2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. iGluR
  4. LBG20304

LBG20304 (compound 2s) is a ligand for the homologous GluK5 receptor (IC50: 432 nM), more than 40-fold selective over the homologous GluK1-3 isoforms. Low doses of LBG20304 (<10 μM) have no agonist or antagonist functional response at heterologous GluK2/5 receptors, and at high doses (>10 μM), it exhibits low agonist activity in neuronal slices (rat).

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LBG20304 Chemical Structure

LBG20304 Chemical Structure

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LBG20304 Related Antibodies

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Description

LBG20304 (compound 2s) is a ligand for the homologous GluK5 receptor (IC50: 432 nM), more than 40-fold selective over the homologous GluK1-3 isoforms. Low doses of LBG20304 (<10 μM) have no agonist or antagonist functional response at heterologous GluK2/5 receptors, and at high doses (>10 μM), it exhibits low agonist activity in neuronal slices (rat)[1].

IC50 & Target

IC50: 432 nM (GluK5)[1]
Molecular Weight

382.37

Formula

C19H18N4O5
SMILES

O=C([C@H]1NC[C@H](N2N=NC=C2C3=CC=C4C=C(O)C=CC4=C3)[C@@H]1CC(O)=O)O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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LBG20304 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

LBG20304LBG 20304LBG-20304iGluRIonotropic glutamate receptorsInhibitorinhibitorinhibit

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