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Pathways Recommended:	Protein Tyrosine Kinase/RTK

Results for "

tyrphostin tyrosine kinase

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apoptosis (1) Autophagy (1) Bcr-Abl (1) c-Kit (1) c-Met/HGFR (1) Casein Kinase (1) CDK (1) EGFR (13) GPR35 (1) HCV (2) IGF-1R (1) Influenza Virus (3) JAK (2) PDGFR (2) Phosphatase (1) Ras (1) Ser/Thr Protease (1) STAT (2) Topoisomerase (1) Trk Receptor (1) Tyrosinase (2) VEGFR (2)
By Research Areas:	Cancer (18) Cardiovascular Disease (2) Infection (3) Inflammation/Immunology (2) Metabolic Disease (5)

Targets Recommended: Btk Syk DYRK Pyk2 BRK FAK FLT3 Anaplastic lymphoma kinase (ALK)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-W174279

Tyrphostin 8	EGFR Ras Phosphatase	Metabolic Disease
Tyrphostin 8 is a **tyrosine kinase, with an IC₅₀** of 560 μM for EGFR kinase. Tyrphostin 8 is also a GTPase inhibitor. Tyrphostin 8 can inhibit the protein serine/threonine phosphatase calcineurin (IC₅₀=21 μM) .

HY-101961

Tyrphostin AG 1288 AG 1288	c-Kit	Inflammation/Immunology
Tyrphostin AG 1288 is a potent **Tyrosine Kinase** inhibitor. Tyrphostin AG 1288 inhibits ICAM1 expression and TNFα-mediated cytotoxicity in vitro .

HY-20878

Tyrphostin AG 879 2 Publications Verification AG 879	Trk Receptor EGFR Apoptosis	Cancer
Tyrphostin AG 879 (AG 879) is a tyrosine kinase inhibitor that inhibits TrKA phosphorylation (IC₅₀ of 10 μM), but not TrKB and TrKC. Tyrphostin AG 879 is also a selective ErbB2 tyrosine kinase inhibitor with an IC₅₀ of 1 μM, and has at least 500-fold higher selectivity to ErbB2 than EGFR. Tyrphostin AG 879 has anticancer activity .

HY-101958

Tyrphostin 25 AG82; tyrphostin A 25; tyrphostin AG 82; RG-50875	EGFR GPR35	Inflammation/Immunology Cancer
Tyrphostin 25 (AG82) is a specific inhibitor of the EGFR tyrosine kinase. Tyrphostin 25 is also a GPR35 agonist with an IC₅₀ of 0.94 µM and an EC₅₀ of 5.3 µM .

HY-15511

Tyrphostin A9 3 Publications Verification tyrphostin 9; Malonoben	VEGFR Influenza Virus PDGFR	Infection Cancer
Tyrphostin A9, a PDGFR inhibitor, is a potent inducer of mitochondrial fission. Tyrphostin A9 emerged as the most potent and selective of 51 tyrosine kinase inhibitors tested against the TNF-induced respiratory burst. Tyrphostin A9 has anti-influenza virus activities.

HY-118964

Tyrphostin AG 568	Others	Others
Tyrphostin AG 568 is a **tyrphostin tyrosine kinase** inhibitor that induces erythroid differentiation. Tyrphostin AG 568 can be utilized in research related to autologous bone marrow transplantation .

HY-100962A

AG 99 tyrphostin 46; tyrphostin AG 99	Tyrosinase	Cancer
AG 99 (Tyrphostin 46), a tyrphostin derivative, is a **tyrosine kinase** inhibitor that increases sister chromatid exchange frequency in transformed CHO-K1 and primary CHE cells. AG 99 is promising for research of proliferative diseases .

HY-101959A

Tyrphostin 47	Ser/Thr Protease	Cancer
Tyrphostin 47 is a nonspecific inhibitor of WNK1. Tyrphostin 47 is a protein tyrosine kinase inhibitor. Tyrphostin 47 inhibits smooth-muscle cell proliferation

HY-101959

Tyrphostin AG213 AG213	EGFR Topoisomerase	Cancer
Tyrphostin AG213 (AG213) is an inhibitor of epidermal growth factor receptor (EGFR) protein tyrosine kinase (IC₅₀=0.85 μM). Tyrphostin AG213 inhibits tyrosine kinase activity IC₅₀=2.4 μM) and topoisomerase II (IC₁₀₀=50 μM). Tyrphostin AG213 can induce nonapoptotic cell programmed death in tumor cells .

HY-125350

Entacapone acid tyrphostin AG1290	c-Met/HGFR	Metabolic Disease
Entacapone acid (Tyrphostin AG1290) is a **tyrosine kinase** inhibitor. Entacapone acid reduces hepatic protein synthesis rate (HPS) in vivo .

HY-12000

AG490 Maximum Cited Publications 129 Publications Verification tyrphostin AG490; tyrphostin B42	EGFR STAT JAK Autophagy	Cancer
AG490 (Tyrphostin AG490) is a tyrosine kinase inhibitor that inhibits EGFR, Stat-3 and JAK2/3.

HY-101960A

Tyrphostin A51 1 Publications Verification AG-183	EGFR	Cancer
Tyrphostin A51 is a potent *protein tyrosine* kinase (PTK)** inhibitor. Tyrphostin A51 inhibits the volume-dependent release of [ ³H]taurine in a dose-dependent manner. Tyrphostin A51 markedly reduces cellular tyrosyl phosphorylation level. Tyrphostin A51 inhibits both basal and EGF-induced human bone cell proliferation .

HY-101960

(Z)-Tyrphostin A51 (Z)-AG-183	EGFR	Others
(Z)-Tyrphostin A51 is the Z configuration of Lanoconazole A51. Tyrphostin A51 is a potent *protein tyrosine* kinase (PTK)** inhibitor. Tyrphostin A51 inhibits the volume-dependent release of [ ³H]taurine in a dose-dependent manner. Tyrphostin A51 markedly reduces cellular tyrosyl phosphorylation level. Tyrphostin A51 inhibits both basal and EGF-induced human bone cell proliferation .

HY-117718

AG957 tyrphostin AG957; NSC 654705	Bcr-Abl	Cancer
AG957 (Tyrphostin AG957;NSC 654705) is a tyrosine kinase inhibitor with anti-BCR/ABL tyrosine kinase activity . AG957 is a bcr/abl kinase inhibitor with an IC₅₀ of 2.9 μM for p210 ^bcr/abl autokinase activity .

HY-120036

Tyrphostin AG1112	Casein Kinase Tyrosinase	Cancer
Tyrphostin AG1112 is a potent inhibitors of CK II. Tyrphostin AG1112 inhibits p210 ^bcr-abl tyrosine kinase, with IC₅₀ values of 2, 15, 20 μM in p210 ^bcr-abl, EGFR and PDGFR cells, respectively .

HY-100499

Tyrphostin AG 528 1 Publications Verification tyrphostin B66; AG 528	EGFR	Cancer
Tyrphostin AG 528 is an inhibitor of EGFR and ErbB2 with IC₅₀s of 4.9 and 2.1 μM, respectively. Tyrphostin AG 528 (Tyrphostin B66) is a protein tyrosine kinase inhibitor, with IC₅₀s of 4.9 μM for epidermal growth factor receptors (EGFR) and 2.1 μM for ErbB2 . Tyrphostin AG 528 is also an anticancer agent .

HY-118532

Tyrphostin AG30 1 Publications Verification AG30	EGFR	Cancer
Tyrphostin AG30 (AG30) is a potent and selective EGFR tyrosine kinase inhibitor. Tyrphostin AG30 (AG30) selectively inhibits self renewal induction by c-ErbB, and is able to inhibit activation of STAT5 by c-ErbB in primary erythroblasts .

HY-13524

AG-1478 35+ Cited Publications tyrphostin AG-1478; NSC 693255	EGFR HCV Influenza Virus	Infection Cardiovascular Disease Metabolic Disease Cancer
AG-1478 (Tyrphostin AG-1478) is a selective EGFR tyrosine kinase inhibitor with IC₅₀ of 3 nM. AG-1478 has antiviral effects against HCV and encephalomyocarditis virus (EMCV).

HY-135680

I-OMe-Tyrphostin AG 538 I-OMe-AG 538	IGF-1R	Metabolic Disease Cancer
I-OMe-Tyrphostin AG 538 (I-OMe-AG 538) is a specific inhibitor of IGF-1R (insulin-like growth factor-1 receptor tyrosine kinase). I-OMe-Tyrphostin AG 538 inhibits IGF-1R-mediated signaling and is preferentially cytotoxic to nutrient-deprived PANC1 cells. I-OMe-Tyrphostin AG 538 is an ATP-competitive inhibitor of *phosphatidylinositol-5-phosphate 4-kinase* α (PI5P4Kα), with an IC₅₀** of 1 µM .

HY-119757

Tyrphostin AG1433 SU1433; AG1433	PDGFR VEGFR	Cancer
Tyrphostin AG1433 (SU1433) is a **tyrosine kinases inhibitor. AG1433 is also a selective PDGFRβ and VEGFR-2 (Flk-1/KDR) inhibitor with IC₅₀*s of 5.0 μM and 9.3 μM, respectively. Tyrphostin* AG1433 prevents blood vessel formation .

HY-13524A

AG-1478 hydrochloride tyrphostin AG-1478 hydrochloride; NSC 693255 hydrochloride	EGFR HCV Influenza Virus	Infection Cardiovascular Disease Metabolic Disease Cancer
AG-1478 hydrochloride (Tyrphostin AG-1478 hydrochloride) is a selective EGFR tyrosine kinase inhibitor with IC₅₀ of 3 nM. AG-1478 hydrochloride has antiviral effects against HCV and encephalomyocarditis virus (EMCV) .

HY-107459

(E/Z)-AG490 (E/Z)-tyrphostin AG490; (E/Z)-tyrphostin B42	EGFR STAT JAK	Cancer
(E/Z)-AG490 ((E/Z)-Tyrphostin AG490) is a racemic compound of (E)-AG490 and (Z)-AG490 isomers. (E)-AG490 (HY-12000) is a **tyrosine kinase inhibitor that inhibits EGFR, Stat-3 and JAK2/3**.

HY-101042

AG-494 tyrphostin AG 494	EGFR CDK	Cancer
AG-494 (Tyrphostin AG 494) is a potent and selective EGFR tyrosine kinase inhibitor (IC₅₀=0.7 μM). AG-494 inhibits the autophosphorylation of EGFR, ErbB2, HER1-2 and PDGF-R with IC₅₀s 1.1, 39, 45 and 6 μM, respectively. AG-494 blocks Cdk2 activation and inhibits EGF-dependent DNA synthesis .

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tyrphostin tyrosine kinase

Inhibitors & Agonists