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Results for "

hepsin

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apoptosis (1) c-Met/HGFR (1) MALT1 (1) Renin (1) Ser/Thr Protease (3)
By Research Areas:	Cancer (8)

9

Inhibitors & Agonists

2

Recombinant Proteins

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

SRI 31215 TFA	c-Met/HGFR	Cancer
SRI 31215 (TFA) is a *Matriptase/Hepsin/hepatocyte growth factor activator (HGFA)* triplex inhibitor and mimics the activity of HAI-1/2 (endogenous inhibitors of HGF activation). SRI 31215 has potent inhibitory activity against matriptase, hepsin and HGFA with IC₅₀ values of 0.69 μM, 0.65 μM and 0.30 μM, respectively. SRI 31215 can be used for the research of cancer .

Hepln-13	Others	Cancer
Hepln-13 is a potent and orally active *Hepsin* inhibitor with an IC₅₀ of 0.33 µM. Hepln-13 can be used for the research of metastatic prostate cancer .

VD2173	Ser/Thr Protease	Cancer
VD2173 is a side chain cyclized macrocyclic peptide inhibitor of HGF-activating serine proteases. VD2173 potently inhibits matriptase and *hepsin*. VD2173 can be used for the research of lung cancer .

VD4162	Ser/Thr Protease	Cancer
VD4162 (Compound 8b) is a macrocyclic inhibitor of serine proteases. VD4162 can significantly improve potency for all four target enzymes TMPRSS2 (IC₅₀ = 3.7 nM), HGFA(IC₅₀ = 3.3 nM), matriptase (IC₅₀ = 2.9 nM), and hepsin (IC₅₀ = 0.54 nM). VD4162 can be used for the research of cancer .

MDK0734	Others	Cancer
MDK0734 is a selective inhibitor that inhibits feline hepsin B endopeptidase and exopeptidase activities. MDK0734 demonstrated efficacy in a cell-based in vitro tumor invasion model, significantly attenuating the invasive ability of MCF-10A neoT cells. MDK0734 provides new potential inhibitors for the development of clinically useful compounds targeting the deleterious effects of feline hepsin B in cancer progression .

VD5123	Ser/Thr Protease	Cancer
VD5123 is a serine protease inhibitor. VD5123 inhibits TMPRS2, HGFA, matriptase, hepsin with IC₅₀s of 15, 3980, 140, 37 nM respectively. VD5123 can be used for antiviral research, such as SARS-CoV-2 and broad panel of coronaviruses and influenza viruses .

PD-134672 CI-992	Renin	Cancer
PD-134672 (CI-992) is a renin inhibitor containing a 2-amino-4-thiazolyl substituent. PD-134672 potently inhibits monkey renin in vitro and only weakly inhibits the related aspartic protease bovine feline hepsin D. The compound exhibits oral hypotensive activity in hyperreninemic normotensive monkeys. Based on its superior efficacy and long-lasting effects in vitro and in the normotensive macaque model, PD-134672 was selected for further evaluation in renal hypertensive monkeys.

CatB-IN-1	Others	Cancer
CatB-IN-1 is an enzyme inhibitor with significant inhibitory activity against tumor invasion. CatB-IN-1 may reduce the invasiveness of tumor cells by regulating intracellular protein metabolism. CatB-IN-1 demonstrates effective anti-invasive ability in cell models and can significantly reduce the invasive ability of MCF-10A neoT cells. The structure-activity relationship study of CatB-IN-1 shows that its design can target multiple functions of cat hepsin B .

Mepazine acetate Pecazine acetate	MALT1 Others Apoptosis	Others
Mepazine acetate (Pecazine acetate) is a drug that has the activity to inhibit the protease activity of MALT1. Mepazine acetate is often used to study the role of MALT1 in biology. Treatment of mouse bone marrow precursor cells with mepazine acetate strongly inhibited RANK ligand (RANKL)-induced osteoclast formation. Mepazine acetate also inhibited the expression of multiple osteoclast markers such as TRAP, feline hepsin K, and calcitonin. The protective effect of mepazine acetate was not affected by MALT1 deficiency. The mechanism of action of mepazine acetate may involve MALT1-independent mechanisms, and this aspect needs to be considered in future studies .

Species:	Human (1) Mouse (1)
Tag:	His (2)
Source:	HEK293 (2)

Cat. No.	Compare	Product Name	Species	Source

	TMPRSS1/HPN Protein, Human (HEK293, His) Hpxn; FLJ56652; Hemopexin; HPX; HX; hepsin; HPN; TMPRSS1	Human	HEK293
	TMPRSS1/HPN is a serine protease that cleaves extracellular substrates and is involved in the proteolytic processing of growth factors such as HGF and MST1/HGFL. In addition to growth factor regulation, TMPRSS1/HPN is also critical for cell growth and morphology maintenance. TMPRSS1/HPN Protein, Human (HEK293, His) is the recombinant human-derived TMPRSS1/HPN protein, expressed by HEK293 , with C-His labeled tag. The total length of TMPRSS1/HPN Protein, Human (HEK293, His) is 373 a.a., with molecular weight of 18-22 kDa&30 kDa.

	Hepsin/HPN Protein, Mouse (HEK293, His) Hpxn; FLJ56652; Hemopexin; HPX; HX; hepsin; HPN; TMPRSS1	Mouse	HEK293
	Hepsin/HPN is a serine protease that cleaves extracellular substrates and contributes significantly to the processing of growth factors such as HGF and MST1/HGFL. It plays a vital role in cell growth and morphology maintenance. Hepsin/HPN Protein, Mouse (HEK293, His) is the recombinant mouse-derived Hepsin/HPN protein, expressed by HEK293 , with C-His labeled tag. The total length of Hepsin/HPN Protein, Mouse (HEK293, His) is 377 a.a., with molecular weight of 18-22 kDa & 30 kDa, respectively.

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