Angiotensin Receptor Antagonist

Angiotensin Receptor Antagonists (107):

Cat. No.	Product Name	Effect	Purity

HY-117743

Eprosartan	Antagonist	99.87%
Eprosartan (SKF-108566J free base) is a selective, competitive, nonpeptid and orally active angiotensin II receptor antagonist, used as an antihypertensive. Eprosartan binds angiotensin II receptor with IC₅₀s of 9.2 nM and 3.9 nM in rat and human adrenal cortical membranes, respectively .

HY-12403A

Talfirastide acetate	Antagonist	99.87%
Angiotensin 1-7 (Ang-(1-7)) acetate is an endogenous heptapeptide from the renin-angiotensin system (RAS) with a cardioprotective role due to its anti-inflammatory and anti-fibrotic activities in cardiac cells. Angiotensin 1-7 acetate inhibits purified canine ACE activity (IC₅₀=0.65 μM). Angiotensin 1-7 acetate acts as a local synergistic modulator of kinin-induced vasodilation by inhibiting ACE and releasing nitric oxide. Angiotensin 1-7 acetate blocks Ang II-induced smooth muscle cell proliferation and hypertrophy and shows antiangiogenic and growth-inhibitory effects on the endothelium.

HY-12765

Losartan Carboxylic Acid	Antagonist	99.35%
Losartan Carboxylic Acid (E-3174), an active carboxylic acid metabolite of Losartan, is an angiotensin II receptor type 1 (AT1) antagonist. The K_i values are 0.97, 0.57, 0.67 nM for rat AT1B/AT1A and human AT1, respectively. Losartan Carboxylic Acid blocks the angiotensin II-induced responses in vascular smoothmuscle cells (VSMC). Losartan Carboxylic Acid elevates plasma renin activities and reduces mean arterial pressure.

HY-P1415A

Norleual TFA	Antagonist	99.32%
Norleual TFA, an angiotensin (Ang) IV analog, is a hepatocyte growth factor (HGF)/c-Met inhibitor with an IC₅₀ of 3 pM. Norleual TFA is an AT4 receptor antagonist and exhibits potent antiangiogenic activities.

HY-A0250

Tasosartan	Antagonist	99.07%
Tasosartan is a long-acting angiotensin II (AngII) receptor antagonist.

HY-15834A

Eprosartan mesylate	Antagonist	99.95%
Eprosartan mesylate (SKF-108566J) is a selective, competitive, nonpeptid and orally active angiotensin II receptor antagonist, used as an antihypertensive. Eprosartan mesylate binds angiotensin II receptor with IC₅₀s of 9.2 nM and 3.9 nM in rat and human adrenal cortical membranes, respectively.

HY-19732

BIBS 39	Antagonist	99.70%
BIBS 39 is a new nonpeptide angiotensin II (AII) receptor antagonist.

HY-131276

Olmesartan lactone impurity	Antagonist	99.27%
Olmesartan lactone impurity is a cyclic ester impurity of Olmesartan. Olmesartan is an angiotensin II receptor (AT1R) antagonist and has the potential for high blood pressure study.

HY-114412A

TD-0212 TFA	Antagonist	98.44%
TD-0212 TFA is an orally active dual pharmacology angiotensin II type 1 receptor (AT₁) antagonist and neprilysin (NEP) inhibitor, with a pK_i of 8.9 for AT₁ and a pIC₅₀ of 9.2 for NEP.

HY-10259

PD 123319	Antagonist
PD 123319 (ditrifluoroacetate) is a potent, selective AT2 angiotensin II receptor antagonist with IC₅₀ of 34 nM.

HY-114412

TD-0212	Antagonist
TD-0212 (compound 35) is an orally active dual pharmacology angiotensin II type 1 receptor (AT₁) antagonist and neprilysin (NEP) inhibitor, with a pK_i of 8.9 for AT₁ and a pIC₅₀ of 9.2 for NEP.

HY-135363

Valsartan Ethyl Ester	Antagonist	99.67%
Valsartan Ethyl Ester is an impurity of Valsartan. Valsartan is an angiotensin II receptor antagonist for the treatment of high blood pressure and heart failure.

HY-131278

Olmesartan methyl ester	Antagonist
Olmesartan methyl ester is an intermediate in the synthesis of Olmesartan medoxomil. Olmesartan medoxomil is a potent and selective angiotensin AT1 receptor antagonist with IC₅₀ of 66.2 μM.

HY-102093

ZD 7155(hydrochloride)	Antagonist	99.88%
ZD 7155 hydrochloride is an angiotensin II receptor type 1 (AT1 receptor) antagonist.

HY-B0205R

Candesartan (Standard)	Antagonist	98.00%
Candesartan (Standard) is the analytical standard of Candesartan. This product is intended for research and analytical applications. Candesartan (CV 11974) is an orally active angiotensin II AT1-Receptor blocker and PPAR-γ agonist. Candesartan has potent and long-lasting antihypertensive effects. Candesartan can be used for the research of hypertension, chronic heart failure (CHF) and Traumatic brain injury (TBI).

HY-131277

Dehydro Olmesartan	Antagonist	99.43%
Dehydro Olmesartan is a derivative of Olmesartan. Olmesartan is an angiotensin II receptor (AT1R) antagonist and has the potential for high blood pressure study.

HY-17458

Azilsartan medoxomil monopotassium	Antagonist	98.00%
Azilsartan medoxomil monopotassium is an orally administered angiotensin II receptor type 1 antagonist with IC50 of 0.

HY-100292

SL910102	Antagonist
SL910102 is a nonpeptide angiotensin AT₁ receptor antagonist.

HY-145552

Azilsartan mepixetil	Antagonist	98.08%
Azilsartan mepixetil is the antagonist of angiotensin II receptor. Azilsartan mepixetil has stronger and longer blood pressure effect, more abvious and longer lasting heart rate lowering effect and high safety. Azilsartan mepixetil achieves ideal protective effect for heart and kidney functions. Azilsartan mepixetil has the potential for the research of hypertension, chronic heart failure and diabetic nephropathy (extracted from patent CN107400122A).

HY-145553

Azilsartan mopivabil	Antagonist	99.56%
Azilsartan mopivabil is the potent antagonist of angiotensin II receptor.

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