(Z-IETD)2-Rh 110  (Synonyms: (Z-Ile-Glu-Thr-Asp)2-R110)

(Z-IETD)2-Rh 110 is a fluorescent substrate of caspase-8 (λex= 488 nm, λem= 523 nm), which can be used to detect the activity of caspase-8 and the process of apoptosis^[1].

1515.53

C₇₄H₈₆N₁₀O₂₅

{Z-Ile}-Glu-Thr-Asp-{Rhodamine 110}-Asp-Thr-Glu-{Z-Ile}

{Z-Ile}-ETD-{Rhodamine 110}-DTE-{Z-Ile}

OC(C[C@@H](C(NC1=CC=C2C3(C4=C(OC2=C1)C=C(NC([C@@H](NC([C@@]([C@@H](C)O)([H])NC([C@@H](NC([C@](NC(OCC5=CC=CC=C5)=O)([H])[C@@H](C)CC)=O)CCC(O)=O)=O)=O)CC(O)=O)=O)C=C4)C6=C(C(O3)=O)C=CC=C6)=O)NC([C@]([H])([C@H](O)C)NC([C@H](CCC(O)=O)NC([C@@]([H])(NC(OCC7=CC=CC=C7)=O)[C@H](CC)C)=O)=O)=O)=O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Kim M J, et al. Multicolor single cell imaging cytometry: A new drug screening platform for monitoring intracellular caspases as potential therapeutic targets[C]//2010 IEEE International Conference on Nano/Molecular Medicine and Engineering. IEEE, 2010: 239-242.