BI 703704

Cat. No.: HY-117962A: FAQs
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BI 703704 is a potent soluble guanylate cyclase (sGC) activator. BI 703704 inhibits the progression of diabetic nephropathy in the ZSF1 rat.

For research use only. We do not sell to patients.

BI 703704 Chemical Structure

CAS No. : 2740807-77-4

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Description

BI 703704 is a potent soluble guanylate cyclase (sGC) activator. BI 703704 inhibits the progression of diabetic nephropathy in the ZSF1 rat^[1].

In Vivo

BI 703704 (0.3-10 mg/kg; food intake; daily for 15 weeks) results in dose-dependent decreases in urinary protein excretion (UPE), and a dose-dependent increase in renal cGMP content^[1].
BI 703704 is effective in elevating renal cGMP levels in a dose-dependent manner and in slowing the progression of diabetic nephropathy in an oxidative stress milieu^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Fifty-eight male ZSF1 rats (12-13 weeks)^[1]
Dosage:	0.3, 1, 3, or 10 mg/kg
Administration:	Food intake; daily for 15 weeks
Result:	Resulted in dose-dependent decreases in urinary protein excretion (UPE), and a dose-dependent increase in renal cGMP content.

Molecular Weight

559.72

Formula

C₃₂H₃₇N₃O₄S

CAS No.

2740807-77-4

Appearance

Solid

Color

White to off-white

SMILES

CC1=CC(C2=CSC(N3C[C@H](CC4)[C@@H](C(O)=O)[C@H]4C3)=N2)=C(OCC5=CC=C(C(N6CCCCC6)=O)C=C5C)C=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Boustany-Kari CM, et al. A Soluble Guanylate Cyclase Activator Inhibits the Progression of Diabetic Nephropathy in the ZSF1 Rat. J Pharmacol Exp Ther. 2016 Mar;356(3):712-9. [Content Brief]

BI 703704 Related Classifications

Metabolic Disease

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BI 7037042740807-77-4BI703704BI-703704Guanylate CyclasediabeticnephropathyZSF1ratcGMPtype2diabetesoxidativestressmilieuInhibitorinhibitorinhibit

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