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AXIN2

" in MedChemExpress (MCE) Product Catalog:

By Targets:	PARP (2) Small Interfering RNA (siRNA) (1) Wnt (2) β-catenin (3)
By Research Areas:	Cancer (5) Inflammation/Immunology (1)
Oligonucleotides:	Pre-designed siRNA Sets (1) siRNAs (1)

Inhibitors & Agonists

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

MSC2504877 M2912	PARP	Cancer
MSC2504877 (M2912) is a potent and orally active tankyrase inhibitor with IC₅₀s of 0.0007, 0.0008, 0.54 µM for TNKS, TNKS2, PARP1, respectively. MSC2504877 increases the expression of AXIN2 and TNKS protein levels and decreases β-catenin levels. MSC2504877 shows anti-tumor activity .

DK419	Wnt β-catenin	Cancer
DK419 is a potent and orally active Wnt/β-catenin signaling inhibitor, with an IC₅₀ of 0.19 μM. DK419 reduces protein lelvels of Axin2, β-catenin, c-Myc, Cyclin D1 and Survivin and induces production of pAMPK .

AXIN2 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
AXIN2 Human Pre-designed siRNA Set A contains three designed siRNAs for AXIN2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

AXIN2 Human Pre-designed siRNA Set A AXIN2 Human Pre-designed siRNA Set A

TC-E 5001	PARP	Cancer
TC-E 5001 is an inhibitor of Wnt pathway that inhibits tankyrase 1/2 (TNKS1/2) via novel adenosine pocket binding, with K_ds of 79 nM and 28 nM, respectively. TC-E 5001 also inhibits *Axin2* and STF, with IC₅₀s of 0.709 μM and 0.215 μM, respectively ^[2].

Antitumor agent-171	β-catenin	Inflammation/Immunology Cancer
Antitumor agent-171 (Compound 35) is an inhibitor for β-catenin/BCL9 interaction with IC₅₀ of 1.61 μM. Antitumor agent-171 exhibits high affinity to β-catenin with K_d of 0.63 μM. Antitumor agent-171 inhibits the gene expression of axin2 with IC₅₀ of 0.84 μM. Antitumor agent-171 inhibits cell viability of HCT116 with IC₅₀ of 4.39 μM. Antitumor agent-171 activates T cells, promotes antigen presentation, and exhibits antitumor efficacy and good pharmacokinetic characteristics in mouse models .

E722-2648	β-catenin Wnt	Cancer
E722-2648 is a potent β-catenin/BCL9 complex inhibitor. E722-2648 specifically inhibits β-catenin/BCL9 complex formation and Wnt activity. E722-2648 disrupts cholesterol homeostasis via increased cholesterol esterification and lipid droplet accumulation. E722-2648 has antitumor activity .

Cat. No.	Compare	Product Name	Application	Reactivity

	Axin 2 Antibody (YA2222) Axil; AXIN like protein; AXIN2; Axis inhibition protein 2; Conductin	WB	Human, Mouse, Rat
	Axin 2 Antibody (YA2222) is a biotin-conjugated non-conjugated IgG antibody, targeting Axin 2, with a predicted molecular weight of 94 kDa (observed band size: 94 kDa). Axin 2 Antibody (YA2222) can be used for WB experiment in human, mouse, rat background.

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AXIN2 Human Pre-designed siRNA Set A		siRNAs Pre-designed siRNA Sets
AXIN2 Human Pre-designed siRNA Set A contains three designed siRNAs for AXIN2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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