DK419

Cat. No.: HY-112799 Purity: 99.88%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

DK419 is a potent and orally active Wnt/β-catenin signaling inhibitor, with an IC₅₀ of 0.19 μM. DK419 reduces protein lelvels of Axin2, β-catenin, c-Myc, Cyclin D1 and Survivin and induces production of pAMPK.

For research use only. We do not sell to patients.

DK419 Chemical Structure

CAS No. : 2102672-22-8

Size	Price	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	USD 385	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 385	In-stock	Estimated Time of Arrival: December 31
Solid
5 mg	USD 350	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 550	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 1650	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 2250	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

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This product is a controlled substance and not for sale in your territory.

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Based on 1 publication(s) in Google Scholar

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Description

IC₅₀ & Target

Wnt/β-catenin^[1]

Cellular Effect

Cell Line	Type	Value	Description	References
DLD-1	IC₅₀	0.36 μM Compound: DK419	Antiproliferative activity against human DLD1 cells after 72 hrs by colorimetric MTS assay Antiproliferative activity against human DLD1 cells after 72 hrs by colorimetric MTS assay	[PMID: 30274939]
HCT-116	IC₅₀	0.28 μM Compound: DK419	Antiproliferative activity against human HCT116 cells after 72 hrs by colorimetric MTS assay Antiproliferative activity against human HCT116 cells after 72 hrs by colorimetric MTS assay	[PMID: 30274939]
HT-29	IC₅₀	0.12 μM Compound: DK419	Antiproliferative activity against human HT-29 cells after 72 hrs by colorimetric MTS assay Antiproliferative activity against human HT-29 cells after 72 hrs by colorimetric MTS assay	[PMID: 30274939]
SW480	IC₅₀	0.33 μM Compound: DK419	Antiproliferative activity against human SW480 cells after 72 hrs by colorimetric MTS assay Antiproliferative activity against human SW480 cells after 72 hrs by colorimetric MTS assay	[PMID: 30274939]
SW948	IC₅₀	0.07 μM Compound: DK419	Antiproliferative activity against human SW948 cells after 72 hrs by colorimetric MTS assay Antiproliferative activity against human SW948 cells after 72 hrs by colorimetric MTS assay	[PMID: 30274939]

Molecular Weight

407.70

Formula

C₁₆H₈ClF₆N₃O

CAS No.

2102672-22-8

Appearance

Solid

Color

White to off-white

SMILES

O=C(C1=C2C(N=C(C(F)(F)F)N2)=CC(Cl)=C1)NC3=CC=C(C(F)(F)F)C=C3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	2 years
	-20°C	1 year

Solvent & Solubility

In Vitro:

DMSO : 83.33 mg/mL (204.39 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.4528 mL	12.2639 mL	24.5278 mL
5 mM	0.4906 mL	2.4528 mL	4.9056 mL
10 mM	0.2453 mL	1.2264 mL	2.4528 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.88%

Select Batch:

Data Sheet (273 KB) SDS (252 KB)

COA (250 KB) LCMS (264 KB)

Handling Instructions (2659 KB)

References

[1]. Wang J, et al. Identification of DK419, a potent inhibitor of Wnt/β-catenin signaling and colorectal cancer growth. Bioorg Med Chem. 2018 Nov 1;26(20):5435-5442. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.4528 mL	12.2639 mL	24.5278 mL	61.3196 mL
	5 mM	0.4906 mL	2.4528 mL	4.9056 mL	12.2639 mL
	10 mM	0.2453 mL	1.2264 mL	2.4528 mL	6.1320 mL
	15 mM	0.1635 mL	0.8176 mL	1.6352 mL	4.0880 mL
	20 mM	0.1226 mL	0.6132 mL	1.2264 mL	3.0660 mL
	25 mM	0.0981 mL	0.4906 mL	0.9811 mL	2.4528 mL
	30 mM	0.0818 mL	0.4088 mL	0.8176 mL	2.0440 mL
	40 mM	0.0613 mL	0.3066 mL	0.6132 mL	1.5330 mL
	50 mM	0.0491 mL	0.2453 mL	0.4906 mL	1.2264 mL
	60 mM	0.0409 mL	0.2044 mL	0.4088 mL	1.0220 mL
	80 mM	0.0307 mL	0.1533 mL	0.3066 mL	0.7665 mL
	100 mM	0.0245 mL	0.1226 mL	0.2453 mL	0.6132 mL

DK419 Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DK4192102672-22-8DK 419DK-419Wntβ-cateninBeta cateninInhibitorinhibitorinhibit

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DK419

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DK419 Related Antibodies

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Complete Stock Solution Preparation Table

DK419 Related Classifications

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