2. Metabolic Enzyme/Protease NF-κB Immunology/Inflammation
  3. Endogenous Metabolite Reactive Oxygen Species
  4. Argininosuccinic acid

Argininosuccinic acid participates in the fourth step of the urea cycle, with being cleaved to arginine and fumaric acid by argininosuccinic acid lyase (ASL). Argininosuccinic acid reduces reduced glutathione (GSH) level, and increases the production of reactive oxygen species in cerebral cortex and striatum. Argininosuccinic acid causes lipid peroxidation and protein oxidation, and induces oxidative stress in the developing rat brain.

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Argininosuccinic acid Chemical Structure

Argininosuccinic acid Chemical Structure

CAS No. : 2387-71-5

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Argininosuccinic acid Related Antibodies

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Description

Argininosuccinic acid participates in the fourth step of the urea cycle, with being cleaved to arginine and fumaric acid by argininosuccinic acid lyase (ASL). Argininosuccinic acid reduces reduced glutathione (GSH) level, and increases the production of reactive oxygen species in cerebral cortex and striatum. Argininosuccinic acid causes lipid peroxidation and protein oxidation, and induces oxidative stress in the developing rat brain[1][2].

In Vitro

Argininosuccinic acid (250-1000 μM; 1 h) significantly increases MDA levels and decreases sulfhydryl and carbonyl formation (protein oxidation) in cerebral cortex[1].
Argininosuccinic acid (250-1000 μM; 1 h) decreases reduced glutathione (GSH) concentrations in cerebral cortex of 30-day-old rats[1].
Argininosuccinic acid (500 μM; 1 h) increases 2’,7’-dichlorofluorescein (DCFH) oxidation in cerebral cortex of 30-day-old rats[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Argininosuccinic acid Related Antibodies
In Vivo

Argininosuccinic acid (2 μM for 2 μL; ICV; single dose) significantly induces oxidative stress in 30-day-old rats[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 30-day-old rats with two small holes drilled in the skull[1]
Dosage: 2 μL of a 1.0 M concentration (2 μmol in 2 μL)
Administration: Injection; euthanized 2 h after treatment
Result: Significantly induced lipid oxidation (MDA levels) and protein oxidation (carbonyl formation), increased ROS and RNS generation (DCFH oxidation).
Significantly decreased GSH concentrations.
Molecular Weight

290.27

Formula

C10H18N4O6
CAS No.
SMILES

OC([C@@H](N)CCCNC(N[C@H](C(O)=O)CC(O)=O)=N)=O
Structure Classification
Initial Source
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Argininosuccinic acid Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Argininosuccinic acid2387-71-5Endogenous MetaboliteReactive Oxygen SpeciesInhibitorinhibitorinhibit

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