2. Metabolic Enzyme/Protease
  3. DGK
  4. BAY 2965501

BAY 2965501 is a potent and selective diacylglycerol kinase zeta (DGKζ) inhibitor. BAY 2965501 induces pERK activation. BAY 2965501 can be used for the research of cancer.

For research use only. We do not sell to patients.

BAY 2965501 Chemical Structure

BAY 2965501 Chemical Structure

CAS No. : 2732902-08-6

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of BAY 2965501:

BAY 2965501 Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE BAY 2965501

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

BAY 2965501 is a potent and selective diacylglycerol kinase zeta (DGKζ) inhibitor. BAY 2965501 induces pERK activation. BAY 2965501 can be used for the research of cancer[1].

IC50 & Target

DGKζ[1]
In Vitro

BAY 2965501 increases natural killer cell- and T-cell-mediated tumor cell killing, and enhances IL2-induced natural killer cell activation[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

BAY 2965501 Related Antibodies
In Vivo

BAY-2965501 inhibits tumor growth inhibition in an F9 testicular teratoma model, and the combination of BAY-2965501 with immune checkpoint blockade results in additive or synergistic effects[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
Molecular Weight

414.45

Formula

C20H19FN4O3S
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

NC([C@@H](C)N(C1=CC=C(C=C1)F)C2=NC(N)=C(C(C3=CC=C(C=C3)OC)=O)S2)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (241.28 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4128 mL 12.0642 mL 24.1284 mL
5 mM 0.4826 mL 2.4128 mL 4.8257 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.4128 mL 12.0642 mL 24.1284 mL 60.3209 mL
5 mM 0.4826 mL 2.4128 mL 4.8257 mL 12.0642 mL
10 mM 0.2413 mL 1.2064 mL 2.4128 mL 6.0321 mL
15 mM 0.1609 mL 0.8043 mL 1.6086 mL 4.0214 mL
20 mM 0.1206 mL 0.6032 mL 1.2064 mL 3.0160 mL
25 mM 0.0965 mL 0.4826 mL 0.9651 mL 2.4128 mL
30 mM 0.0804 mL 0.4021 mL 0.8043 mL 2.0107 mL
40 mM 0.0603 mL 0.3016 mL 0.6032 mL 1.5080 mL
50 mM 0.0483 mL 0.2413 mL 0.4826 mL 1.2064 mL
60 mM 0.0402 mL 0.2011 mL 0.4021 mL 1.0053 mL
80 mM 0.0302 mL 0.1508 mL 0.3016 mL 0.7540 mL
100 mM 0.0241 mL 0.1206 mL 0.2413 mL 0.6032 mL
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BAY 2965501 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BAY 29655012732902-08-6BAY2965501BAY-2965501DGKDiacylglycerol kinase;Inhibitorinhibitorinhibit

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