THP-PEG6-OH

Cat. No.: HY-126918: FAQs
Data Sheet Handling Instructions

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THP-PEG6-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. THP-PEG6-OH is also a non-cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

For research use only. We do not sell to patients.

THP-PEG6-OH Chemical Structure

CAS No. : 42607-87-4

Size	Price	Stock
50 mg	USD 40	Ask For Quote & Lead Time
100 mg	USD 56	Ask For Quote & Lead Time
250 mg	USD 93	Ask For Quote & Lead Time
1 g	USD 202	Ask For Quote & Lead Time

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Biological Activity
Purity & Documentation
References
Customer Review

Description

THP-PEG6-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs^[1]. THP-PEG6-OH is also a non-cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)^[2].

IC₅₀ & Target

PEGs	Non-cleavable Linker

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins^[1].
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

366.45

Formula

C₁₇H₃₄O₈

CAS No.

42607-87-4

Appearance

Liquid (Density: 1.10±0.1 g/cm³)

Color

Colorless to light yellow

SMILES

OCCOCCOCCOCCOCCOCCOC1CCCCO1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Pure form	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562. [Content Brief]

[2]. Masahiro Tomita, et al. Antibody specifically recognizing resin plasticizer compound. WO2005105846A1.

THP-PEG6-OH Related Classifications

Molarity Calculator
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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

THP-PEG6-OH42607-87-4PROTAC LinkersADC LinkerAntibody-drug conjugates linkerInhibitorinhibitorinhibit

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