2. Signaling Pathways
  3. Immunology/Inflammation
    Metabolic Enzyme/Protease
    NF-κB
  4. Reactive Oxygen Species

Reactive Oxygen Species

Reactive Oxygen Species

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Reactive oxygen species (ROS), such as superoxide anion (O2-), hydrogen peroxide (H2O2), and hydroxyl radical (HO•), consist of radical and non-radical oxygen species formed by the partial reduction of oxygen. Cellular ROS are generated endogenously during mitochondrial oxidative metabolism as well as in cellular response to xenobiotics, cytokines, and bacterial invasion.

ROS also activates MAPK pathways by the direct inhibition of MAPK phosphatases. Through PTEN, the PI3K pathway is subject to reversible redox regulation by ROS generated by growth factor stimulation. The activation of autophagy may be a cellular defense mechanism in response to ROS.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-146762
    MAO-B-IN-7
    		Inhibitor
    MAO-B-IN-7 is a potent and blood-brain barrier permeable MAO-B and AChE inhibitor with IC50s of 41 nM, 87 nM and 0.3 μM for human AChE, electric eel AChE and MAO-B, respectively. MAO-B-IN-7 can effectively alleviate oxidative stress and neuroinflammatory damage.
    MAO-B-IN-7
  • HY-B2130R
    Uric acid (Standard)
    Uric acid (Standard) is the analytical standard of Uric acid. This product is intended for research and analytical applications. Uric acid, scavenger of oxygen radical, is a very important antioxidant that help maintains the stability of blood pressure and antioxidant stress. Uric acid can remove reactive oxygen species (ROS) such as singlet oxygen and peroxynitrite, inhibiting lipid peroxidation.
    Uric acid (Standard)
  • HY-146194
    NHEJ inhibitor-1
    		Activator
    NHEJ inhibitor-1 (Compound C2) is a trifunctional Pt(II) complex, alleviates the  non-homologous end connection (NHEJ)/homologous recombination (HR)-related double strand breaks (DSBs) repairs to evade Cisplatin-resistance in non-small cell lung cancer (NSCLC). NHEJ inhibitor-1 inhibits the damage repair proteins Ku70 and Rad51 to make tumors re-sensitive to Cisplatin。NHEJ inhibitor-1 also induces ROS generation and MMP deduction.
    NHEJ inhibitor-1
  • HY-157440
    AChE/Aβ-IN-3
    		Inhibitor
    AChE/Aβ-IN-3 (compound AM5) is a dual inhibitor of AChE and Amyloid-β aggregation with IC50<.sub> values of 1.29 and 4.93 μM, respectively. AChE/Aβ-IN-3 has antioxidant properties that scavenge ROS and restore their normal levels. AChE/Aβ-IN-3 can be used in the study of neurological diseases, such as Alzheimer's disease.
    AChE/Aβ-IN-3
  • HY-158108
    anti-TNBC agent-6
    		Inducer
    anti-TNBC agent-6 (compound pt-3) is a potent anti-TNBC agent. anti-TNBC agent-6 shows cytotoxic activity. anti-TNBC agent-6 induces autophagy and ferroptosis. anti-TNBC agent-6 enhances intracellular ROS accumulatio. anti-TNBC agent-6 shows anti tumor activity and has the potential for the research of breast cancer.
    anti-TNBC agent-6
  • HY-146172
    Antioxidant agent-3
    		Activator
    Antioxidant agent-3 (Compound 14q), an potent antioxidant, displays potent DPPH radicals scavenging activity and ABTS+ scavenging activity with IC50s of 26.58 and 30.31 μM, respectively. Antioxidant agent-3 (Compound 14q) increases reactive oxygen species (ROS), superoxide dismutase (SOD) and glutathione (GSH), and reduced lactate dehydrogenase (LDH) in H2O2-treated HepG2 cells.
    Antioxidant agent-3
  • HY-P4280
    Arg-Tyr
    		Inhibitor
    Arg-Tyr is a dipeptide which has strong hydroxyl-radical and hydrogen-peroxide scavenging activity.
    Arg-Tyr
  • HY-N0271R
    Echinocystic acid (Standard)
    Echinocystic acid (Standard) is the analytical standard of Echinocystic acid. This product is intended for research and analytical applications. Echinocystic acid is a natural pentacyclic triterpene with potent antioxidant, anti-inflammatory and analgesic activities.
    Echinocystic acid (Standard)
  • HY-146421
    Anti-inflammatory agent 21
    		Inducer
    Anti-inflammatory agent 21 (compound 9o) is an orally active and low cytotoxic anti-inflammatory agent, with an IC50 value of 0.76 μM for NO. Anti-inflammatory agent 21 acts via accumulation ROS and blocks the NF-κB/MAPK signaling pathway. Anti-inflammatory agent 21 can ameliorate cartilage destruction and inflammatory cell infiltration in arthritis rats model.
    Anti-inflammatory agent 21
  • HY-113149
    Argininosuccinic acid
    		Inducer
    Argininosuccinic acid participates in the fourth step of the urea cycle, with being cleaved to arginine and fumaric acid by argininosuccinic acid lyase (ASL). Argininosuccinic acid reduces reduced glutathione (GSH) level, and increases the production of reactive oxygen species in cerebral cortex and striatum. Argininosuccinic acid causes lipid peroxidation and protein oxidation, and induces oxidative stress in the developing rat brain.
    Argininosuccinic acid
  • HY-120349
    LL-Z1640-4
    		Inhibitor
    LL-Z1640-4 is a potent p38/JNK signaling inhibitor. LL-Z1640-4 significantly diminishes p38 and JNK activation in HCC cells transfected with MLK4 siRNA. LL-Z1640-4 markedly attenuates ROS production induced by MLK4 knockdown. LL-Z1640-4 significantly reduces the apoptotic cells in HCC cells transfected with siMLK4.
    LL-Z1640-4
  • HY-123894
    Pelargonidin 3,5-diglucoside chloride
    		Inhibitor
    Pelargonidin 3,5-diglucoside (chloride) is a natural pigment abundantly present in red fruits and vegetables. Pelargonidin 3,5-diglucoside (chloride) acts as a scavenger for reactive oxygen species and reactive nitrogen species . Pelargonidin 3,5-diglucoside (chloride) demonstrates inhibitory effects on enzymes involved in the production of ROS, RNS, and pro-inflammatory cytokines.
    Pelargonidin 3,5-diglucoside chloride
  • HY-112328
    Fascaplysin
    		Inducer
    Fascaplysin is an antimicrobial and cytotoxic red pigment, that can come from the marine sponge (Fascaplysinopsis sp.). Fascaplysin has been synthesized in seven steps from indole (65% yield). Fascaplysin can induces apoptosis and autophagy in human leukemia HL-60 cells. Fascaplysin shows anti-tumor activity.
    Fascaplysin
  • HY-N8413
    Chlojaponilactone B
    		Inhibitor
    Chlojaponilactone B is a lindenane-type sesquiterpenoid with anti-inflammatory properties. Chlojaponilactone B suppresses inflammatory responses by inhibiting TLR4 and subsequently decreasing reactive oxygen species (ROS) generation, downregulating the NF-κB, thus reducing the expression of the pro-inflammatory cytokines iNOS, NO, COX-2, IL-6 and TNF-α.
    Chlojaponilactone B
  • HY-B0849S
    Azoxystrobin-d4
    		Activator
    Azoxystrobin-d4 is deuterium labeled Azoxystrobin. Azoxystrobin is a broad-spectrum β-methoxyacrylate fungicide. Azoxystrobin inhibits mitochondrial respiration by binding to the Qo site of the cytochrome bc1 complex and inhibiting electron transfer. Azoxystrobin induces the production of reactive oxygen species (ROS) and induces cell apoptosis.
    Azoxystrobin-d<sub>4</sub>
  • HY-161460
    Ferroptosis-IN-7
    		Inhibitor
    Ferroptosis-IN-7(Compound 26) is a ferroptosis inhibitor which can restore cell viability, reduce iron accumulation and scavenge reactive oxygen species. Ferroptosis-IN-7 can be used for vascular diseases research.
    Ferroptosis-IN-7
  • HY-N0796R
    Procyanidin B2 (Standard)
    Procyanidin B2 (Standard) is the analytical standard of Procyanidin B2. This product is intended for research and analytical applications. Procyanidin B2 is a natural flavonoid, with anti-cancer, antioxidant activities.
    Procyanidin B2 (Standard)
  • HY-B0166S5
    L-Ascorbic acid-13C-4
    L-Ascorbic acid-13C-4 is the 13C labeled L-Ascorbic acid. L-Ascorbic acid (L-Ascorbate), an electron donor, is an endogenous antioxidant agent. L-Ascorbic acid inhibits selectively Cav3.2 channels with an IC50 of 6.5 μM. L-Ascorbic acid is also a collag
    L-Ascorbic acid-<sup>13</sup>C-4
  • HY-P1184
    HNGF6A
    		Inhibitor
    HNGF6A is a humanin analogue. HNGF6A increases glucose-stimulated insulin secretion and glucose metabolism, and has the potential for diabetes research. HNGF6A inhibits of ROS production during oxidative stress. HNGF6A can prevent endothelial dysfunction and atherosclerosis in vivo.
    HNGF6A
  • HY-N12653
    Exserohilone
    		Inhibitor
    Exserohilone ((-)-Exserohilone) is a thiodiketopiperazine derivative that exhibits the inhibition of TNF-α-induced ROS generation and MMP-1 secretion. Exserohilone increases the procollagen type I α1 secretion in human dermal fibroblasts.
    Exserohilone
Cat. No. Product Name / Synonyms Application Reactivity