Saccharopine (Synonyms: L-Saccharopine)

Cat. No.: HY-W040307: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Saccharopine (L-Saccharopine), a lysine degradation intermediate, is a mitochondrial toxin. Lysine and α-ketoglutarate are converted into Saccharopine by the lysine-ketoglutarate reductase. Saccharopine is then oxidized to α-aminoapidate semialdehyde and glutamate by the saccharopine dehydrogenase. Saccharopine impairs development by disrupting mitochondrial homeostasis.

The free form of the compound is prone to instability, it is advisable to consider the stable salt form (Saccharopine hydrochloride) that retains the same biological activity.

For research use only. We do not sell to patients.

Saccharopine Chemical Structure

CAS No. : 997-68-2

Size	Price	Stock
1 mg	USD 300	Ask For Quote & Lead Time

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Other Forms of Saccharopine:

Saccharopine hydrochloride Get quote

Featured Recommendations

•Related Small Molecules:

•Related Proteins:

Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target

Human Endogenous Metabolite

In Vitro

Saccharopine accumulation leads to mitochondrial damage and functional loss which is induced by saccharopine dehydrogenase (SDH) mutations of α-aminoadipate semialdehyde synthase (AASS)-1 in C. elegans^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Saccharopine accumulation induces mitochondrial damage and progressive postnatal growth retardation in Aass mutant mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

276.29

Formula

C₁₁H₂₀N₂O₆

CAS No.

997-68-2

Appearance

Solid

Color

White to off-white

SMILES

OC([C@@H](NCCCC[C@H](N)C(O)=O)CCC(O)=O)=O

Structure Classification

Others

Initial Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : 8.3 mg/mL (30.04 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.6194 mL	18.0969 mL	36.1939 mL
5 mM	0.7239 mL	3.6194 mL	7.2388 mL
10 mM	0.3619 mL	1.8097 mL	3.6194 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: ≥97.0%

Select Batch:

Data Sheet (269 KB) SDS (393 KB)

COA (243 KB) Elemental Analysis Report (102 KB)

Handling Instructions (2659 KB)

References

[1]. Zhou J, et, al. The lysine catabolite saccharopine impairs development by disrupting mitochondrial homeostasis. J Cell Biol. 2019 Feb 4;218(2):580-597. [Content Brief]

[2]. Leandro J, et, al. Saccharopine, a lysine degradation intermediate, is a mitochondrial toxin. J Cell Biol. 2019 Feb 4;218(2):391-392. [Content Brief]

[3]. Papes F, et, al. Lysine degradation through the saccharopine pathway in mammals: involvement of both bifunctional and monofunctional lysine-degrading enzymes in mouse. Biochem J. 1999 Dec 1;344 Pt 2(Pt 2):555-63. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.6194 mL	18.0969 mL	36.1939 mL	90.4846 mL
	5 mM	0.7239 mL	3.6194 mL	7.2388 mL	18.0969 mL
	10 mM	0.3619 mL	1.8097 mL	3.6194 mL	9.0485 mL
	15 mM	0.2413 mL	1.2065 mL	2.4129 mL	6.0323 mL
	20 mM	0.1810 mL	0.9048 mL	1.8097 mL	4.5242 mL
	25 mM	0.1448 mL	0.7239 mL	1.4478 mL	3.6194 mL
	30 mM	0.1206 mL	0.6032 mL	1.2065 mL	3.0162 mL

Saccharopine Related Classifications

Metabolic Disease

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Saccharopine997-68-2L-SaccharopineEndogenous MetabolitelysinedegradationintermediatemitochondrialtoxindevelopmenthomeostasisInhibitorinhibitorinhibit

Your Recently Viewed Products:

Product Name

Salutation

Applicant Name *

Email Address *

Phone Number *

Organization Name *

Department *

Requested quantity *

Country or Region *

Remarks