2. Stem Cell/Wnt
  3. Wnt β-catenin
  4. DK419

DK419 is a potent and orally active Wnt/β-catenin signaling inhibitor, with an IC50 of 0.19 μM. DK419 reduces protein lelvels of Axin2, β-catenin, c-Myc, Cyclin D1 and Survivin and induces production of pAMPK.

For research use only. We do not sell to patients.

DK419 Chemical Structure

DK419 Chemical Structure

CAS No. : 2102672-22-8

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 385 In-stock
Solution
10 mM * 1 mL in DMSO USD 385 In-stock
Solid
1 mg USD 166 In-stock
5 mg USD 350 In-stock
10 mg USD 550 In-stock
50 mg USD 1650 In-stock
100 mg USD 2250 In-stock
200 mg   Get quote  
500 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

DK419 is a potent and orally active Wnt/β-catenin signaling inhibitor, with an IC50 of 0.19 μM. DK419 reduces protein lelvels of Axin2, β-catenin, c-Myc, Cyclin D1 and Survivin and induces production of pAMPK[1].

IC50 & Target

Wnt/β-catenin[1]
Molecular Weight

407.70

Formula

C16H8ClF6N3O
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(C1=C2C(N=C(C(F)(F)F)N2)=CC(Cl)=C1)NC3=CC=C(C(F)(F)F)C=C3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

DMSO : 83.33 mg/mL (204.39 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4528 mL 12.2639 mL 24.5278 mL
5 mM 0.4906 mL 2.4528 mL 4.9056 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
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Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

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Volume (start)

V1

=
Concentration (final)

C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.4528 mL 12.2639 mL 24.5278 mL 61.3196 mL
5 mM 0.4906 mL 2.4528 mL 4.9056 mL 12.2639 mL
10 mM 0.2453 mL 1.2264 mL 2.4528 mL 6.1320 mL
15 mM 0.1635 mL 0.8176 mL 1.6352 mL 4.0880 mL
20 mM 0.1226 mL 0.6132 mL 1.2264 mL 3.0660 mL
25 mM 0.0981 mL 0.4906 mL 0.9811 mL 2.4528 mL
30 mM 0.0818 mL 0.4088 mL 0.8176 mL 2.0440 mL
40 mM 0.0613 mL 0.3066 mL 0.6132 mL 1.5330 mL
50 mM 0.0491 mL 0.2453 mL 0.4906 mL 1.2264 mL
60 mM 0.0409 mL 0.2044 mL 0.4088 mL 1.0220 mL
80 mM 0.0307 mL 0.1533 mL 0.3066 mL 0.7665 mL
100 mM 0.0245 mL 0.1226 mL 0.2453 mL 0.6132 mL
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DK419 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DK4192102672-22-8DK 419DK-419Wntβ-cateninBeta cateninInhibitorinhibitorinhibit

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