Olmesartan lactone impurity

Cat. No.: HY-131276 Purity: 99.27%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Olmesartan lactone impurity is a cyclic ester impurity of Olmesartan. Olmesartan is an angiotensin II receptor (AT1R) antagonist and has the potential for high blood pressure study.

For research use only. We do not sell to patients.

Olmesartan lactone impurity Chemical Structure

CAS No. : 849206-43-5

Size	Price	Stock	Quantity
5 mg	USD 40	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 70	In-stock	Estimated Time of Arrival: December 31
50 mg		Get quote
100 mg		Get quote

or Bulk Inquiry

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Olmesartan lactone impurity:

Olmesartan lactone impurity (Standard) Get quote

Featured Recommendations

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

View All Angiotensin Receptor Isoform Specific Products:

View All Isoforms

AT1 Receptor AT2 Receptor

Biological Activity
Purity & Documentation
References
Customer Review

Description

Olmesartan lactone impurity is a cyclic ester impurity of Olmesartan. Olmesartan is an angiotensin II receptor (AT1R) antagonist and has the potential for high blood pressure study^[1]^[2].

IC₅₀ & Target

AT1 Receptor

Molecular Weight

428.49

Formula

C₂₄H₂₄N₆O₂

CAS No.

849206-43-5

Appearance

Solid

Color

White to off-white

SMILES

O=C1OC(C)(C)C2=C1N(CC3=CC=C(C4=CC=CC=C4C5=NNN=N5)C=C3)C(CCC)=N2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 125 mg/mL (291.72 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.3338 mL	11.6689 mL	23.3378 mL
5 mM	0.4668 mL	2.3338 mL	4.6676 mL
10 mM	0.2334 mL	1.1669 mL	2.3338 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.27%

Select Batch:

Data Sheet (277 KB) SDS (393 KB)

COA (257 KB) HNMR (258 KB) LCMS (88 KB)

Handling Instructions (2659 KB)

References

[1]. Yanagihara H, et al. Effects of telmisartan and olmesartan on insulin sensitivity and renal function in spontaneously hypertensive rats fed a high fat diet. J Pharmacol Sci. 2016 Jul;131(3):190-7. [Content Brief]

[2]. Tanno T, et al. Olmesartan Inhibits Cardiac Hypertrophy in Mice Overexpressing Renin Independently of Blood Pressure: Its Beneficial Effects on ACE2/Ang(1-7)/Mas Axis and NADPH Oxidase Expression. J Cardiovasc Pharmacol. 2016 Jun;67(6):503-9. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.3338 mL	11.6689 mL	23.3378 mL	58.3444 mL
	5 mM	0.4668 mL	2.3338 mL	4.6676 mL	11.6689 mL
	10 mM	0.2334 mL	1.1669 mL	2.3338 mL	5.8344 mL
	15 mM	0.1556 mL	0.7779 mL	1.5559 mL	3.8896 mL
	20 mM	0.1167 mL	0.5834 mL	1.1669 mL	2.9172 mL
	25 mM	0.0934 mL	0.4668 mL	0.9335 mL	2.3338 mL
	30 mM	0.0778 mL	0.3890 mL	0.7779 mL	1.9448 mL
	40 mM	0.0583 mL	0.2917 mL	0.5834 mL	1.4586 mL
	50 mM	0.0467 mL	0.2334 mL	0.4668 mL	1.1669 mL
	60 mM	0.0389 mL	0.1945 mL	0.3890 mL	0.9724 mL
	80 mM	0.0292 mL	0.1459 mL	0.2917 mL	0.7293 mL
	100 mM	0.0233 mL	0.1167 mL	0.2334 mL	0.5834 mL