Blogs (3)

CL097 is a TLR7/8 Agonist, Induces Pro-Inflammatory Cytokines

2022-01-28

CL097 is a TLR7/8 agonist. CL097 induces pro-nflammatory cytokines. CL097 induces NADPH oxidase priming and efficient diabetogenic cytotoxic T lymphocyte (CTL) function in NOD mice.
S18-000003 is a Selective and Orally Active RORγt Inhibitor

2019-06-22

S18-000003 is a potent, selective and orally active inhibitor of retinoic acid receptor-related orphan receptor-gamma-t (RORγt). S18-000003 ameliorates psoriasis-like lesions in vivo. S18-000003 can be used for the research of skin inflammatory diseases.
TAK-828F is a Potent, Selective and Orally Active RORγt Inverse Agonist

2019-04-25

TAK-828F is a potent, selective and orally active retinoic acid receptor-related orphan receptor γt (RORγt) inverse agonist. TAK-828F inhibits IL-17A cytokine expression and reduces symptoms of autoimmune encephalomyelitis mice.

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