2. Apoptosis NF-κB Metabolic Enzyme/Protease Immunology/Inflammation
  3. Ferroptosis Reactive Oxygen Species
  4. Ferroptosis-IN-7

Ferroptosis-IN-7(Compound 26) is a ferroptosis inhibitor which can restore cell viability, reduce iron accumulation and scavenge reactive oxygen species. Ferroptosis-IN-7 can be used for vascular diseases research.

For research use only. We do not sell to patients.

Ferroptosis-IN-7 Chemical Structure

Ferroptosis-IN-7 Chemical Structure

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 457 In-stock
Solution
10 mM * 1 mL in DMSO USD 481 In-stock
Solid
5 mg USD 390 In-stock
10 mg USD 625 In-stock
25 mg USD 1250 In-stock
50 mg   Get quote  
100 mg   Get quote  

Get it by May 20 for select sizes. Order within 16 hrs 53 mins.

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Customer Review

Based on 1 publication(s) in Google Scholar

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  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Ferroptosis-IN-7(Compound 26) is a ferroptosis inhibitor which can restore cell viability, reduce iron accumulation and scavenge reactive oxygen species. Ferroptosis-IN-7 can be used for vascular diseases research[1].

In Vitro

Ferroptosis-IN-7 (10 μM, 24 h) rescues cell viability from 10 μM Erastin (HY-15763) and reduces iron and ROS accumulation, maintain mitochondrial membrane potential, increase GSH levels, decrease LPO and MDA content, and upregulate GPX4 expression[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

560.75

Formula

C32H40N4O3S
Appearance

Solid

Color

White to off-white

SMILES

O=C(N1CCN(CC2=CC=C(S(C)(=O)=O)C=C2)CC1)C3=CC=C(NC4CCCCC4)C(NCC5=CC=CC=C5)=C3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (178.33 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.7833 mL 8.9166 mL 17.8333 mL
5 mM 0.3567 mL 1.7833 mL 3.5667 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    90% Corn Oil

    Solubility: ≥ 5 mg/mL (8.92 mM); Clear solution

    This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO +
% 
+
%
Tween-80 +
%
Saline
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
The co-solvents required include: DMSO, PEG300/PEG400, Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.7833 mL 8.9166 mL 17.8333 mL 44.5831 mL
5 mM 0.3567 mL 1.7833 mL 3.5667 mL 8.9166 mL
10 mM 0.1783 mL 0.8917 mL 1.7833 mL 4.4583 mL
15 mM 0.1189 mL 0.5944 mL 1.1889 mL 2.9722 mL
20 mM 0.0892 mL 0.4458 mL 0.8917 mL 2.2292 mL
25 mM 0.0713 mL 0.3567 mL 0.7133 mL 1.7833 mL
30 mM 0.0594 mL 0.2972 mL 0.5944 mL 1.4861 mL
40 mM 0.0446 mL 0.2229 mL 0.4458 mL 1.1146 mL
50 mM 0.0357 mL 0.1783 mL 0.3567 mL 0.8917 mL
60 mM 0.0297 mL 0.1486 mL 0.2972 mL 0.7431 mL
80 mM 0.0223 mL 0.1115 mL 0.2229 mL 0.5573 mL
100 mM 0.0178 mL 0.0892 mL 0.1783 mL 0.4458 mL
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Ferroptosis-IN-7 Related Classifications

Keywords:

Ferroptosis-IN-7FerroptosisReactive Oxygen Speciesiron accumulationROSmitochondrial membrane potentialGSHLPOMDAGPX4vascular diseaseInhibitorinhibitorinhibit

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