Hepsin/HPN Protein, Mouse (HEK293, His)

Hepsin/HPN is a serine protease that cleaves extracellular substrates and contributes significantly to the processing of growth factors such as HGF and MST1/HGFL. It plays a vital role in cell growth and morphology maintenance. Hepsin/HPN Protein, Mouse (HEK293, His) is the recombinant mouse-derived Hepsin/HPN protein, expressed by HEK293 , with C-His labeled tag. The total length of Hepsin/HPN Protein, Mouse (HEK293, His) is 377 a.a., with molecular weight of 18-22 kDa & 30 kDa, respectively.

Hepsin/HPN, a serine protease, serves as a pivotal enzyme in the cleavage of extracellular substrates, contributing significantly to the proteolytic processing of growth factors like HGF and MST1/HGFL. Its involvement extends to key cellular functions, playing a crucial role in cell growth and the maintenance of cell morphology. Moreover, Hepsin/HPN is implicated in the proteolytic processing of ACE2, suggesting its participation in essential cellular pathways. Notably, this protease also mediates the cleavage of urinary UMOD, an integral step for the polymerization of UMOD, highlighting its diverse functions in modulating various biological processes.

The enzyme activity of this recombinant protein is testing in progress, we cannot offer a guarantee yet.

Mouse

HEK293

C-His

O35453 (T60-P436)

15451  [NCBI]

18-22 kDa&30 kDa

Greater than 95% as determined by Tris-Bis PAGE.

Lyophilized powder.

Lyophilized from a 0.2 μm filtered solution of 20mM NaAc,150mM NaCl (pH 5.0). Normally 8% trehalose is added as protectant before lyophilization.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.