TMPRSS1/HPN Protein, Human (HEK293, His)

TMPRSS1/HPN is a serine protease that cleaves extracellular substrates and is involved in the proteolytic processing of growth factors such as HGF and MST1/HGFL. In addition to growth factor regulation, TMPRSS1/HPN is also critical for cell growth and morphology maintenance. TMPRSS1/HPN Protein, Human (HEK293, His) is the recombinant human-derived TMPRSS1/HPN protein, expressed by HEK293 , with C-His labeled tag. The total length of TMPRSS1/HPN Protein, Human (HEK293, His) is 373 a.a., with molecular weight of 18-22 kDa&30 kDa.

TMPRSS1/HPN, a serine protease, is involved in the cleavage of various extracellular substrates, contributing to the proteolytic processing of growth factors such as HGF and MST1/HGFL. Beyond its role in growth factor regulation, TMPRSS1/HPN plays a significant part in cell growth and the maintenance of cell morphology. Additionally, this protease is implicated in the proteolytic processing of ACE2, emphasizing its involvement in crucial cellular pathways. Notably, TMPRSS1/HPN mediates the proteolytic cleavage of urinary UMOD, a process essential for the polymerization of UMOD, underscoring its multifunctional role in modulating various biological processes.

Immobilized Human HPN, His Tag at 2 μg/mL (100 μl/Well) on the plate. Dose response curve for Anti-HPN Antibody, hFc Tag with the EC₅₀ of ≤20.0 ng/mL determined by ELISA.

Human

HEK293

C-His

P05981 (R45-L417)

3249  [NCBI]

18-22 kDa&30 kDa

Greater than 95% as determined by Tris-Bis PAGE.

Lyophilized powder.

Lyophilized from 0.22 μm filtered solution in 20 mM NaAc,150 mM NaCl (pH 5.0). Normally 8% trehalose is added as protectant before lyophilization.

<1 EU/μg, determined by LAL method.

Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in 20 mM NaAc,150 mM NaCl (pH 5.0).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.