2. Academic Validation
  3. Lactones as inhibitors of the fibrinolytic system

Lactones as inhibitors of the fibrinolytic system

  • Science. 1967 Jun 2;156(3779):1244-5. doi: 10.1126/science.156.3779.1244.
W Auerswald,  W Doleschel
PMID: 4225897 DOI: 10.1126/science.156.3779.1244
Abstract

Caprolactone, valerolactone, and butyrolactone inhibit proteolytic and fibrinolytic activities of human plasmin. In very low concentrations, they also inhibit activation of plasminogen through plasmin-streptokinase activator and human urokinase. The degree of inhibitory potency depends upon the number of carbon atoms in the lactone.

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