TD-0212

Cat. No.: HY-114412: FAQs
Data Sheet Handling Instructions

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TD-0212 (compound 35) is an orally active dual pharmacology angiotensin II type 1 receptor (AT₁) antagonist and neprilysin (NEP) inhibitor, with a pK_i of 8.9 for AT₁ and a pIC₅₀ of 9.2 for NEP.

At equivalent molar concentrations, both the salt and free forms of a compound exhibit comparable biological activity. Nevertheless, the salt form (TD-0212 TFA) usually boasts enhanced water solubility and stability.

For research use only. We do not sell to patients.

TD-0212 Chemical Structure

CAS No. : 1073549-10-6

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Other Forms of TD-0212:

TD-0212 TFA Get quote

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Biological Activity
Purity & Documentation
References
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Description	TD-0212 (compound 35) is an orally active dual pharmacology angiotensin II type 1 receptor (AT₁) antagonist and neprilysin (NEP) inhibitor, with a pK_i of 8.9 for AT₁ and a pIC₅₀ of 9.2 for NEP^[1].
IC₅₀ & Target	pKi: 8.9 (AT₁) pIC50: 9.2 (NEP)^[1].
In Vitro	TD-0212 (compound 35) provides the enhanced activity of dual AT1/NEP inhibition with a potentially lower risk of angioedema relative to dual ACE/NEP inhibition^[1]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. TD-0212 Related Antibodies
In Vivo	TD-0212 (compound 35) produces blood pressure reductions similar to omapatrilat and combinations of AT1 receptor antagonists and NEP inhibitors in models of renin-dependent and –independent hypertension^[1]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight	527.65
Formula	C₂₈H₃₄FN₃O₄S
CAS No.	1073549-10-6
SMILES	OC(C1=CC=CC=C1C2=CC=C(CN3C(CNC([C@H](CC(C)C)S)=O)=C(CC)N=C3OCC)C(F)=C2)=O
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation	Data Sheet (271 KB) Handling Instructions (2659 KB)
References	[1]. McKinnell RM, et al. Discovery of TD-0212, an Orally Active Dual Pharmacology AT1 Antagonist and Neprilysin Inhibitor (ARNI). ACS Med Chem Lett. 2018 Dec 3;10(1):86-91. [Content Brief]

TD-0212 Related Classifications

Inflammation/Immunology Endocrinology

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TD-02121073549-10-6TD0212TD 0212Angiotensin ReceptorNeprilysinNeutral endopeptidaseNEPCluster of differentiation 10CD10ACEAngioedemahypertensionInhibitorinhibitorinhibit

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