2. Immunology/Inflammation NF-κB Metabolic Enzyme/Protease
  3. NO Synthase NF-κB Reactive Oxygen Species
  4. Anti-inflammatory agent 21

Anti-inflammatory agent 21 (compound 9o) is an orally active and low cytotoxic anti-inflammatory agent, with an IC50 value of 0.76 μM for NO. Anti-inflammatory agent 21 acts via accumulation ROS and blocks the NF-κB/MAPK signaling pathway. Anti-inflammatory agent 21 can ameliorate cartilage destruction and inflammatory cell infiltration in arthritis rats model.

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Anti-inflammatory agent 21 Chemical Structure

Anti-inflammatory agent 21 Chemical Structure

CAS No. : 2408836-40-6

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Anti-inflammatory agent 21 Related Antibodies

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Description

Anti-inflammatory agent 21 (compound 9o) is an orally active and low cytotoxic anti-inflammatory agent, with an IC50 value of 0.76 μM for NO. Anti-inflammatory agent 21 acts via accumulation ROS and blocks the NF-κB/MAPK signaling pathway. Anti-inflammatory agent 21 can ameliorate cartilage destruction and inflammatory cell infiltration in arthritis rats model[1].

IC50 & Target

IC50: 0.76 μM (NO)[1]
Cellular Effect
Cell Line Type Value Description References
RAW264.7 IC50
> 40 μM
Compound: 9o
Cytotoxicity against mouse RAW264.7 cells assessed as reduction in cell viability incubated for 24 hrs in presence of LPS by MTT assay
Cytotoxicity against mouse RAW264.7 cells assessed as reduction in cell viability incubated for 24 hrs in presence of LPS by MTT assay
[PMID: 32823004]
RAW264.7 IC50
> 40 μM
Compound: 9o
Cytotoxicity against mouse RAW264.7 cells assessed as reduction in cell viability incubated for 24 hrs in absence of LPS by MTT assay
Cytotoxicity against mouse RAW264.7 cells assessed as reduction in cell viability incubated for 24 hrs in absence of LPS by MTT assay
[PMID: 32823004]
RAW264.7 IC50
0.76 μM
Compound: 9o
Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production preincubated for 1 hr followed by LPS stimulation and measured after 24 hrs by Griess reagent-based assay
Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production preincubated for 1 hr followed by LPS stimulation and measured after 24 hrs by Griess reagent-based assay
[PMID: 32823004]
Molecular Weight

424.42

Formula

C24H21FO6
CAS No.
SMILES

COC1=CC2=C(C(OC)=C1)C(OC2C(C3=CC=C(C=C3)OCC4=CC=C(C=C4)F)O)=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Anti-inflammatory agent 21 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-inflammatory agent 212408836-40-6NO SynthaseNF-κBReactive Oxygen SpeciesNitric oxide synthasesNOSNuclear factor-κBNuclear factor-kappaBAnti-inflammatoryOrally activeArthritiscartilageInflammatory cell infiltrationSD ratInhibitorinhibitorinhibit

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