is a fatty acyl coenzyme A derivative. Octanoyl coenzyme A can inhibit citrate synthase (CS) and glutamate dehydrogenase (GDH) with IC₅₀ values of 0.4-1.6 mM .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-12688A

Succinyl phosphonate trisodium salt 10+ Cited Publications	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Metabolic Disease Endogenous metabolite Disease Research Fields Cancer	Endogenous Metabolite Reactive Oxygen Species
Succinyl phosphonate trisodium salt is an α-ketoglutarate dehydrogenase (KGDHC) inhibitor, effective inhibits (KGDHC) in muscle, bacterial, brain, and cultured human fibroblasts . Succinyl phosphonate trisodium salt is an 2-oxoglutarate dehydrogenase (OGDH) inhibitor, impairs viability of cancer cells in a cell-specific metabolism-dependent manner . Succinyl phosphonate trisodium salt inhibits the glutamate-induced ROS production in glutamate-stimulated hippocampal neurons in situ .

HY-W040307B

Saccharopine hydrochloride L-Saccharopine hydrochloride	Structural Classification Natural Products Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite
Saccharopine (L-Saccharopine) hydrochloride, a lysine degradation intermediate, is a mitochondrial toxin. Lysine and α-ketoglutarate are converted into Saccharopine hydrochloride by the lysine-ketoglutarate reductase. Saccharopine hydrochloride is then oxidized to α-aminoapidate semialdehyde and glutamate by the saccharopine dehydrogenase. Saccharopine hydrochloride impairs development by disrupting mitochondrial homeostasis .

HY-13653

(-)-Epigallocatechin Gallate Maximum Cited Publications 34 Publications Verification EGCG; Epigallocatechol Gallate	Structural Classification Classification of Application Fields Anti-aging Source classification Plants Endogenous metabolite Flavonoids other families Flavonones Phenols Polyphenols Inflammation/Immunology Disease Research Fields Cancer	Endogenous Metabolite Apoptosis
(-)-Epigallocatechin Gallate (EGCG) is a major polyphenol in green tea, which can inhibit cell proliferation and induce cell apoptosis. (-)-Epigallocatechin Gallate inhibits glutamate dehydrogenase 1/2 (GDH1/2, GLUD1/2) activity. (-)-Epigallocatechin Gallate has a potent anticancer, antioxidant and anti-inflammatory properties against various types of cancers such as colorectal cancer, myeloid leukemia, thyroid carcinoma .

HY-13653R

(-)-Epigallocatechin Gallate (Standard) Maximum Cited Publications 34 Publications Verification EGCG(Standard); Epigallocatechol Gallate (Standard)	Structural Classification Flavonoids other families Classification of Application Fields Anti-aging Source classification Phenols Plants Endogenous metabolite Inflammation/Immunology Disease Research Fields Cancer	Endogenous Metabolite Apoptosis
(-)-Epigallocatechin Gallate (Standard) is the analytical standard of (-)-Epigallocatechin Gallate. This product is intended for research and analytical applications. (-)-Epigallocatechin Gallate (EGCG) is a major polyphenol in green tea, which can inhibit cell proliferation and induce cell apoptosis. (-)-Epigallocatechin Gallate inhibits glutamate dehydrogenase 1/2 (GDH1/2, GLUD1/2) activity. (-)-Epigallocatechin Gallate has a potent anticancer, antioxidant and anti-inflammatory properties against various types of cancers such as colorectal cancer, myeloid leukemia, thyroid carcinoma .

HY-12688

Succinyl phosphonate	Structural Classification Neurological Disease Classification of Application Fields Ketones, Aldehydes, Acids Source classification Endogenous metabolite Disease Research Fields	Endogenous Metabolite Reactive Oxygen Species
Succinyl phosphonate is an α-ketoglutarate dehydrogenase (KGDHC) inhibitor, effective inhibits (KGDHC) in muscle, bacterial, brain, and cultured human fibroblasts . Succinyl phosphonate trisodium salt is an 2-oxoglutarate dehydrogenase (OGDH) inhibitor, impairs viability of cancer cells in a cell-specific metabolism-dependent manner . Succinyl phosphonate trisodium salt inhibits the glutamate-induced ROS production in glutamate-stimulated hippocampal neurons in situ .

HY-W040307

Saccharopine L-Saccharopine	Structural Classification Natural Products Human Gut Microbiota Metabolites Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite
Saccharopine (L-Saccharopine), a lysine degradation intermediate, is a mitochondrial toxin. Lysine and α-ketoglutarate are converted into Saccharopine by the lysine-ketoglutarate reductase. Saccharopine is then oxidized to α-aminoapidate semialdehyde and glutamate by the saccharopine dehydrogenase. Saccharopine impairs development by disrupting mitochondrial homeostasis .

HY-150526

EGCG-4″-sulfate	Structural Classification Flavonoids Classification of Application Fields Flavanols Source classification Endogenous metabolite Inflammation/Immunology Disease Research Fields Cancer	Endogenous Metabolite Apoptosis
EGCG-4″-sulfate is a major polyphenol in green tea, which can inhibit cell proliferation and induce cell apoptosis. (-)-Epigallocatechin Gallate sulfate inhibits glutamate dehydrogenase 1/2 (GDH1/2, GLUD1/2) activity. EGCG-4″-sulfate has a potent anticancer, antioxidant and anti-inflammatory properties against various types of cancers such as colorectal cancer, myeloid leukemia, thyroid carcinoma .

Species:	Human (2)
Tag:	His (1) Tag Free (1)
Source:	E. coli (2)

Cat. No.	Compare	Product Name	Species	Source

HY-P701914

	GLUD1 Protein, Human GLUD1; glutamate dehydrogenase 1; mitochondrial; GDH 1	Human	E. coli
	GLUD1 protein is a mitochondrial glutamate dehydrogenase that converts L-glutamate into α-ketoglutarate, supporting glutamine anaplerosis and the tricarboxylic acid cycle. In addition to metabolism, GLUD1 plays a key role in insulin homeostasis, complexly regulating glucose metabolism. GLUD1 Protein, Human is the recombinant human-derived GLUD1 protein, expressed by E. coli , with tag free. The total length of GLUD1 Protein, Human is 505 a.a., .

HY-P701915

	GLUD1 Protein, Human (His) GLUD1; glutamate dehydrogenase 1; mitochondrial; GDH 1	Human	E. coli
	GLUD1 protein is a mitochondrial glutamate dehydrogenase that converts L-glutamate into α-ketoglutarate, supporting glutamine anaplerosis and the tricarboxylic acid cycle. In addition to metabolism, GLUD1 plays a key role in insulin homeostasis, complexly regulating glucose metabolism. GLUD1 Protein, Human (His) is the recombinant human-derived GLUD1 protein, expressed by E. coli , with N-6*His labeled tag. The total length of GLUD1 Protein, Human (His) is 505 a.a., .

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HY-13653S

(+/-)-Epigallocatechin Gallate-13C3
(+/-)-Epigallocatechin Gallate- ¹³C₃ is the ¹³C-labeled (-)-Epigallocatechin Gallate. (-)-Epigallocatechin Gallate is a tea flavonoid with potent antioxidant, antiinflammatory, and anticarcinogenic properties. (-)-Epigallocatechin Gallate is reported to inhibit EGFR signaling and thereby exert anticancer effects[1]. (-)-Epigallocatechin Gallate (EGCG) is a glutamate dehydrogenase 1/2 (GDH1/2, GLUD1/2) inhibitor. Epigallocatechin-3-gallate induces oxidative phosphorylation (OXPHOS) by activating cytochrome c oxidase.

(+/-)-Epigallocatechin Gallate-13C3

(+/-)-Epigallocatechin Gallate- ¹³C₃ is the ¹³C-labeled (-)-Epigallocatechin Gallate. (-)-Epigallocatechin Gallate is a tea flavonoid with potent antioxidant, antiinflammatory, and anticarcinogenic properties. (-)-Epigallocatechin Gallate is reported to inhibit EGFR signaling and thereby exert anticancer effects[1]. (-)-Epigallocatechin Gallate (EGCG) is a glutamate dehydrogenase 1/2 (GDH1/2, GLUD1/2) inhibitor. Epigallocatechin-3-gallate induces oxidative phosphorylation (OXPHOS) by activating cytochrome c oxidase.

HY-13653S1

(-)-Epigallocatechin Gallate-d4
(-)-Epigallocatechin Gallate-d4 (EGCG-d4) is the deuterium labeled (-)-Epigallocatechin Gallate (HY-13653). (-)-Epigallocatechin Gallate (EGCG) is a major polyphenol in green tea, which can inhibit cell proliferation and induce cell apoptosis. (-)-Epigallocatechin Gallate inhibits glutamate dehydrogenase 1/2 (GDH1/2, GLUD1/2) activity. (-)-Epigallocatechin Gallate has a potent anticancer, antioxidant and anti-inflammatory properties against various types of cancers such as colorectal cancer, myeloid leukemia, thyroid carcinoma .

(-)-Epigallocatechin Gallate-d4

(-)-Epigallocatechin Gallate-d4 (EGCG-d4) is the deuterium labeled (-)-Epigallocatechin Gallate (HY-13653). (-)-Epigallocatechin Gallate (EGCG) is a major polyphenol in green tea, which can inhibit cell proliferation and induce cell apoptosis. (-)-Epigallocatechin Gallate inhibits glutamate dehydrogenase 1/2 (GDH1/2, GLUD1/2) activity. (-)-Epigallocatechin Gallate has a potent anticancer, antioxidant and anti-inflammatory properties against various types of cancers such as colorectal cancer, myeloid leukemia, thyroid carcinoma .

Cat. No.	Compare	Product Name	Application	Reactivity

HY-P83281

	Glutamate Dehydrogenase 1 Antibody (YA3026) GDH; Gdh-X; GDH1; GLUD; Glud1; Glud1a; Glud1b; Gludl; MRG-2	WB, IHC-P, ICC/IF, FC	Human, Mouse, Rat
	Glutamate Dehydrogenase 1 Antibody (YA3026) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA3026), targeting Glutamate Dehydrogenase 1, with a predicted molecular weight of 61 kDa. Glutamate Dehydrogenase 1 Antibody (YA3026) can be used for WB, IHC-P, ICC/IF, FC experiment in human, mouse, rat background.

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