1. Recombinant Proteins
  2. Enzymes & Regulators
  3. Hydrolases (EC 3)
  4. Hepsin/HPN Protein, Mouse (HEK293, His)

Hepsin/HPN Protein, Mouse (HEK293, His)

Cat. No.: HY-P77961
Handling Instructions

Hepsin/HPN is a serine protease that cleaves extracellular substrates and contributes significantly to the processing of growth factors such as HGF and MST1/HGFL. It plays a vital role in cell growth and morphology maintenance. Hepsin/HPN Protein, Mouse (HEK293, His) is the recombinant mouse-derived Hepsin/HPN protein, expressed by HEK293 , with C-His labeled tag. The total length of Hepsin/HPN Protein, Mouse (HEK293, His) is 377 a.a., with molecular weight of 18-22 kDa & 30 kDa, respectively.

For research use only. We do not sell to patients.

Surface Plasmon Resonance (SPR) Assay Service   Protein Expression Service

Size Stock
50 μg   Get quote  
100 μg   Get quote  

* Please select Quantity before adding items.

Top Publications Citing Use of Products
  • Biological Activity

  • Technical Parameters

  • Properties

  • Documentation

Description

Hepsin/HPN is a serine protease that cleaves extracellular substrates and contributes significantly to the processing of growth factors such as HGF and MST1/HGFL. It plays a vital role in cell growth and morphology maintenance. Hepsin/HPN Protein, Mouse (HEK293, His) is the recombinant mouse-derived Hepsin/HPN protein, expressed by HEK293 , with C-His labeled tag. The total length of Hepsin/HPN Protein, Mouse (HEK293, His) is 377 a.a., with molecular weight of 18-22 kDa & 30 kDa, respectively.

Background

Hepsin/HPN, a serine protease, serves as a pivotal enzyme in the cleavage of extracellular substrates, contributing significantly to the proteolytic processing of growth factors like HGF and MST1/HGFL. Its involvement extends to key cellular functions, playing a crucial role in cell growth and the maintenance of cell morphology. Moreover, Hepsin/HPN is implicated in the proteolytic processing of ACE2, suggesting its participation in essential cellular pathways. Notably, this protease also mediates the cleavage of urinary UMOD, an integral step for the polymerization of UMOD, highlighting its diverse functions in modulating various biological processes.

Species

Mouse

Source

HEK293

Tag

C-His

Accession

O35453 (T60-P436)

Gene ID
Molecular Construction
N-term
Hepsin (T60-P436)
Accession # O35453
His
C-term
Synonyms
Hpxn; FLJ56652; Hemopexin; HPX; HX; Hepsin; HPN; TMPRSS1
Molecular Weight

18-22 kDa&30 kDa

Purity

Greater than 95% as determined by Tris-Bis PAGE.

Endotoxin Level

<1 EU/μg, determined by LAL method.

Documentation

Hepsin/HPN Protein, Mouse (HEK293, His) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • Reconstitution Calculator

  • Dilution Calculator

  • Specific Activity Calculator

The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

 

Salutation

Applicant Name *

 

Email Address *

Phone Number *

 

Organization Name *

Department *

 

Requested quantity *

Country or Region *

     

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
Hepsin/HPN Protein, Mouse (HEK293, His)
Cat. No.:
HY-P77961
Quantity:
MCE Japan Authorized Agent: