2. Metabolic Enzyme/Protease Neuronal Signaling Membrane Transporter/Ion Channel
  3. Endogenous Metabolite iGluR
  4. 5'-Guanylic acid

5'-Guanylic acid  (Synonyms: 5'-GMP; 5'-guanosine monophosphate)

Cat. No.: HY-N5134 Purity: 99.69%
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COA
Handling Instructions Technical Support

5'-Guanylic acid is a purine nucleotide that participates in physiological processes such as energy metabolism, signal transduction, and gene expression regulation. 5'-Guanylic acid regulates the expression of genes related to fatty acid metabolism. 5'-Guanylic acid is the weak agonist for ionotropic glutamate receptors (iGluR), reduces the activity of the glutamatergic system and exhibits neuroprotective effect. 5'-Guanylic acid also causes neuronal cell death at high concentrations.

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5'-Guanylic acid Chemical Structure

5'-Guanylic acid Chemical Structure

CAS No. : 85-32-5

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Based on 1 publication(s) in Google Scholar

Other Forms of 5'-Guanylic acid:

5'-Guanylic acid Related Antibodies

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1 Publications Citing Use of MCE 5'-Guanylic acid

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Description

5'-Guanylic acid is a purine nucleotide that participates in physiological processes such as energy metabolism, signal transduction, and gene expression regulation. 5'-Guanylic acid regulates the expression of genes related to fatty acid metabolism. 5'-Guanylic acid is the weak agonist for ionotropic glutamate receptors (iGluR), reduces the activity of the glutamatergic system and exhibits neuroprotective effect. 5'-Guanylic acid also causes neuronal cell death at high concentrations[1][2][3].

IC50 & Target

Human Endogenous Metabolite

 

In Vitro

5'-Guanylic acid (50-500 μM, 48 h) regulates the expression of genes involved in fatty acid metabolism, affects fatty acid composition in Oncorhynchus mykiss hepatocytes, and regulates fatty acid metabolism[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

5'-Guanylic acid Related Antibodies

Real Time qPCR[1]

Cell Line: Oncorhynchus mykiss hepatocytes
Concentration: 50-500 μM
Incubation Time: 12-48 h
Result: Upregulated the expressions of Δ5 fads2, elovl2, elovl5 and srebp-1.
Downregulated the expression of pparα.
In Vivo

5'-Guanylic acid (10-150 mg/kg, ip, single dose) exhibits anti-anxiety effect in Wistar rats models[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Wistar rats models[2].
Dosage: 10-150 mg/kg
Administration: ip, single dose
Result: Increased the time rats spent in the light zone in the light-dark box test.
Increased the time rats spent in the open arms in the elevated plus maze test.
Molecular Weight

363.22

Formula

C10H14N5O8P
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=P(O)(OC[C@@H]1[C@H]([C@H]([C@H](N2C=NC3=C2N=C(N)NC3=O)O1)O)O)O
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

H2O : 83.33 mg/mL (229.42 mM; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.7532 mL 13.7658 mL 27.5315 mL
5 mM 0.5506 mL 2.7532 mL 5.5063 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: 99.69%

SDS (393 KB)

COA (251 KB) RP-HPLC (260 KB) LCMS (97 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 2.7532 mL 13.7658 mL 27.5315 mL 68.8288 mL
5 mM 0.5506 mL 2.7532 mL 5.5063 mL 13.7658 mL
10 mM 0.2753 mL 1.3766 mL 2.7532 mL 6.8829 mL
15 mM 0.1835 mL 0.9177 mL 1.8354 mL 4.5886 mL
20 mM 0.1377 mL 0.6883 mL 1.3766 mL 3.4414 mL
25 mM 0.1101 mL 0.5506 mL 1.1013 mL 2.7532 mL
30 mM 0.0918 mL 0.4589 mL 0.9177 mL 2.2943 mL
40 mM 0.0688 mL 0.3441 mL 0.6883 mL 1.7207 mL
50 mM 0.0551 mL 0.2753 mL 0.5506 mL 1.3766 mL
60 mM 0.0459 mL 0.2294 mL 0.4589 mL 1.1471 mL
80 mM 0.0344 mL 0.1721 mL 0.3441 mL 0.8604 mL
100 mM 0.0275 mL 0.1377 mL 0.2753 mL 0.6883 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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5'-Guanylic acid Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

5'-Guanylic acid85-32-55'-GMP 5'-guanosine monophosphateEndogenous MetaboliteiGluRIonotropic glutamate receptorsanxietylong-chain polyunsaturated fatty acidInhibitorinhibitorinhibit

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