2. Protein Tyrosine Kinase/RTK
  3. c-Kit
  4. Tyrphostin AG 1288

Tyrphostin AG 1288  (Synonyms: AG 1288)

Cat. No.: HY-101961 Purity: 98.68%
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Tyrphostin AG 1288 is a potent Tyrosine Kinase inhibitor. Tyrphostin AG 1288 inhibits ICAM1 expression and TNFα-mediated cytotoxicity in vitro.

For research use only. We do not sell to patients.

Tyrphostin AG 1288 Chemical Structure

Tyrphostin AG 1288 Chemical Structure

CAS No. : 116313-73-6

Size Price Stock Quantity
5 mg USD 35 In-stock
10 mg USD 55 In-stock
25 mg USD 110 In-stock
50 mg USD 165 In-stock
100 mg USD 260 In-stock
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Based on 1 publication(s) in Google Scholar

Tyrphostin AG 1288 Related Antibodies

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Description

Tyrphostin AG 1288 is a potent Tyrosine Kinase inhibitor. Tyrphostin AG 1288 inhibits ICAM1 expression and TNFα-mediated cytotoxicity in vitro[1].

Molecular Weight

231.16

Formula

C10H5N3O4
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

N#C/C(C#N)=C/C1=CC([N+]([O-])=O)=C(O)C(O)=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 125 mg/mL (540.75 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.3260 mL 21.6300 mL 43.2601 mL
5 mM 0.8652 mL 4.3260 mL 8.6520 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 4.3260 mL 21.6300 mL 43.2601 mL 108.1502 mL
5 mM 0.8652 mL 4.3260 mL 8.6520 mL 21.6300 mL
10 mM 0.4326 mL 2.1630 mL 4.3260 mL 10.8150 mL
15 mM 0.2884 mL 1.4420 mL 2.8840 mL 7.2100 mL
20 mM 0.2163 mL 1.0815 mL 2.1630 mL 5.4075 mL
25 mM 0.1730 mL 0.8652 mL 1.7304 mL 4.3260 mL
30 mM 0.1442 mL 0.7210 mL 1.4420 mL 3.6050 mL
40 mM 0.1082 mL 0.5408 mL 1.0815 mL 2.7038 mL
50 mM 0.0865 mL 0.4326 mL 0.8652 mL 2.1630 mL
60 mM 0.0721 mL 0.3605 mL 0.7210 mL 1.8025 mL
80 mM 0.0541 mL 0.2704 mL 0.5408 mL 1.3519 mL
100 mM 0.0433 mL 0.2163 mL 0.4326 mL 1.0815 mL
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Tyrphostin AG 1288 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tyrphostin AG 1288116313-73-6AG 1288Tyrphostin AG1288Tyrphostin AG-1288AG1288AG-1288c-KitSCFRCD117Guanylate Cyclasetyrosine kinaseA549EAhy926. IntegrinInhibitorinhibitorinhibit

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