ARHGAP18 - Rho GTPase activating protein 18 Gene

Homo sapiens

Also known as SENEX; MacGAP; bA307O14.2

Gene ID: 93663 | Gene type: protein coding

About ARHGAP18

Cytogenetic location: 6q22.33 Genomic coordinates (GRCh38): 6:129,576,132-129,710,177 (from NCBI)

This gene has 3 transcripts (splice variants), 212 orthologues and 3 paralogues. Ubiquitous expression in adrenal (RPKM 22.0), lung (RPKM 16.4) and 25 other tissues.

Summary

ARHGAP18 belongs to a family of Rho (see MIM 165390) GTPase-activating proteins that modulate cell signaling (Potkin et al., 2009 [PubMed 19065146]).[supplied by OMIM, Apr 2010]

ARHGAP18 Products(1)

mRNA	Protein	Name
NM_033515.3	NP_277050.2	rho GTPase-activating protein 18

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables GTPase activator activity	IMP IMP: Inferred from mutant phenotype	21865595	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in regulation of actin cytoskeleton organization	IMP IMP: Inferred from mutant phenotype	21865595	GOA
involved in regulation of actin filament polymerization	IMP IMP: Inferred from mutant phenotype	21865595	GOA
involved in regulation of cell motility	IMP IMP: Inferred from mutant phenotype	21865595	GOA
involved in regulation of cell shape	IMP IMP: Inferred from mutant phenotype	21865595	GOA
involved in regulation of small GTPase mediated signal transduction	IMP IMP: Inferred from mutant phenotype	21865595	GOA
involved in small GTPase-mediated signal transduction	IMP IMP: Inferred from mutant phenotype	21865595	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IMP IMP: Inferred from mutant phenotype	21865595	GOA
located in cytoplasmic microtubule	IDA IDA: Inferred from direct assay	28251925	GOA
located in ruffle	IDA IDA: Inferred from direct assay	28251925	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ARHGAP18 Protein Structure

RhoGAP

0
200
400
600
663 a.a.

Protein Preferred Names

Protein Names

rho GTPase-activating protein 18

rho-type GTPase-activating protein 18

Related Diseases

Diseases

Alias

Hemoglobin E Disease

Hemoglobin E

Hb-E Disease

Aortic Aneurysm, Familial Thoracic 1

Thoracic Aortic Aneurysm	Annuloaortic Ectasia
Familial Thoracic Aortic Aneurysm And Aortic Dissection	Familial Aortic Dissection
Familial Taad	Familial Thoracic Aortic Aneurysm
Congenital Aneurysm Of Ascending Aorta	Familial Aortic Aneurysm
Familial Thoracic Aortic Aneurysm And Dissection	Aortic Aneurysm, Thoracic
AAT1	Faa1
Aortic Dissection, Familial	Aortic Aneurysm, Familial Thoracic
Aneurysm, Thoracic Aortic	Faa
Ftaad	Taa
Taad	Cystic Medial Necrosis Of Aorta
Familial Non-Syndromic Thoracic Aortic Aneurysm And Aortic Dissection	Aortic Aneurysm Thoracic
Familial Aortic Aneurysms	Aneurysm, Aortic, Thoracic, Familial, Type 1
Aneurysm Of Thoracic Aorta	Intrathoracic Aneurysm
Thoracic Aorta Aneurysm	Thoracic Aortic Aneurysm Without Rupture
Thoracic Aneurysm	Thorax Arterial Aneurysm
Thoracic Artery Aneurysm	Thoracic Arterial Aneurysm
Thorax Aneurysm	Thorax Aortic Aneurysm
Dissection Of Thoracic Aorta

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00918	ARHGAP18 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	ARHGAP18	VGNC	VGNC:38049
Macaca mulatta	ARHGAP18	VGNC	VGNC:69875
Felis catus	ARHGAP18	VGNC	VGNC:59878
Bos taurus	ARHGAP18	VGNC	VGNC:26078
Rattus norvegicus	ARHGAP18	RGD	RGD:1305053
Mus musculus	ARHGAP18	MGD	MGI:1921160

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