Search Result

Results for "

Caspase substrate

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Caspase (31) Angiotensin-converting Enzyme (ACE) (1) Apoptosis (1) Ceramidase (1) Cholinesterase (ChE) (1) CRISPR/Cas9 (1) Fluorescent Dye (16) Interleukin Related (1) PARP (1) Proteasome (1)
By Research Areas:	Cancer (14) Infection (1) Inflammation/Immunology (4) Metabolic Disease (1)

Inhibitors & Agonists

Fluorescent Dye

Peptides

MCE Kits

Targets Recommended: Caspase MARCKS

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P2091

Ac-YVAD-pNA	Caspase	Inflammation/Immunology
Ac-YVAD-pNA is a specific *Caspase-1* substrate. Ac-YVAD-pNA can be used to detect Caspase-1 activity. Caspase-1 is a key mediator of inflammatory processes .

HY-P2617A

Ac-WEHD-AFC TFA	Caspase	Inflammation/Immunology Cancer
Ac-WEHD-AFC TFA is a fluorogenic caspase-1 substrate. Ac-WEHD-AFC TFA can measure caspase-1 fluorogenic activity and can be used for the research of tumor and inflammation .

HY-P1169

Ac-IETD-AFC 1 Publications Verification	Caspase	Others
Ac-IETD-AFC is a fluorogenic substrate of caspase-8, caspase-3, caspase-10, and granzyme B .

HY-P3363

Z-DEVD-AMC	Caspase	Cancer
Z-DEVD-AMC is a selective caspase-3 substrate that can be measured by fluorescence spectrometry. AMC can be used as a fluorescence reference standard for AMC-based enzyme substrates including AMC-based caspase substrates .

HY-P10450

(Asp)2-Rhodamine 110 D2R; (D)2-Rhodamine 110	Caspase	Others
(Asp)2-Rhodamine 110 (D2R) is a fluorescent caspase substrate .

HY-P10083

Ac-VQVD-pNA	Fluorescent Dye	Others
Ac-VQVD-pNA is a chromogenic substrate of *caspase* 3 .

HY-P2615

Ac-VDVAD-AFC	Fluorescent Dye	Cancer
Ac-VDVAD-AFC is a caspase-specific fluorescent substrate. Ac-VDVAD-AFC can measure caspase-3-like activity and caspase-2 activity and can be used for the research of tumor and cancer .

HY-P2615A

Ac-VDVAD-AFC TFA	Fluorescent Dye	Cancer
Ac-VDVAD-AFC TFA is a caspase-specific fluorescent substrate. Ac-VDVAD-AFC TFA can measure caspase-3-like activity and caspase-2 activity and can be used for the research of tumor and cancer .

HY-P4403

Z-DEVD-R110 (Z-Asp-Glu-Val-Asp)₂-Rhodamine 110	Fluorescent Dye Apoptosis Caspase	Others
Z-DEVD-R110 ((Z-Asp-Glu-Val-Asp)₂-Rhodamine 110) is a fluorogenic caspase-3/7 substrate. Z-DEVD-R110 can be used to detect apoptosis. Z-DEVD-R110 is a rhodamine derivative with two four–amino acid (DEVD) peptides linked to the fuorophore .

HY-P2617

Ac-WEHD-AFC	Caspase	Inflammation/Immunology Cancer
Ac-WEHD-AFC is a fluorogenic caspase-1 substrate. Ac-WEHD-AFC can measure caspase-1 fluorogenic activity and can be used for the research of tumor and inflammation .

HY-P4392

Z-VAD-AMC	Caspase	Others
Z-VAD-AMC is a substrate of caspase-9 .

HY-P4401

Z-VEID-AFC	Caspase	Others
Z-VEID-AFC is a fluorescent substrate for caspase-6 .

HY-P1093

Ac-LEHD-AFC 1 Publications Verification	Caspase	Others
Ac-LEHD-AFC is a fluorescent substrate for caspase-9, can be used to assess the activity of caspase .

HY-W713878

Ac-VDVAD-pNA	Caspase	Others
Ac-VDVAD-pNA is a *caspase-2* substrate. Ac-VDVAD-pNA can be used to test the activity of caspase-2 .

HY-P10084

Ac-VAD-pNA	Caspase	Others
Ac-VAD-pNA is a *caspase-1* substrate. Ac-VAD-pNA can be used to detect caspase-1 activity .

HY-P10452

Ac-LEVDGWK(Dnp)-NH2	Caspase	Others
Ac-LEVDGWK(Dnp)-NH2 is a substrate for *Caspase-3, and can be used to detect Caspase*-3 activity .

HY-P5983

Ac-VEID-AFC	Caspase	Cancer
Ac-VEID-AFC is a *caspase-6* fluorogenic substrate, and can be used in the caspase 6 activity assay .

HY-P3475

Mca-VDQMDGW-K(Dnp)-NH2	Fluorescent Dye	Others
Mca-VDQMDGWK-(Dnp)-NH2 is a fluorogenic substrate for caspase-3 and can be used to quantify caspase-3 activity .

HY-P2614

Mca-DEVDAP-K(Dnp)-OH	Caspase	Others
Mca-DEVDAP-K(Dnp)-OH is a fluorogenic substrate for *caspase-3* .

HY-P10276

Ac-VAD-AFC	Caspase	Cancer
Ac-VAD-AFC is a fluorescent substrate for caspases and can be used to test the activity of caspases .

HY-P1006

Ac-DEVD-pNA 1 Publications Verification	Caspase	Others
Ac-DEVD-pNA is a colorimetric substrate for caspase-3 (CPP32) and related cysteine proteases.

HY-P5974

Z-YVAD-pNA Z-Tyr-Val-Ala-Asp-pNA	Caspase	Others
Z-YVAD-pNA (Z-Tyr-Val-Ala-Asp-pNA) is a *caspase-1* substrate .

HY-P2208

Z-IETD-AFC	Fluorescent Dye	Cancer
Z-IETD-AFC, a specific fluorescence substrate, can be used to determine the caspase-8 catalytic activity .

HY-P3362

Ac-IETD-AMC	Fluorescent Dye	Others
Ac-IETD-AMC is a fluorogenic caspase-8/granzyme B substrate containing the acetyl (Ac) moiety. Ac-IETD-AMC is frequently used to measure caspase-8 activity .

HY-P3476

Mca-VDQVDGW-Lys(Dnp)-NH2	CRISPR/Cas9	Cancer
Mca-VDQVDGW-Lys(Dnp)-NH2 is a fluorogenic substrate of caspase-7. Mca-VDQVDGW-K(Dnp)-NH2 can be used to quantify caspase-7 activity.

HY-P10454

(Z-IETD)2-Rh 110 (Z-Ile-Glu-Thr-Asp)2-R110	Caspase	Others
(Z-IETD)2-Rh 110 is a fluorescent substrate of *caspase-8* (λex= 488 nm, λem= 523 nm), which can be used to detect the activity of *caspase-8* and the process of apoptosis .

HY-P10236

Ac-WEHD-pNA	Caspase	Others
Ac-WEHD-pNA is a colorimetric substrate for *caspase* 1, 4, 5 and 14, which is utilized to measure the caspase activity .

HY-P4547

Ac-Trp-Glu-His-Asp-AMC AC-WEHD-AMC	Caspase	Others
Ac-Trp-Glu-His-Asp-AMC (AC-WEHD-AMC) is a potent fluorogenic substrate of caspase-1 .

HY-D1652

Ac-LEHD-AMC	Caspase	Others
Ac-LEHD-AMC is a fluorogenic substrate for *caspase-9* (Excitation: 341 nm; Emission: 441 nm). Caspase-9 can induce hydrolysis of Ac-LEHD-AMC, resulting in the release of AMC fluorophore and its fluorescence can be used to quantify caspase-9 activity .

HY-P2620

Ac-LETD-AFC	Fluorescent Dye	Metabolic Disease Cancer
Ac-LETD-AFC is a **caspase-8 fluorogenic substrate*. Ac-LETD-AFC can measure caspase*-8 fluorogenic activity and can be used for the research of cancer cell apoptosis and oxidative stress metabolism .

HY-P10322

Z-IETD-R110	Fluorescent Dye	Cancer
Z-IETD-R110 is a fluorescent substrate of *caspases. Z-IETD-R110 acts as a substrate* for *caspase-8. When caspase-8* is activated, it can recognize and cut Z-IETD-R110, releasing fluorophore, which can be detected by fluorescence microscopy. Z-IETD-R110 can be used to study oxidative stress-induced apoptosis, particularly in pancreatic acinar cells .

HY-P2377

Ac-YVAD-AFC 2 Publications Verification	Fluorescent Dye	Others
Ac-YVAD-AFC is the the fluorometric peptide substrate of caspase-1, with λ excitation of 400 nm and λ emission of 505 nm .

HY-P2616

Mca-YVADAP-Lys(Dnp)-OH	Caspase Angiotensin-converting Enzyme (ACE)	Others
Mca-YVADAP-Lys(Dnp)-OH is a fluorogenic substrate for *caspase-1* and angiotensin-converting enzyme 2 (ACE2) .

HY-P10240

Ac-WVAD-AMC	Fluorescent Dye	Others
Ac-WVAD-AMC is a fluorogenic substrate for caspase 1 .

HY-P1986

Z-DEVD-AFC	Caspase	Cancer
Z-DEVD-AFC is a cell-permeant substrate for caspase-3, which causes a shift in fluorescence uponcleavage of the AFC fluorophore. Z-DEVD-AFC can be used to detect caspase-3-like enzymes activity .

HY-P2616A

Mca-YVADAP-Lys(Dnp)-OH TFA	Cholinesterase (ChE) Caspase	Others
Mca-YVADAP-Lys(Dnp)-OH TFA is a fluorogenic substrate for caspase-1 and angiotensin-converting enzyme 2 (ACE2) .

HY-P10001

Z-IETD-pNA Z-Ile-Glu-Thr-Asp-pNA	Caspase	Cancer
Z-IETD-pNA (Z-Ile-Glu-Thr-Asp-pNA) is a colorimetric caspase-8 and granzyme B substrate. Z-IETD-pNA is hydrlyzed by caspase 8 to generate pNA .

HY-120833

Ac-Ile-Glu-Thr-Asp-pNA	Caspase	Others
Ac-Ile-Glu-Thr-Asp-pNA is a substrate for caspase-8. Caspase-8 binds to and cleaves the Ile-Glu-Thr-Asp (IETD) peptide sequence to release p-nitroalinide, which can be quantified by colorimetric detection at 405 nm as a measure of enzyme activity .

HY-P2065

Ac-VEID-AMC	Fluorescent Dye	Others
Ac-VEID-AMC is a fluorescent substrate for the determination of *caspase-6* and related cysteine protease activities (Ex=340-360 nm, Em=440-460 nm) .

HY-P1003

Ac-DEVD-AMC 4 Publications Verification	Fluorescent Dye	Others
Ac-DEVD-AMC is a fluorescent substrate of caspase-3/caspase-7. When treating Ac-DEVD-AMC with cell lysate, Ac-DEVD-AMC releases amino-4-methylcoumarin (AMC) for fluorescence detection, with an excitation wavelength of 380 nm and an emission wavelength of 460 nm .

HY-P10142

Ac-YEVD-AMC	Fluorescent Dye	Others
Ac-YEVD-AMC is a fluorescent substrate of *caspase-1/11*. Ac-YEVD-AMC releases amino-4-methylcoumarin (AMC) for fluorescence detection when treating with cell lysate .

HY-P10666

Ac-VDQQD-pNA	Caspase	Others
Ac-VDQQD-pNA is a substrate of Caspase 2 and can be cleaved to produce yellow pNA (p-nitroaniline) .

HY-P2610

Ac-VEID-pNA	Caspase	Others
Ac-VEID-pNA is an artificially synthesized peptide. Ac-VEID-pNA is utilized as substrate for caspase 6, that cleaves the lamin A at the cleavage site of VEID .

HY-124134

AD-2646 LCL102	Ceramidase Caspase PARP	Cancer
AD-2646 (LCL102), a ceramide analog, can kill leukemic T cells (EC₅₀: 40 μM). AD-2646 triggers the cleavage of caspase-8, -9 and -3, as well as the caspase substrate PARP. AD-2646 is a ceramidase inhibitor. AD-2646 induces an accumulation of endogenous ceramide owing to perturbed ceramide metabolism .

HY-P3110

Ac-DNLD-AMC	Fluorescent Dye	Others
Ac-WLA-AMC is a fluorogenic substrate of caspase-3. Ac-WLA-AMC is cleaved to release the fluorescent moiety 7-amino-4-methylcoumarin (AMC), which can be used to quantify the β5c subunit activity .

HY-P10082

Ac-VETD-AMC	Caspase	Others
Ac-VETD-AMC is a synthetic peptide substrate for caspase 8. Ac-VETD-AMC also has potential to assess functional activity of recombinant phytaspase .

HY-P4400

Z-VDVAD-AFC	Fluorescent Dye	Others
Z-VDVAD-AFC is a fluorogenic substrate. Z-VDVAD-AFC is used to measure the activity of cysteine protease 3 (Caspase-3). Z-VDVAD-AFC undergoes hydrolysis to release 7-amino-4-trifluoromethylcoumarin (AFC). AFC is fluorescent under ultraviolet light and can emit fluorescent signals .

HY-P2016

Ac-Nle-Pro-Nle-Asp-AMC	Proteasome	Others
Ac-Nle-Pro-Nle-Asp-AMC is a specific substrate for 26S proteasome. Ac-Nle-Pro-Nle-Asp-AMC can be used for the 26S proteasome caspase-like activity analysis .

HY-P2630

Suc-YVAD-pNA	Interleukin Related	Inflammation/Immunology
Suc-YVAD-pNA is a substrate of ICE. Interleukin-1β-converting enzyme (ICE) is a cysteine protease responsible for the cleavage of pre-interleukin-1β (pre-IL-1β) to the mature cytokine and a member of a family of related proteases (the caspases) .

Cat. No.	Product Name	Type

HY-P1169

Ac-IETD-AFC 1 Publications Verification	Fluorescent Dyes/Probes
Ac-IETD-AFC is a fluorogenic substrate of caspase-8, caspase-3, caspase-10, and granzyme B .

HY-P3363

Z-DEVD-AMC	Chromogenic Substrates
Z-DEVD-AMC is a selective caspase-3 substrate that can be measured by fluorescence spectrometry. AMC can be used as a fluorescence reference standard for AMC-based enzyme substrates including AMC-based caspase substrates .

HY-P1093

Ac-LEHD-AFC 1 Publications Verification	Chromogenic Substrates
Ac-LEHD-AFC is a fluorescent substrate for caspase-9, can be used to assess the activity of caspase .

HY-P2208

Z-IETD-AFC	Fluorescent Dyes/Probes
Z-IETD-AFC, a specific fluorescence substrate, can be used to determine the caspase-8 catalytic activity .

HY-P2377

Ac-YVAD-AFC 2 Publications Verification	Dyes
Ac-YVAD-AFC is the the fluorometric peptide substrate of caspase-1, with λ excitation of 400 nm and λ emission of 505 nm .

HY-P3475

Mca-VDQMDGW-K(Dnp)-NH2	Fluorescent Dyes/Probes
Mca-VDQMDGWK-(Dnp)-NH2 is a fluorogenic substrate for caspase-3 and can be used to quantify caspase-3 activity .

HY-P2614

Mca-DEVDAP-K(Dnp)-OH	Chromogenic Substrates
Mca-DEVDAP-K(Dnp)-OH is a fluorogenic substrate for *caspase-3* .

HY-W338079

Ac-Asp-Glu-Val-Asp-pNA	Fluorescent Dyes/Probes
Ac-Asp-Glu-Val-Asp-pNA is a peptidic substrate of caspase-3/7 .

HY-P3362

Ac-IETD-AMC	Fluorescent Dyes/Probes
Ac-IETD-AMC is a fluorogenic caspase-8/granzyme B substrate containing the acetyl (Ac) moiety. Ac-IETD-AMC is frequently used to measure caspase-8 activity .

HY-P2616

Mca-YVADAP-Lys(Dnp)-OH	Chromogenic Substrates
Mca-YVADAP-Lys(Dnp)-OH is a fluorogenic substrate for *caspase-1* and angiotensin-converting enzyme 2 (ACE2) .

HY-P1986

Z-DEVD-AFC	Fluorescent Dyes/Probes
Z-DEVD-AFC is a cell-permeant substrate for caspase-3, which causes a shift in fluorescence uponcleavage of the AFC fluorophore. Z-DEVD-AFC can be used to detect caspase-3-like enzymes activity .

HY-P2065

Ac-VEID-AMC	Fluorescent Dyes/Probes
Ac-VEID-AMC is a fluorescent substrate for the determination of *caspase-6* and related cysteine protease activities (Ex=340-360 nm, Em=440-460 nm) .

HY-P1003

Ac-DEVD-AMC 4 Publications Verification	Chromogenic Substrates
Ac-DEVD-AMC is a fluorescent substrate of caspase-3/caspase-7. When treating Ac-DEVD-AMC with cell lysate, Ac-DEVD-AMC releases amino-4-methylcoumarin (AMC) for fluorescence detection, with an excitation wavelength of 380 nm and an emission wavelength of 460 nm .

HY-P3110

Ac-DNLD-AMC	Dyes
Ac-WLA-AMC is a fluorogenic substrate of caspase-3. Ac-WLA-AMC is cleaved to release the fluorescent moiety 7-amino-4-methylcoumarin (AMC), which can be used to quantify the β5c subunit activity .

Cat. No.	Product Name	Target	Research Area

HY-P2091

Ac-YVAD-pNA	Caspase	Inflammation/Immunology
Ac-YVAD-pNA is a specific *Caspase-1* substrate. Ac-YVAD-pNA can be used to detect Caspase-1 activity. Caspase-1 is a key mediator of inflammatory processes .

HY-P2617A

Ac-WEHD-AFC TFA	Caspase	Inflammation/Immunology Cancer
Ac-WEHD-AFC TFA is a fluorogenic caspase-1 substrate. Ac-WEHD-AFC TFA can measure caspase-1 fluorogenic activity and can be used for the research of tumor and inflammation .

HY-P1169

Ac-IETD-AFC 1 Publications Verification	Caspase	Others
Ac-IETD-AFC is a fluorogenic substrate of caspase-8, caspase-3, caspase-10, and granzyme B .

HY-P10145

Ac-LEVD-pNA	Peptides	Others
Ac-LEVD-pNA is a chromogenic substrate for caspase-4 and can be used to detect caspase-4 activity .

HY-P10450

(Asp)2-Rhodamine 110 D2R; (D)2-Rhodamine 110	Caspase	Others
(Asp)2-Rhodamine 110 (D2R) is a fluorescent caspase substrate .

HY-P10083

Ac-VQVD-pNA	Fluorescent Dye	Others
Ac-VQVD-pNA is a chromogenic substrate of *caspase* 3 .

HY-P2615

Ac-VDVAD-AFC	Fluorescent Dye	Cancer
Ac-VDVAD-AFC is a caspase-specific fluorescent substrate. Ac-VDVAD-AFC can measure caspase-3-like activity and caspase-2 activity and can be used for the research of tumor and cancer .

HY-P2615A

Ac-VDVAD-AFC TFA	Fluorescent Dye	Cancer
Ac-VDVAD-AFC TFA is a caspase-specific fluorescent substrate. Ac-VDVAD-AFC TFA can measure caspase-3-like activity and caspase-2 activity and can be used for the research of tumor and cancer .

HY-P4403

Z-DEVD-R110 (Z-Asp-Glu-Val-Asp)₂-Rhodamine 110	Fluorescent Dye Apoptosis Caspase	Others
Z-DEVD-R110 ((Z-Asp-Glu-Val-Asp)₂-Rhodamine 110) is a fluorogenic caspase-3/7 substrate. Z-DEVD-R110 can be used to detect apoptosis. Z-DEVD-R110 is a rhodamine derivative with two four–amino acid (DEVD) peptides linked to the fuorophore .

HY-P2617

Ac-WEHD-AFC	Caspase	Inflammation/Immunology Cancer
Ac-WEHD-AFC is a fluorogenic caspase-1 substrate. Ac-WEHD-AFC can measure caspase-1 fluorogenic activity and can be used for the research of tumor and inflammation .

HY-P3363

Z-DEVD-AMC	Caspase	Cancer
Z-DEVD-AMC is a selective caspase-3 substrate that can be measured by fluorescence spectrometry. AMC can be used as a fluorescence reference standard for AMC-based enzyme substrates including AMC-based caspase substrates .

HY-P4392

Z-VAD-AMC	Caspase	Others
Z-VAD-AMC is a substrate of caspase-9 .

HY-P4401

Z-VEID-AFC	Caspase	Others
Z-VEID-AFC is a fluorescent substrate for caspase-6 .

HY-P4429

Z-YVAD-AFC	Peptides	Others
Z-YVAD-AFC is a fluorescent substrate for Caspase-1, which can be used to detect and measure the activity of Caspase-1 .

HY-W713878

Ac-VDVAD-pNA	Caspase	Others
Ac-VDVAD-pNA is a *caspase-2* substrate. Ac-VDVAD-pNA can be used to test the activity of caspase-2 .

HY-P10084

Ac-VAD-pNA	Caspase	Others
Ac-VAD-pNA is a *caspase-1* substrate. Ac-VAD-pNA can be used to detect caspase-1 activity .

HY-P10452

Ac-LEVDGWK(Dnp)-NH2	Caspase	Others
Ac-LEVDGWK(Dnp)-NH2 is a substrate for *Caspase-3, and can be used to detect Caspase*-3 activity .

HY-P5983

Ac-VEID-AFC	Caspase	Cancer
Ac-VEID-AFC is a *caspase-6* fluorogenic substrate, and can be used in the caspase 6 activity assay .

HY-P5348

Ac-LEHD-pNA	Peptides	Others
Ac-LEHD-pNA is a biological active peptide. (Caspase-9 substrate; pNA (4-nitroaniline)-derived caspase substrates are widely used for the colorimetric detection of various caspase activities. Cleavage of pNA peptides by caspases generates pNA that is monitored colorimetrically at ~405 nm. pNA has maximum absorption around 408 nm.)

HY-P3475

Mca-VDQMDGW-K(Dnp)-NH2	Fluorescent Dye	Others
Mca-VDQMDGWK-(Dnp)-NH2 is a fluorogenic substrate for caspase-3 and can be used to quantify caspase-3 activity .

HY-P2614

Mca-DEVDAP-K(Dnp)-OH	Caspase	Others
Mca-DEVDAP-K(Dnp)-OH is a fluorogenic substrate for *caspase-3* .

HY-P10276

Ac-VAD-AFC	Caspase	Cancer
Ac-VAD-AFC is a fluorescent substrate for caspases and can be used to test the activity of caspases .

HY-P1006

Ac-DEVD-pNA 1 Publications Verification	Caspase	Others
Ac-DEVD-pNA is a colorimetric substrate for caspase-3 (CPP32) and related cysteine proteases.

HY-P5974

Z-YVAD-pNA Z-Tyr-Val-Ala-Asp-pNA	Caspase	Others
Z-YVAD-pNA (Z-Tyr-Val-Ala-Asp-pNA) is a *caspase-1* substrate .

HY-P2208

Z-IETD-AFC	Fluorescent Dye	Cancer
Z-IETD-AFC, a specific fluorescence substrate, can be used to determine the caspase-8 catalytic activity .

HY-P3362

Ac-IETD-AMC	Fluorescent Dye	Others
Ac-IETD-AMC is a fluorogenic caspase-8/granzyme B substrate containing the acetyl (Ac) moiety. Ac-IETD-AMC is frequently used to measure caspase-8 activity .

HY-P3476

Mca-VDQVDGW-Lys(Dnp)-NH2	CRISPR/Cas9	Cancer
Mca-VDQVDGW-Lys(Dnp)-NH2 is a fluorogenic substrate of caspase-7. Mca-VDQVDGW-K(Dnp)-NH2 can be used to quantify caspase-7 activity.

HY-P10454

(Z-IETD)2-Rh 110 (Z-Ile-Glu-Thr-Asp)2-R110	Caspase	Others
(Z-IETD)2-Rh 110 is a fluorescent substrate of *caspase-8* (λex= 488 nm, λem= 523 nm), which can be used to detect the activity of *caspase-8* and the process of apoptosis .

HY-P10236

Ac-WEHD-pNA	Caspase	Others
Ac-WEHD-pNA is a colorimetric substrate for *caspase* 1, 4, 5 and 14, which is utilized to measure the caspase activity .

HY-P4547

Ac-Trp-Glu-His-Asp-AMC AC-WEHD-AMC	Caspase	Others
Ac-Trp-Glu-His-Asp-AMC (AC-WEHD-AMC) is a potent fluorogenic substrate of caspase-1 .

HY-P2620

Ac-LETD-AFC	Fluorescent Dye	Metabolic Disease Cancer
Ac-LETD-AFC is a **caspase-8 fluorogenic substrate*. Ac-LETD-AFC can measure caspase*-8 fluorogenic activity and can be used for the research of cancer cell apoptosis and oxidative stress metabolism .

HY-P10322

Z-IETD-R110	Fluorescent Dye	Cancer
Z-IETD-R110 is a fluorescent substrate of *caspases. Z-IETD-R110 acts as a substrate* for *caspase-8. When caspase-8* is activated, it can recognize and cut Z-IETD-R110, releasing fluorophore, which can be detected by fluorescence microscopy. Z-IETD-R110 can be used to study oxidative stress-induced apoptosis, particularly in pancreatic acinar cells .

HY-P2377

Ac-YVAD-AFC 2 Publications Verification	Fluorescent Dye	Others
Ac-YVAD-AFC is the the fluorometric peptide substrate of caspase-1, with λ excitation of 400 nm and λ emission of 505 nm .

HY-P2616

Mca-YVADAP-Lys(Dnp)-OH	Caspase Angiotensin-converting Enzyme (ACE)	Others
Mca-YVADAP-Lys(Dnp)-OH is a fluorogenic substrate for *caspase-1* and angiotensin-converting enzyme 2 (ACE2) .

HY-P3115

Ac-LEVD-AFC	Peptides	Others
Ac-LEVD-AFC is capspase-4 fluorogenic substrate peptide that can be used for caspase-4 activity studies .

HY-P10240

Ac-WVAD-AMC	Fluorescent Dye	Others
Ac-WVAD-AMC is a fluorogenic substrate for caspase 1 .

HY-P1986

Z-DEVD-AFC	Caspase	Cancer
Z-DEVD-AFC is a cell-permeant substrate for caspase-3, which causes a shift in fluorescence uponcleavage of the AFC fluorophore. Z-DEVD-AFC can be used to detect caspase-3-like enzymes activity .

HY-P2616A

Mca-YVADAP-Lys(Dnp)-OH TFA	Cholinesterase (ChE) Caspase	Others
Mca-YVADAP-Lys(Dnp)-OH TFA is a fluorogenic substrate for caspase-1 and angiotensin-converting enzyme 2 (ACE2) .

HY-P10001

Z-IETD-pNA Z-Ile-Glu-Thr-Asp-pNA	Caspase	Cancer
Z-IETD-pNA (Z-Ile-Glu-Thr-Asp-pNA) is a colorimetric caspase-8 and granzyme B substrate. Z-IETD-pNA is hydrlyzed by caspase 8 to generate pNA .

HY-120833

Ac-Ile-Glu-Thr-Asp-pNA	Caspase	Others
Ac-Ile-Glu-Thr-Asp-pNA is a substrate for caspase-8. Caspase-8 binds to and cleaves the Ile-Glu-Thr-Asp (IETD) peptide sequence to release p-nitroalinide, which can be quantified by colorimetric detection at 405 nm as a measure of enzyme activity .

HY-P2065

Ac-VEID-AMC	Fluorescent Dye	Others
Ac-VEID-AMC is a fluorescent substrate for the determination of *caspase-6* and related cysteine protease activities (Ex=340-360 nm, Em=440-460 nm) .

HY-P1003

Ac-DEVD-AMC 4 Publications Verification	Fluorescent Dye	Others
Ac-DEVD-AMC is a fluorescent substrate of caspase-3/caspase-7. When treating Ac-DEVD-AMC with cell lysate, Ac-DEVD-AMC releases amino-4-methylcoumarin (AMC) for fluorescence detection, with an excitation wavelength of 380 nm and an emission wavelength of 460 nm .

HY-P10142

Ac-YEVD-AMC	Fluorescent Dye	Others
Ac-YEVD-AMC is a fluorescent substrate of *caspase-1/11*. Ac-YEVD-AMC releases amino-4-methylcoumarin (AMC) for fluorescence detection when treating with cell lysate .

HY-P10666

Ac-VDQQD-pNA	Caspase	Others
Ac-VDQQD-pNA is a substrate of Caspase 2 and can be cleaved to produce yellow pNA (p-nitroaniline) .

HY-P2610

Ac-VEID-pNA	Caspase	Others
Ac-VEID-pNA is an artificially synthesized peptide. Ac-VEID-pNA is utilized as substrate for caspase 6, that cleaves the lamin A at the cleavage site of VEID .

HY-P3110

Ac-DNLD-AMC	Fluorescent Dye	Others
Ac-WLA-AMC is a fluorogenic substrate of caspase-3. Ac-WLA-AMC is cleaved to release the fluorescent moiety 7-amino-4-methylcoumarin (AMC), which can be used to quantify the β5c subunit activity .

HY-P10082

Ac-VETD-AMC	Caspase	Others
Ac-VETD-AMC is a synthetic peptide substrate for caspase 8. Ac-VETD-AMC also has potential to assess functional activity of recombinant phytaspase .

HY-P10244F

Biotin-YVAD-FMK	Peptides	Infection
Biotin-YVAD-FMK is an inhibitor for vacuolar processing enzyme (VPE), with a 64% inhibition at 5 μM. Biotin-YVAD-FMK is an irreversible substrate for caspase 1 .

HY-P4400

Z-VDVAD-AFC	Fluorescent Dye	Others
Z-VDVAD-AFC is a fluorogenic substrate. Z-VDVAD-AFC is used to measure the activity of cysteine protease 3 (Caspase-3). Z-VDVAD-AFC undergoes hydrolysis to release 7-amino-4-trifluoromethylcoumarin (AFC). AFC is fluorescent under ultraviolet light and can emit fluorescent signals .

HY-P10161

Ac-DMQD-pNA	Peptides	Others
Ac-DMQD-pNA is a peptide substrate. Both of the recombinant CgCaspase-1 (rCgCaspase-1) and the C-terminus of CgCaspase-1 (rCgCaspase-1-C) exhibits similar caspase activity towards proteolytic substrate Ac-DMQD-pNA and Ac-DEVD-pNA (HY-P1006) .

Cat. No.	Product Name

HY-K1088

VF 488 Caspase 3 Assay Kit for Live Cells
MCE VF 488 Caspase 3 Assay Kit for Live Cells uses a fluorescent substrate with cell membrane permeability to detect Caspase 3 activity in live cells.

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