2. Cell Cycle/DNA Damage PI3K/Akt/mTOR
  3. ATM/ATR
  4. WSD0628

WSD0628 is a brain penetrant and potent ATM inhibitor with profound radiosensitizing effect.

For research use only. We do not sell to patients.

WSD0628 Chemical Structure

WSD0628 Chemical Structure

CAS No. : 2765448-96-0

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WSD0628 Related Antibodies

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Description

WSD0628 is a brain penetrant and potent ATM inhibitor with profound radiosensitizing effect[1].

In Vitro

WSD0628 significantly increased the radiosensitivity of U251 cells in clonogenic survival assays (0 nM vs. 30 nM at 5Gy, p<0.01)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

WSD0628 Related Antibodies
In Vivo

WSD0628 (10 mg/kg, a single dose of 12.5 Gy combined) has profound impact on treatment efficacy in the melanoma brain metastasis M12 PDX[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

439.46

Formula

C23H23F2N5O2
CAS No.
SMILES

CN(C(N1[C@H]2C(F)(F)CN(C)CC2)=O)C3=C1C4=CC(C5=CN=C(OC)C=C5)=CC=C4N=C3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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WSD0628 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

WSD06282765448-96-0WSD 0628WSD-0628ATM/ATRAtaxia telangiectasia mutatedATM and RAD3 relatedradiosensitivityU251ATMInhibitorinhibitorinhibit

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