2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. DGK

DGK

Diacylglycerol kinase;

DGK (Diacylglycerol Kinase) modulates the balance between DAG and phosphatidic acid (PA). DGK phorylates DAG to generate PA. DGK has ten mammalian DGK subtypes (α-κ) with subtype-specific tissue distribution, and they can be classified into 5 types. Among them, DGKα and DGKζ specifically regulate the pool of DAG that is generated as a second messenger after stimulation of the T cell receptor. Whereas, DGKζ is the dominant isoform in T cells. Dysregulation of certain DGK isoforms leads to DAG-activation of PKC, attenuation of insulin signaling, and dysregulation of glucose metabolism. DGK plays a role in many physiological events, including cell proliferation and migration, glucose intake, immunity and neuronal network construction[1][2][3].

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-153343
    BAY 2965501
    		Inhibitor 99.43%
    BAY 2965501 is a potent and selective diacylglycerol kinase zeta (DGKζ) inhibitor. BAY 2965501 induces pERK activation. BAY 2965501 can be used for the research of cancer.
    BAY 2965501
  • HY-149874
    BMS-502
    		Inhibitor 99.57%
    BMS-502 (Compound 22) is a potent dual inhibitor of diacylglycerol kinase (DGK) α and ζ with IC50 of 4.6 nM and 2.1 nM. BMS-502 enhanced T cell immune responses in mice. BMS-502 can be used in tumor immunity related research.
    BMS-502
  • HY-153343A
    (S)-BAY 2965501
    		Inhibitor 99.88%
    (S)-BAY 2965501 is the left-handed isomer of BAY 2965501 (HY-153343). BAY 2965501 is a potent and selective diacylglycerol kinase zeta (DGKζ) inhibitor. BAY 2965501 induces pERK activation. BAY 2965501 can be used for the research of cancer.
    (S)-BAY 2965501
  • HY-135898
    DGK-IN-1
    		Inhibitor 98.23%
    DGK-IN-1 is a T cell activator extracted from patent WO2020006018A1, example 25. DGK-IN-1 can be used for tumor immunity.
    DGK-IN-1
  • HY-121638A
    (5Z,2E)-CU-3
    		Inhibitor
    (5Z,2E)-CU-3 is a potent and selective inhibitor against the α-isozyme of DGK with an IC50 value of 0.6 μM, competitively inhibits the affinity of DGKα for ATP with a Km value of 0.48 mM. (5Z,2E)-CU-3 targets the catalytic region, but not the regulatory region of DGKα. (5Z,2E)-CU-3 has antitumoral and proimmunogenic effects, enhances the apoptosis of cancer cells and the activation of T cells.
    (5Z,2E)-CU-3
  • HY-169318
    DGKζ-IN-7
    		Inhibitor
    DGKζ-IN-7 (compound 97) is an oral active DGKζ inhibitor with the IC50 of 33.4 nM. DGKζ-IN-6 inhibits the secretion of IL-2 and can be used for study of cancer and autoimmune diseases.
    DGKζ-IN-7
  • HY-159649
    BMS-986408
    		Inhibitor
    BMS-986408
  • HY-169317
    DGKζ-IN-6
    		Inhibitor
    DGKζ-IN-6 (compound 40) is an oral active DGKζ inhibitor with the IC50 of 45.5 nM. DGKζ-IN-6 inhibits the secretion of IL-2 and can be used for study of cancer and autoimmune diseases.
    DGKζ-IN-6
  • HY-149665
    BMS-684
    		Inhibitor 99.76%
    BMS-684 is a selective DGKα inhibitor with an IC50 of 15 nM. BMS-684 inhibits DGKα kinase activity with >100-fold selectivity over the related DGK type I family members DGKβ and DGKγ. BMS-684 does not inhibit any of the other seven DGK isozymes.
    BMS-684
  • HY-156569
    DGKα-IN-2
    		Inhibitor 98.83%
    DGKα-IN-2 (example 48) is a DGKα inhibitor with the IC50 of 0.9 nM, extracted from patent WO2021105115. DGKα-IN-2 significantly enhances the anti-tumor effect of anti-PD-1 by increasing the proliferation and function of T cells. DGKα-IN-2 has the potential for cancer and immunology study.
    DGKα-IN-2
  • HY-149667
    BMS-332
    		Inhibitor 99.05%
    BMS-332 is adualDGKα/ζlipid kinase inhibitor, with theIC50of 0.005 (DGKα) and 0.001 μM (DGKζ).
    BMS-332
  • HY-100960
    Dioctanoylglycol
    		Inhibitor ≥98.0%
    Dioctanoylglycol (Ethylene glycol dicaprylate), a diacylglycerol analog, is a diacylglycerol kinase (DGK) inhibitor (Ki of 58 μM).
    Dioctanoylglycol
  • HY-156567
    AMB639752
    		Inhibitor 99.04%
    AMB639752 is a potent DGKα inhibitor. AMB639752 restores restimulation induced cell death (RICD) in SAP deficient lymphocytes by inhibiting DGKα in intact cells. AMB639752 can be used for X-linked lymphoproliferative disease 1(XLP-1) research.
    AMB639752
  • HY-156574
    DGKζ-IN-4
    		Inhibitor 99.52%
    DGKζ-IN-4 is a DGK-zeta inhibitor. DGKζ-IN-4 can be used as an active component of pharmaceutical compositions. DGKζ-IN-4 is used to treat cancers associated with immune cell activation or cancers resistant to anti-PD-1 antibody/anti-PD-11 antibody treatment.
    DGKζ-IN-4
  • HY-149666
    BMS-496
    		Inhibitor
    BMS-496 is adualDGKα/ζlipid kinase inhibitor, with theIC50of 0.09 (DGKα) and 0.006 μM (DGKζ).
    BMS-496
  • HY-122949
    Momordicine I
    Momordicine I, a triterpenoid compound extracted from momordica charantia L. Momordicine I alleviates isoproterenol-induced cardiomyocyte hypertrophy through suppression of PLA2G6 and DGK-ζ.
    Momordicine I
  • HY-121638
    CU-3
    		Inhibitor
    CU-3 is the racemate of (5Z,2E)-CU-3. (5Z,2E)-CU-3 is a potent and selective inhibitor against the α-isozyme of DGK with an IC50 value of 0.6 μM, competitively inhibits the affinity of DGKα for ATP with a Km value of 0.48 mM. (5Z,2E)-CU-3 targets the catalytic region, but not the regulatory region of DGKα. (5Z,2E)-CU-3 has antitumoral and proimmunogenic effects, enhances the apoptosis of cancer cells and the activation of T cells.
    CU-3
  • HY-153793
    DGKζ-IN-1
    		Inhibitor
    DGKζ-IN-1 (compound 9) is an inhibitor of DGKζ. DGKζ-IN-1 can be used for research in cancer related to immunocyte activation or cancer resistant to anti-PD-1 antibody/anti-PD-L1 antibody.
    DGKζ-IN-1
  • HY-156578
    DGKα-IN-8
    		Inhibitor
    DGKα-IN-8 (Example 51) is a DGKα inhibitor (IC50=22.491 nM; EC50=0.256 nM). DGKα-IN-8 can be used to study cancer, including solid tumors, and viral infections, such as HIV or hepatitis B virus infection.
    DGKα-IN-8
  • HY-156571
    DGKα-IN-4
    		Inhibitor
    DGKα-IN-4 (example 432) is a DGKα inhibitor with the IC50 of 0.1 nM, extracted from patent WO2021105117. DGKα-IN-2 significantly enhances the anti-tumor effect of anti-PD-1 by increasing the proliferation and function of T cells. DGKα-IN-3 has the potential for cancer and immunology study.
    DGKα-IN-4
Cat. No. Product Name / Synonyms Application Reactivity