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  3. Fluorescent Dye
  4. Ac-YEVD-AMC

Ac-YEVD-AMC is a fluorescent substrate of caspase-1/11. Ac-YEVD-AMC releases amino-4-methylcoumarin (AMC) for fluorescence detection when treating with cell lysate.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

Ac-YEVD-AMC Chemical Structure

Ac-YEVD-AMC Chemical Structure

CAS No. : 1631716-11-4

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1 mg USD 60 In-stock
5 mg USD 130 In-stock
10 mg USD 210 In-stock
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Based on 1 publication(s) in Google Scholar

Ac-YEVD-AMC Related Antibodies

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Description

Ac-YEVD-AMC is a fluorescent substrate of caspase-1/11. Ac-YEVD-AMC releases amino-4-methylcoumarin (AMC) for fluorescence detection when treating with cell lysate[1].

Molecular Weight

723.73

Formula

C35H41N5O12
CAS No.
Appearance

Solid

Color

White to off-white

Sequence

Ac-Tyr-Glu-Val-Asp-{AMC}
Sequence Shortening

Ac-YEVD-{AMC}
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (138.17 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.3817 mL 6.9087 mL 13.8173 mL
5 mM 0.2763 mL 1.3817 mL 2.7635 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.3817 mL 6.9087 mL 13.8173 mL 34.5433 mL
5 mM 0.2763 mL 1.3817 mL 2.7635 mL 6.9087 mL
10 mM 0.1382 mL 0.6909 mL 1.3817 mL 3.4543 mL
15 mM 0.0921 mL 0.4606 mL 0.9212 mL 2.3029 mL
20 mM 0.0691 mL 0.3454 mL 0.6909 mL 1.7272 mL
25 mM 0.0553 mL 0.2763 mL 0.5527 mL 1.3817 mL
30 mM 0.0461 mL 0.2303 mL 0.4606 mL 1.1514 mL
40 mM 0.0345 mL 0.1727 mL 0.3454 mL 0.8636 mL
50 mM 0.0276 mL 0.1382 mL 0.2763 mL 0.6909 mL
60 mM 0.0230 mL 0.1151 mL 0.2303 mL 0.5757 mL
80 mM 0.0173 mL 0.0864 mL 0.1727 mL 0.4318 mL
100 mM 0.0138 mL 0.0691 mL 0.1382 mL 0.3454 mL
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Ac-YEVD-AMC Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ac-YEVD-AMC1631716-11-4Fluorescent DyeCaspase-1Caspase-11Fluorescent SubstrateInhibitorinhibitorinhibit

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