2. Apoptosis
  3. Caspase
  4. Ac-YVAD-pNA

Ac-YVAD-pNA is a specific Caspase-1 substrate. Ac-YVAD-pNA can be used to detect Caspase-1 activity. Caspase-1 is a key mediator of inflammatory processes.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

Ac-YVAD-pNA Chemical Structure

Ac-YVAD-pNA Chemical Structure

CAS No. : 149231-66-3

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5 mg USD 90 In-stock
10 mg USD 145 In-stock
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Based on 1 publication(s) in Google Scholar

Ac-YVAD-pNA Related Antibodies

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Caspase 1 Caspase 2 Caspase 3 Caspase 4 Caspase 5 Caspase 6 Caspase 7 Caspase 8 Caspase 9 Caspase 10 Caspase 12 Caspase Caspase 11 Caspase-13

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Description

Ac-YVAD-pNA is a specific Caspase-1 substrate. Ac-YVAD-pNA can be used to detect Caspase-1 activity. Caspase-1 is a key mediator of inflammatory processes[1][2].

IC50 & Target[1]

Caspase-1

 

Molecular Weight

628.63

Formula

C29H36N6O10
CAS No.
Appearance

Solid

Color

White to off-white

Sequence

Ac-Tyr-Val-Ala-Asp-{pNA}
Sequence Shortening

Ac-YVAD-{pNA}
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture and light

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

DMSO : ≥ 250 mg/mL (397.69 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.5908 mL 7.9538 mL 15.9076 mL
5 mM 0.3182 mL 1.5908 mL 3.1815 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.5908 mL 7.9538 mL 15.9076 mL 39.7690 mL
5 mM 0.3182 mL 1.5908 mL 3.1815 mL 7.9538 mL
10 mM 0.1591 mL 0.7954 mL 1.5908 mL 3.9769 mL
15 mM 0.1061 mL 0.5303 mL 1.0605 mL 2.6513 mL
20 mM 0.0795 mL 0.3977 mL 0.7954 mL 1.9885 mL
25 mM 0.0636 mL 0.3182 mL 0.6363 mL 1.5908 mL
30 mM 0.0530 mL 0.2651 mL 0.5303 mL 1.3256 mL
40 mM 0.0398 mL 0.1988 mL 0.3977 mL 0.9942 mL
50 mM 0.0318 mL 0.1591 mL 0.3182 mL 0.7954 mL
60 mM 0.0265 mL 0.1326 mL 0.2651 mL 0.6628 mL
80 mM 0.0199 mL 0.0994 mL 0.1988 mL 0.4971 mL
100 mM 0.0159 mL 0.0795 mL 0.1591 mL 0.3977 mL
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Ac-YVAD-pNA Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ac-YVAD-pNA149231-66-3CaspaseCaspase substrateinflammationInhibitorinhibitorinhibit

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