SNX16 - sorting nexin 16 Gene

Homo sapiens

Gene ID: 64089 | Gene type: protein coding

About SNX16

Cytogenetic location: 8q21.13 Genomic coordinates (GRCh38): 8:81,799,583-81,842,185 (from NCBI)

This gene has 11 transcripts (splice variants), 237 orthologues and 1 paralogue. Ubiquitous expression in testis (RPKM 6.1), esophagus (RPKM 5.5) and 24 other tissues.

Summary

This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. The protein encoded by this gene associates with late endosome membranes as is involved in tubule formation, Cholesterol transport, and transport of tetraspanin CD81. The encoded protein also inhibits cell migration and tumorigenesis. [provided by RefSeq, Jan 2017]

SNX16 Products(4)

mRNA	Protein	Name
NM_001348189.2	NP_001335118.1	sorting nexin-16 isoform c
NM_022133.4	NP_071416.2	sorting nexin-16 isoform a
NM_152836.3	NP_690049.1	sorting nexin-16 isoform a
NM_152837.3	NP_690050.1	sorting nexin-16 isoform b

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	12813048	GOA
enables phosphatidylinositol binding	IDA IDA: Inferred from direct assay	12813048	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in early endosome to late endosome transport	IMP IMP: Inferred from mutant phenotype	12813048	GOA
involved in endosome to lysosome transport	IMP IMP: Inferred from mutant phenotype	12813048	GOA
involved in protein targeting to lysosome	IMP IMP: Inferred from mutant phenotype	12813048	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in early endosome	IDA IDA: Inferred from direct assay	12813048	GOA
located in endosome membrane	IDA IDA: Inferred from direct assay	12813048	GOA
located in late endosome	IDA IDA: Inferred from direct assay	12813048	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SNX16 Protein Structure

0
100
200
300
344 a.a.

Protein Preferred Names

Protein Names

sorting nexin-16

Related Diseases

Diseases

Alias

Spinocerebellar Ataxia 15

SCA15	Spinocerebellar Ataxia Type 15
Spinocerebellar Ataxia Type 16	Sca16
Spinocerebellar Ataxia Type 15/16	Spinocerebellar Ataxia 16, Formerly
Sca16, Formerly	Spinocerebellar Ataxia 16
Sca15/16	Ataxia, Spinocerebellar, Type 15

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13529	SNX16 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	SNX16	MGD	MGI:1921968
Rattus norvegicus	SNX16	RGD	RGD:620295
Bos taurus	SNX16	VGNC	VGNC:35096
Canis familiaris	SNX16	VGNC	VGNC:46625
Macaca mulatta	SNX16	VGNC	VGNC:77710
Felis catus	SNX16	VGNC	VGNC:65546

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