2. Academic Validation
  3. Escherichia coli small molecule metabolism at the host-microorganism interface

Escherichia coli small molecule metabolism at the host-microorganism interface

  • Nat Chem Biol. 2021 Oct;17(10):1016-1026. doi: 10.1038/s41589-021-00807-5.
Alexandra Gatsios 1 2,  Chung Sub Kim 1 2 3,  Jason M Crawford 4 5 6
Affiliations

Affiliations

  • 1 Department of Chemistry, Yale University, New Haven, CT, USA.
  • 2 Institute of Biomolecular Design & Discovery, Yale University, West Haven, CT, USA.
  • 3 School of Pharmacy, Sungkyunkwan University, Suwon, Republic of Korea.
  • 4 Department of Chemistry, Yale University, New Haven, CT, USA. jason.crawford@yale.edu.
  • 5 Institute of Biomolecular Design & Discovery, Yale University, West Haven, CT, USA. jason.crawford@yale.edu.
  • 6 Department of Microbial Pathogenesis, Yale University School of Medicine, New Haven, CT, USA. jason.crawford@yale.edu.
PMID: 34552219 DOI: 10.1038/s41589-021-00807-5
Abstract

Escherichia coli are a common component of the human microbiota, and isolates exhibit probiotic, commensal and pathogenic roles in the host. E. coli members often use diverse small molecule chemistry to regulate intrabacterial, intermicrobial and host-bacterial interactions. While E. coli are considered to be a well-studied model organism in biology, much of their chemical arsenal has only more recently been defined, and much remains to be explored. Here we describe chemical signaling systems in E. coli in the context of the broader field of metabolism at the host-bacteria interface and the role of this signaling in disease modulation.

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