2. Metabolic Enzyme/Protease
  3. Endogenous Metabolite
  4. Saccharopine hydrochloride

Saccharopine hydrochloride  (Synonyms: L-Saccharopine hydrochloride)

Cat. No.: HY-W040307B Purity: 99.84%
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Saccharopine (L-Saccharopine) hydrochloride, a lysine degradation intermediate, is a mitochondrial toxin. Lysine and α-ketoglutarate are converted into Saccharopine hydrochloride by the lysine-ketoglutarate reductase. Saccharopine hydrochloride is then oxidized to α-aminoapidate semialdehyde and glutamate by the saccharopine dehydrogenase. Saccharopine hydrochloride impairs development by disrupting mitochondrial homeostasis.

For research use only. We do not sell to patients.

Saccharopine hydrochloride Chemical Structure

Saccharopine hydrochloride Chemical Structure

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5 mg USD 330 In-stock
10 mg USD 530 In-stock
25 mg USD 850 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of Saccharopine hydrochloride:

Saccharopine hydrochloride Related Antibodies

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Description

Saccharopine (L-Saccharopine) hydrochloride, a lysine degradation intermediate, is a mitochondrial toxin. Lysine and α-ketoglutarate are converted into Saccharopine hydrochloride by the lysine-ketoglutarate reductase. Saccharopine hydrochloride is then oxidized to α-aminoapidate semialdehyde and glutamate by the saccharopine dehydrogenase. Saccharopine hydrochloride impairs development by disrupting mitochondrial homeostasis[1][2][3].

IC50 & Target[1]

Human Endogenous Metabolite

 

In Vitro

Saccharopine accumulation leads to mitochondrial damage and functional loss which is induced by saccharopine dehydrogenase (SDH) mutations of α-aminoadipate semialdehyde synthase (AASS)-1 in C. elegans[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Saccharopine hydrochloride Related Antibodies
In Vivo

Saccharopine accumulation induces mitochondrial damage and progressive postnatal growth retardation in Aass mutant mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

312.75

Formula

C11H21ClN2O6
Appearance

Oil

Color

Colorless to off-white

SMILES

OC([C@H](CCC(O)=O)NCCCC[C@@H](C(O)=O)N)=O.[H]Cl
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

H2O : 250 mg/mL (799.36 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.1974 mL 15.9872 mL 31.9744 mL
5 mM 0.6395 mL 3.1974 mL 6.3949 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 3.1974 mL 15.9872 mL 31.9744 mL 79.9361 mL
5 mM 0.6395 mL 3.1974 mL 6.3949 mL 15.9872 mL
10 mM 0.3197 mL 1.5987 mL 3.1974 mL 7.9936 mL
15 mM 0.2132 mL 1.0658 mL 2.1316 mL 5.3291 mL
20 mM 0.1599 mL 0.7994 mL 1.5987 mL 3.9968 mL
25 mM 0.1279 mL 0.6395 mL 1.2790 mL 3.1974 mL
30 mM 0.1066 mL 0.5329 mL 1.0658 mL 2.6645 mL
40 mM 0.0799 mL 0.3997 mL 0.7994 mL 1.9984 mL
50 mM 0.0639 mL 0.3197 mL 0.6395 mL 1.5987 mL
60 mM 0.0533 mL 0.2665 mL 0.5329 mL 1.3323 mL
80 mM 0.0400 mL 0.1998 mL 0.3997 mL 0.9992 mL
100 mM 0.0320 mL 0.1599 mL 0.3197 mL 0.7994 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Saccharopine hydrochloride Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SaccharopineL-SaccharopineEndogenous MetabolitelysinedegradationintermediatemitochondrialtoxindevelopmenthomeostasisInhibitorinhibitorinhibit

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