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Results for "

integrated stress response

" in MedChemExpress (MCE) Product Catalog:

11

Inhibitors & Agonists

1

Biochemical Assay Reagents

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-153074
    ISR-IN-1

    		Others Cancer
    ISR-IN-1 (Compound 48) is an inhibitor of the integrated stress response (EC50: 0.6 nM) .
    ISR-IN-1
  • HY-153075
    ISR-IN-2

    		Others Cancer
    ISR-IN-2 (Compound 47) is an inhibitor of the integrated stress response (EC50: 0.8 nM) .
    ISR-IN-2
  • HY-149555
    DNL343

    		Eukaryotic Initiation Factor (eIF) Neurological Disease
    DNL343 is a brain-penetrating activator of eukaryotic initiation factor 2B (eIF2B) that inhibits the abnormal integrated stress response (ISR). DNL343 inhibits ISR activity in the central nervous system (CNS) and reverses neurodegeneration and neuroinflammation. DNL343 also prevents motor dysfunction and premature death in eIF2B loss-of-function (LOF) mutant mice. DNL343 has inhibitory potential in studies of vanishing white matter disease (VWMD) driven by eIF2B LOF and chronic ISR activation .
    DNL343
  • HY-153339
    E235

    		Others Cancer
    E235 is an expression regulator of activates transcription factor 4 (ATF4). E235 reduces cell viability by activating integrated stress response (ISR) and DNA damage response signals. E235 has anti-proliferative activity and can be used for tumor research .
    E235
  • HY-12495A
    ISRIB
    5+ Cited Publications

    		 Biochemical Assay Reagents Eukaryotic Initiation Factor (eIF) Neurological Disease
    ISRIB is a brain-penetrant inhibitor of integrated stress response (ISR). Persistent activation of the ISR has been linked to the development of several neurological disorders as ISR represses translation through inhibiting eIF2B. ISRIB inhibits the ISR by promoting the nucleotide exchange activity of eIF2B and recovering the translation, and thus can be used for neurological disorders research .
    ISRIB
  • HY-153399
    Fosigotifator

    		Others Cancer
    Fosigotifator is modulates the integrated stress response (ISR) for inhibition of ISR-related diseases .
    Fosigotifator
  • HY-164026
    ISR modulator-1

    		Others Cancer
    ISR modulator-1 (Compound 212) is a modulator for integrated stress response pathway (ISR)
    ISR modulator-1
  • HY-153399A
    ABBV-CLS-7262

    Fosigotifator THAM sodium

    		 Others Cancer
    ABBV-CLS-7262 is modulates the integrated stress response (ISR) for inhibition of ISR-related diseases .
    ABBV-CLS-7262
  • HY-158198
    PRXS571

    		Others Neurological Disease
    PRXS571 is a potent modulator of the neuronal integrated stress response (ISR) and can be used in neural-related research .
    PRXS571
  • HY-162863
    ERK-MYD88 interaction inhibitor 1

    		Apoptosis Cancer
    ERK-MYD88 interaction inhibitor 1 is an ERK-MYD88 interaction inhibitor. ERK-MYD88 interaction inhibitor 1 can induce an HRI-mediated integrated stress response (ISR), leading to cancer cell-specific immunogenic cell apoptosis (apoptosis). ERK-MYD88 interaction inhibitor 1 can induce anti-tumor T cell responses in Lewis lung cancer mice, exhibiting anti-tumor activity .
    ERK-MYD88 interaction inhibitor 1
  • HY-125021
    2BAct
    1 Publications Verification

    		 Eukaryotic Initiation Factor (eIF) Neurological Disease
    2BAct is a highly selective, and orally active eIF2B (eukaryotic initiation factor 2B) activator with an EC50 of 33 nM. 2BAct prevents neurological defects caused by a chronic integrated stress response. 2BAct is able to penetrate the central nervous system (CNS). 2BAct displays improved solubility and pharmacokinetics relative to eIF2B activator ISRIB trans-isomer (HY-12495) .
    2BAct

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