2. Natural Products
  3. Marine natural products
  4. Sponge

Sponge

Sponge (40):

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-13605
    Cytarabine 147-94-4 99.98%
    Cytarabine, a nucleoside analog, causes S phase cell cycle arrest and inhibits DNA polymerase. Cytarabine inhibits DNA synthesis with an IC50 of 16 nM. Cytarabine has antiviral effects against HSV. Cytarabine shows anti-orthopoxvirus activity.
    Cytarabine
  • HY-16929
    Latrunculin A 76343-93-6 ≥98.0%
    Latrunculin A (LAT-A), found in the red sea sponge Latrunculia magnifica, is a G-actin polymerization inhibitor. Latrunculin A binds to actin monomers and inhibits polymerization of actin with Kds of 0.1, 0.4, 4.7 μM and 0.19 μM for ATP-actin, ADP-Pi-actin, ADP-actin and G-actin, respectively. Latrunculin A has effective anti-metastatic properties for cancer research. Latrunculin A blocks cell migration.
    Latrunculin A
  • HY-P0027
    Jasplakinolide 102396-24-7 99.50%
    Jasplakinolide is a potent actin polymerization inducer and stabilizes pre-existing actin filaments. Jasplakinolide binds to F-actin competitively with phalloidin with a Kd of 15 nM. Jasplakinolide, a naturally occurring cyclic peptide from the marine sponge, has both fungicidal and anti-cancer activity.
    Jasplakinolide
  • HY-101848
    Latrunculin B 76343-94-7 ≥98.0%
    Latrunculin B, an antimicrobial marine alkaloid, is an actin polymerization inhibitor. Latrunculin B regulates pulmonary vein electrophysiological characteristics and attenuates stretch-induced arrhythmogenesis. Antifungal and antiprotozoal activity.
    Latrunculin B
  • HY-N4225
    Aaptamine 85547-22-4 99.71%
    Aaptamine, a spongean alkaloid isolated from a sea sponge Aaptos aaptos, is a competitive antagonist of α-adrenoceptor and activates the p21 promoter in a p53-independent manner.
    Aaptamine
  • HY-W052289
    Methyl 6-bromo-1H-indole-3-carboxylate 868656-97-7
    Methyl 6-bromo-1H-indole-3-carboxylate is a marine-derived natural product with antitumor activity. Methyl 6-bromo-1H-indole-3-carboxylate showed growth inhibition against Staphylococcus epidermidis, exhibiting weak or moderate minimum inhibitory concentrations (MICs).
    Methyl 6-bromo-1H-indole-3-carboxylate
  • HY-111266
    Halenaquinone 86690-14-4
    Halenaquinone is a phosphatidylinositol 3-kinase inhibitor and can be isolated from the marine sponge Petrosia alfiani. Halenaquinone inhibits RANKL-induced osteoclastogenesis, and induces cell apoptosis in PC12 cells.
    Halenaquinone
  • HY-117500
    Aplysamine-1 159026-30-9
    Aplysamine-1 acts as an antagonist for the histamine H3 receptor.
    Aplysamine-1
  • HY-N2150
    Psammaplin A 110659-91-1
    Psammaplin A, a marine metabolite, is a potent inhibitor of HDAC and DNA methyltransferases. Psammaplin A ia a highly potent and selective DAC1 inhibitor with an IC50 of 0.9 nM. Psammaplin A possess the antimicrobial effect on the Gram-positive bacteria and inhibits DNA synthesis and DNA gyrase activity. Antitumor Activity.
    Psammaplin A
  • HY-117025A
    Manzamine A hydrochloride 104264-80-4 99.66%
    Manzamine A hydrochloride, an orally active beta-carboline alkaloid, inhibits specifically GSK-3β and CDK-5 with IC50s of 10.2 μM and 1.5 μM, respectively. Manzamine A hydrochloride targets vacuolar ATPases and inhibits autophagy in pancreatic cancer cells. Manzamine A hydrochloride has antimalarial and anticancer activities. Manzamine A hydrochloride also shows potent activity against HSV-1.
    Manzamine A hydrochloride
  • HY-117371
    Hemiasterlin 157207-90-4 99.77%
    Hemiasterlin ((-)-Hemiasterlin) is an antimitotic marine natural product with potent anticancer effcts. Hemiasterlin can be used as a cytotoxic payload (ADC Cytotoxin) in antibody-drug conjugates (ADCs).
    Hemiasterlin
  • HY-119500
    Ilimaquinone 71678-03-0 ≥99.0%
    Ilimaquinone, a marine sponge metabolite, displays anticancer activity via GADD153-mediated pathway. Ilimaquinone can induce vesiculation of the Golgi apparatus. Ilimaquinone exerts anti-HIV, anti-microbial, anti-inflammatory, and effects.
    Ilimaquinone
  • HY-19827
    Aeroplysinin 1 28656-91-9
    Aeroplysinin 1 ((+)-Aeroplysinin-1), a secondary metabolite isolated from marine sponges, shows potent antibiotic effects on Gram-positive bacteria and exerts antiviral activity against HIV-1 (IC50=14.6 μM). Aeroplysinin 1 has anti-inflammatory, anti-angiogenic and anti-tumor activities. Aeroplysinin 1 induces apoptosis in endothelial cells.
    Aeroplysinin 1
  • HY-111009
    Swinholide A 95927-67-6 98.3%
    Swinholide A is the actin-binding marine polyketide and dimerizes actin with the Kd of ~ 50 nM. Swinholide A is a microfilament disrupting marine toxin that stabilizes actin dimers and severs actin filaments. Swinholide A disrupts the actin cytoskeleton of cells.Antifungal activity.
    Swinholide A
  • HY-N6794
    10Z-Hymenialdisine 82005-12-7
    10Z-Hymenialdisine ((Z)-Hymenialdisine) is a natural bioactive pyrrole alkaloid. 10Z-Hymenialdisine is a pan kinase inhibitor, and has anticancer activities.
    10Z-Hymenialdisine
  • HY-117025
    Manzamine A 104196-68-1
    Manzamine A, an orally active beta-carboline alkaloid, inhibits specifically GSK-3β and CDK-5 with IC50s of 10.2 μM and 1.5 μM, respectively. Manzamine A targets vacuolar ATPases and inhibits autophagy in pancreatic cancer cells. Manzamine A has antimalarial and anticancer activities. Manzamine A also shows potent activity against HSV-1.
    Manzamine A
  • HY-W035305
    Methyl 2-(6-bromo-1H-indol-3-yl)acetate 152213-63-3
    Methyl 2-(6-bromo-1H-indol-3-yl)acetate is a natural product derived from marine sources, specifically isolated from Pseudosuberites hyalinus.
    Methyl 2-(6-bromo-1H-indol-3-yl)acetate
  • HY-N10660
    Dictyostatin 156312-07-1
    Dictyostatin ((-)-Dictyostatin; Dictyostatin 1) is a potent microtubule stabilizing agent. Dictyostatin also is a anti-cancer agent. Dictyostatin shows antiproliferative activity. Dictyostatin has the potential for the research of tauopathies.
    Dictyostatin
  • HY-118328
    Hymenidin 107019-95-4
    Hymenidin is a natural antagonist of serotonergic receptor and inhibitor of voltage-gated potassium channels. Hymenidin also induces cancer cell apoptosis.
    Hymenidin
  • HY-112328
    Fascaplysin 114719-57-2
    Fascaplysin is an antimicrobial and cytotoxic red pigment, that can come from the marine sponge (Fascaplysinopsis sp.). Fascaplysin has been synthesized in seven steps from indole (65% yield). Fascaplysin can induces apoptosis and autophagy in human leukemia HL-60 cells. Fascaplysin shows anti-tumor activity.
    Fascaplysin