2. Academic Validation
  3. A self-assembled peroxidase from 5'-GMP and heme

A self-assembled peroxidase from 5'-GMP and heme

  • Chem Commun (Camb). 2018 Feb 14;54(13):1587-1590. doi: 10.1039/c7cc09900b.
Deiaa M Harraz 1,  Jeffery T Davis 1
Affiliations

Affiliation

  • 1 Department of Chemistry & Biochemistry, University of Maryland College Park, MD 20742, USA. jdavis@umd.edu.
PMID: 29368765 DOI: 10.1039/c7cc09900b
Abstract

Guanosine 5'-monophosphate (5'-GMP) and Fe(iii)-heme form a supramolecular catalyst with peroxidase activity. Catalysis, which depends on self-assembly of 5'-GMP into a G-quadruplex that binds hemin, can be modulated by nucleotide concentration, temperature and the identity of the nucleotide's sugar.

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