Hepsin/HPN Protein, Mouse (HEK293, His)

Hepsin/HPN is a serine protease that cleaves extracellular substrates and contributes significantly to the processing of growth factors such as HGF and MST1/HGFL. It plays a vital role in cell growth and morphology maintenance. Hepsin/HPN Protein, Mouse (HEK293, His) is the recombinant mouse-derived Hepsin/HPN protein, expressed by HEK293 , with C-His labeled tag. The total length of Hepsin/HPN Protein, Mouse (HEK293, His) is 377 a.a., with molecular weight of 18-22 kDa & 30 kDa, respectively.

Hepsin/HPN, a serine protease, serves as a pivotal enzyme in the cleavage of extracellular substrates, contributing significantly to the proteolytic processing of growth factors like HGF and MST1/HGFL. Its involvement extends to key cellular functions, playing a crucial role in cell growth and the maintenance of cell morphology. Moreover, Hepsin/HPN is implicated in the proteolytic processing of ACE2, suggesting its participation in essential cellular pathways. Notably, this protease also mediates the cleavage of urinary UMOD, an integral step for the polymerization of UMOD, highlighting its diverse functions in modulating various biological processes.

Mouse

HEK293

C-His

O35453 (T60-P436)

15451  [NCBI]

18-22 kDa&30 kDa

Greater than 95% as determined by Tris-Bis PAGE.

<1 EU/μg, determined by LAL method.