2. Signaling Pathways
  3. Membrane Transporter/Ion Channel
  4. ATP-binding cassette (ABC) transporters

ATP-binding cassette (ABC) transporters

ATP-binding cassette transporters

ATP-binding cassette (ABC) transporters are a large group of membrane proteins, comprising 49 transporters that are further subdivided into seven subfamilies, ABC ­A to ­G, based on sequence similarities, that have two nucleotide-binding domains (NBDs) and two transmembrane binding domains (TMDs). ATP-binding cassette (ABC) transporters couple transport of a substrate against a chemical gradient and energized directly by the hydrolysis of ATP. ATP-binding cassette transporters transport a wide variety of substrates, including inorganic and organic small molecules like metal ions, sugars, amino acids, nucleotides, and vitamins, as well as larger organic compounds such as peptides, proteins, oligonucleotides, cellular metabolites, and drugs. ATP-binding cassette (ABC) transporters are involved in many important physiological processes like nutrient uptake, cellular detoxification, lipid homeostasis, signal transduction, viral defense, and antigen presentation. ATP-binding cassette (ABC) transporters play an important role in a number of diseases, including Stargardt disease, Alzheimer's disease, immune deficiency, and cystic fibrosis[1][2].

ATP-binding cassette (ABC) transporters Related Products (6):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-W010649
    Isoxazole
    		Inhibitor 99.98%
    Isoxazole is a member of the five-membered heterocycle drug scaffold. Isoxazole has been used as a BET bromodomain inhibitor and can improve β-cell function in a diabetic mouse model. Isoxazole and its derivatives exhibit broad biological activities (such as antimicrobial, antibacterial, antifungal, antiviral, anticancer, anti-inflammatory, immunomodulatory, analgesic, anti-tuberculosis, and anti-diabetic effects). For example, the bicyclic Isoxazole can act as an HSP90 inhibitor, and the tricyclic Isoxazole is promising as a selective multidrug resistance protein (MRP1) inhibitor​.
    Isoxazole
  • HY-W585842
    Estradiol 3-glucuronide
    		98.00%
    Estradiol 3-glucuronide is an immunogen with antigenic properties. Estradiol 3-glucuronide induced antiserum in the rabbit possesses high afinity and specifcity to Estradiol 3-glucuronide. Estradiol 3-glucuronide is promising for research of radioimmunoassay.
    Estradiol 3-glucuronide
  • HY-W010649R
    Isoxazole (Standard)
    		Inhibitor
    Amfenac (Sodium Hydrate) (Standard) is the analytical standard of Amfenac (Sodium Hydrate). This product is intended for research and analytical applications. Amfenac Sodium Hydrate is a COX-2 inhibitor.
    Isoxazole (Standard)
  • HY-P990325
    Anti-ABCB5 Antibody
    Anti-ABCB5 Antibody is a CHO-expressed human antibody that targets ABCB5. The Anti-ABCB5 Antibody has a huIgG2 heavy chain and a huκ light chain, with a predicted molecular weight (MW) of 145 kDa. The isotype control for the Anti-ABCB5 Antibody can refer to Human IgG1 kappa, Isotype Control (HY-P99001).
    Anti-ABCB5 Antibody
  • HY-120432
    CaMdr1p-IN-1
    		Inhibitor
    CaMdr1p-IN-1 (Compound A) is an inhibitor for the major facilitator superfamily transporter CaMdr1p. CaMdr1p-IN-1 exhibits chemosensitizing efficacy. CaMdr1p-IN-1 synergizes with Fluconazole (HY-B0101), that inhibits CaMdr1p overexpressing Candida albicans with MIC of 10 μM.
    CaMdr1p-IN-1
  • HY-137307
    Cholest-5-ene-3ß,22(S)-diol
    		Inducer
    Cholest-5-ene-3ß,22(S)-diol ((22S)-Hydroxycholesterol) is an orally active oxysterol with no significant cytotoxic, oxidative, or inflammatory effects on human prokaryotic leukemia cells. Cholest-5-ene-3ß,22(S)-diol inhibits weight gain and increased serum triacylglycerol (TAG) levels in rat models.
    Cholest-5-ene-3ß,22(S)-diol