2. Autophagy Apoptosis Metabolic Enzyme/Protease Immunology/Inflammation NF-κB
  3. Autophagy Ferroptosis Reactive Oxygen Species
  4. anti-TNBC agent-6

anti-TNBC agent-6 (compound pt-3) is a potent anti-TNBC agent. anti-TNBC agent-6 shows cytotoxic activity. anti-TNBC agent-6 induces autophagy and ferroptosis. anti-TNBC agent-6 enhances intracellular ROS accumulatio. anti-TNBC agent-6 shows anti tumor activity and has the potential for the research of breast cancer.

For research use only. We do not sell to patients.

anti-TNBC agent-6 Chemical Structure

anti-TNBC agent-6 Chemical Structure

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anti-TNBC agent-6 Related Antibodies

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Description

anti-TNBC agent-6 (compound pt-3) is a potent anti-TNBC agent. anti-TNBC agent-6 shows cytotoxic activity. anti-TNBC agent-6 induces autophagy and ferroptosis. anti-TNBC agent-6 enhances intracellular ROS accumulatio. anti-TNBC agent-6 shows anti tumor activity and has the potential for the research of breast cancer[1].

In Vitro

anti-TNBC agent-6 (compound pt-3) (48 h) shows cytotoxic for MDA-MB-231, MCF-7, B16-F10, SK-OV-3, WI-38 cells[1].
anti-TNBC agent-6 (2 µM; 0, 12, 24, 36, 48 h) induce autophagy by increases the expression of Beclin-1, LC3-II in a time dependent manner in MDA-MB-231 cells[1].
anti-TNBC agent-6 (2 µM; 0, 12, 24, 36, 48 h) induces ferroptosis by decreases the expression of GPX4 in a time dependent manner[1].
anti-TNBC agent-6 (1, 2 µM) increases MDA content in MDA-MB-231 cells in a dose dependent manner[1].
anti-TNBC agent-6 (2 µM) enhances intracellular ROS accumulation and increases the labile iron pool (LIP) within cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

anti-TNBC agent-6 Related Antibodies

Cell Cytotoxicity Assay[1]

Cell Line: A549, A549/CDDP cells
Concentration: 0-28 µM
Incubation Time: 48 h
Result: Showed cytotoxic activity with IC50s of 2.84, 4.12 µM for A549, A549/CDDP cells, respectively.

Western Blot Analysis[1]

Cell Line: MDA-MB-231 cells
Concentration: 2 µM
Incubation Time: 0, 12, 24, 36, 48 h
Result: Increased the expression of Beclin-1, LC3-II in a time dependent manner.
In Vivo

anti-TNBC agent-6 (10 mg/kg; i.p.; on days 0, 3, 6, 9, 12, 15, and 18) shows anti tumor activity in MDA-MB-231 xenograft model[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 25 g, 5 weeks, female KM mice (MDA-MB-231 xenograft model)[1]
Dosage: 10 mg/kg
Administration: I.p.; on days 0, 3, 6, 9, 12, 15, and 18
Result: Significantly inhibited tumor growth compared to the vehicle controls, elicited an inhibition rates of tumor growth (IRT) as high as 65.3%.
Molecular Weight

768.51

Formula

C28H18F6N3O2PPt-
SMILES

[F-][P+5]([F-])([F-])([F-])([F-])[F-].C12=C(C=C3C4=[N](C=CC3=C2)[Pt]5([N]6=CC=CC7=C6C8=C(C=C7)C=CC=[N]85)C9=CC=CC=C49)OCO1.[+]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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anti-TNBC agent-6 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

anti-TNBC agent-6AutophagyFerroptosisReactive Oxygen SpeciesautophagyferroptosisROSbreast cancerMDA-MB-231 cellsMDA contentBeclin-1LC3-IIInhibitorinhibitorinhibit

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