2. MAPK/ERK Pathway Apoptosis Metabolic Enzyme/Protease Immunology/Inflammation NF-κB
  3. p38 MAPK JNK Apoptosis Reactive Oxygen Species
  4. LL-Z1640-4

LL-Z1640-4 is a potent p38/JNK signaling inhibitor. LL-Z1640-4 significantly diminishes p38 and JNK activation in HCC cells transfected with MLK4 siRNA. LL-Z1640-4 markedly attenuates ROS production induced by MLK4 knockdown. LL-Z1640-4 significantly reduces the apoptotic cells in HCC cells transfected with siMLK4.

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LL-Z1640-4 Chemical Structure

LL-Z1640-4 Chemical Structure

CAS No. : 66018-41-5

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Based on 1 publication(s) in Google Scholar

LL-Z1640-4 Related Antibodies

Top Publications Citing Use of Products

View All p38 MAPK Isoform Specific Products:

View All Isoforms
p38 MAPK p38α p38β MAPK13 p38δ p38γ

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View All Isoforms
JNK1 JNK2 JNK3 JNK

  • Biological Activity

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Description

LL-Z1640-4 is a potent p38/JNK signaling inhibitor. LL-Z1640-4 significantly diminishes p38 and JNK activation in HCC cells transfected with MLK4 siRNA. LL-Z1640-4 markedly attenuates ROS production induced by MLK4 knockdown. LL-Z1640-4 significantly reduces the apoptotic cells in HCC cells transfected with siMLK4[1][2].

Cellular Effect
Cell Line Type Value Description References
HeLa IC50
> 50 μM
Compound: 2
Inhibition of NFkappa p65 isolated from nuclear extract of human HeLa cells by ELISA
Inhibition of NFkappa p65 isolated from nuclear extract of human HeLa cells by ELISA
[PMID: 21513293]
HT-29 IC50
> 25 μM
Compound: 2
Cytotoxicity against human HT-29 cells after 72 hrs by MTS assay
Cytotoxicity against human HT-29 cells after 72 hrs by MTS assay
[PMID: 21513293]
MCF7 IC50
> 100 μM
Compound: 2
Cytotoxicity against human MCF7 cells after 72 hrs by MTS assay
Cytotoxicity against human MCF7 cells after 72 hrs by MTS assay
[PMID: 21513293]
MDA-MB-435 IC50
> 25 μM
Compound: 2
Cytotoxicity against human MDA-MB-435 cells after 72 hrs by MTS assay
Cytotoxicity against human MDA-MB-435 cells after 72 hrs by MTS assay
[PMID: 21513293]
NCI-H460 IC50
> 100 μM
Compound: 2
Cytotoxicity against human H460 cells after 72 hrs by MTS assay
Cytotoxicity against human H460 cells after 72 hrs by MTS assay
[PMID: 21513293]
SF-268 IC50
> 100 μM
Compound: 2
Cytotoxicity against human SF268 cells after 72 hrs by MTS assay
Cytotoxicity against human SF268 cells after 72 hrs by MTS assay
[PMID: 21513293]
In Vitro

LL-Z1640-4 markedly restores the number of cells in migration and invasion decreased by siMLK4, and significantly up-regulates expression of MMP2 and Vimentin[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

LL-Z1640-4 Related Antibodies
Molecular Weight

364.39

Formula

C19H24O7
CAS No.
SMILES

O=C1OC(C/C=C/C(C(C(C/C=C/C2=C1C(O)=CC(OC)=C2)O)O)O)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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LL-Z1640-4 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

LL-Z1640-466018-41-5p38 MAPKJNKApoptosisReactive Oxygen Speciesc-Jun N-terminal kinaseHCC cellssiMLK4MLK4HepG2BEL-7404 cellsMMP2Hepatocellular carcinomaInhibitorinhibitorinhibit

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