2. Antibody-drug Conjugate/ADC Related
  3. ADC Linker
  4. Fmoc-Asp-NH2

Fmoc-Asp-NH2 is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

For research use only. We do not sell to patients.

Fmoc-Asp-NH2 Chemical Structure

Fmoc-Asp-NH2 Chemical Structure

CAS No. : 200335-40-6

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10 mM * 1 mL in DMSO
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Based on 1 publication(s) in Google Scholar

Fmoc-Asp-NH2 Related Antibodies

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Description

Fmoc-Asp-NH2 is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

IC50 & Target

Cleavable Linker

 

In Vitro

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Fmoc-Asp-NH2 Related Antibodies
Molecular Weight

354.36

Formula

C19H18N2O5
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(O)C[C@H](NC(OCC1C2=C(C3=C1C=CC=C3)C=CC=C2)=O)C(N)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (705.50 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.8220 mL 14.1099 mL 28.2199 mL
5 mM 0.5644 mL 2.8220 mL 5.6440 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 98.49%

SDS (393 KB)

COA (252 KB) HNMR (120 KB) RP-HPLC (189 KB)

Handling Instructions (2659 KB)

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.8220 mL 14.1099 mL 28.2199 mL 70.5497 mL
5 mM 0.5644 mL 2.8220 mL 5.6440 mL 14.1099 mL
10 mM 0.2822 mL 1.4110 mL 2.8220 mL 7.0550 mL
15 mM 0.1881 mL 0.9407 mL 1.8813 mL 4.7033 mL
20 mM 0.1411 mL 0.7055 mL 1.4110 mL 3.5275 mL
25 mM 0.1129 mL 0.5644 mL 1.1288 mL 2.8220 mL
30 mM 0.0941 mL 0.4703 mL 0.9407 mL 2.3517 mL
40 mM 0.0705 mL 0.3527 mL 0.7055 mL 1.7637 mL
50 mM 0.0564 mL 0.2822 mL 0.5644 mL 1.4110 mL
60 mM 0.0470 mL 0.2352 mL 0.4703 mL 1.1758 mL
80 mM 0.0353 mL 0.1764 mL 0.3527 mL 0.8819 mL
100 mM 0.0282 mL 0.1411 mL 0.2822 mL 0.7055 mL
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Fmoc-Asp-NH2 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Fmoc-Asp-NH2200335-40-6ADC LinkerAntibody-drug conjugates linkerADClinkercleavableInhibitorinhibitorinhibit

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