2. JAK/STAT Signaling Protein Tyrosine Kinase/RTK Cell Cycle/DNA Damage
  3. EGFR Topoisomerase
  4. Tyrphostin AG213

Tyrphostin AG213 (AG213) is an inhibitor of epidermal growth factor receptor (EGFR) protein tyrosine kinase (IC50=0.85 μM). Tyrphostin AG213 inhibits tyrosine kinase activity IC50=2.4 μM) and topoisomerase II (IC100=50 μM). Tyrphostin AG213 can induce nonapoptotic cell programmed death in tumor cells.

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Tyrphostin AG213 Chemical Structure

Tyrphostin AG213 Chemical Structure

CAS No. : 122520-86-9

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Based on 1 publication(s) in Google Scholar

Other Forms of Tyrphostin AG213:

Tyrphostin AG213 Related Antibodies

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Description

Tyrphostin AG213 (AG213) is an inhibitor of epidermal growth factor receptor (EGFR) protein tyrosine kinase (IC50=0.85 μM). Tyrphostin AG213 inhibits tyrosine kinase activity IC50=2.4 μM) and topoisomerase II (IC100=50 μM). Tyrphostin AG213 can induce nonapoptotic cell programmed death in tumor cells[1][2][3].

In Vitro

Tyrphostin AG213 (25 μM, 50 μM, and 75 μM; 24 h, 48 h, and 96 h) increases wound closure time in human umbilical vein endothelial cell (HUVEC) monolayer[1].
Tyrphostin AG213 (100 μM; 1 h) interferes with HUVEC focal adhesion and stress fiber formation[1].
Tyrphostin AG213 (100 μM; 24 h) inhibits adherence-related tyrosine phosphorylation of pp125FAK in HUVEC[1].
Tyrphostin AG213 (10 μM; 24 h) inhibits tyrosine kinase activity, and (4.55-455 mM; 24-72 h) inhibits HT-29 cell viability dose- and time-dependently[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Tyrphostin AG213 Related Antibodies
Molecular Weight

220.25

Formula

C10H8N2O2S
CAS No.
SMILES

S=C(N)/C(C#N)=C/C1=CC=C(O)C(O)=C1.[(E)]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Tyrphostin AG213 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tyrphostin AG213122520-86-9AG213Tyrphostin AG 213Tyrphostin AG-213AG 213AG-213EGFRTopoisomeraseEpidermal growth factor receptorErbB-1HER1Inhibitorinhibitorinhibit

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