Ac-Nle-Pro-Nle-Asp-AMC

Cat. No.: HY-P2016 Purity: 99.85%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Ac-Nle-Pro-Nle-Asp-AMC is a specific substrate for 26S proteasome. Ac-Nle-Pro-Nle-Asp-AMC can be used for the 26S proteasome caspase-like activity analysis.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

Ac-Nle-Pro-Nle-Asp-AMC Chemical Structure

CAS No. : 355140-49-7

Size	Price	Stock	Quantity
1 mg	USD 220	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 820	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 1320	In-stock	Estimated Time of Arrival: December 31
50 mg		Get quote
100 mg		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

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Biological Activity
Purity & Documentation
References
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Description

Ac-Nle-Pro-Nle-Asp-AMC is a specific substrate for 26S proteasome. Ac-Nle-Pro-Nle-Asp-AMC can be used for the 26S proteasome caspase-like activity analysis^[1]^[2]^[3].

Molecular Weight

655.74

Formula

C₃₃H₄₅N₅O₉

CAS No.

355140-49-7

Appearance

Solid

Color

White to off-white

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Sealed storage, away from moisture

Powder	-80°C	2 years
	-20°C	1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : ≥ 100 mg/mL (152.50 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.5250 mL	7.6250 mL	15.2499 mL
5 mM	0.3050 mL	1.5250 mL	3.0500 mL
10 mM	0.1525 mL	0.7625 mL	1.5250 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.85%

Select Batch:

Data Sheet (272 KB) SDS (252 KB)

COA (251 KB) LCMS (90 KB) Elemental Analysis Report (110 KB)

Handling Instructions (2659 KB)

References

[1]. Dunlop RA, et al. The impact of specific oxidized amino acids on protein turnover in J774 cells. Biochem J. 2008 Feb 15;410(1):131-40. [Content Brief]

[2]. Kirk-Ballard H, et al. An extract of Artemisia dracunculus L. inhibits ubiquitin-proteasome activity and preserves skeletal muscle mass in a murine model of diabetes. PLoS One. 2013;8(2):e57112. [Content Brief]

[3]. Pakavathkumar P, et al. Methylene Blue Inhibits Caspases by Oxidation of the Catalytic Cysteine. Sci Rep. 2015 Sep 24;5:13730. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.5250 mL	7.6250 mL	15.2499 mL	38.1249 mL
	5 mM	0.3050 mL	1.5250 mL	3.0500 mL	7.6250 mL
	10 mM	0.1525 mL	0.7625 mL	1.5250 mL	3.8125 mL
	15 mM	0.1017 mL	0.5083 mL	1.0167 mL	2.5417 mL
	20 mM	0.0762 mL	0.3812 mL	0.7625 mL	1.9062 mL
	25 mM	0.0610 mL	0.3050 mL	0.6100 mL	1.5250 mL
	30 mM	0.0508 mL	0.2542 mL	0.5083 mL	1.2708 mL
	40 mM	0.0381 mL	0.1906 mL	0.3812 mL	0.9531 mL
	50 mM	0.0305 mL	0.1525 mL	0.3050 mL	0.7625 mL
	60 mM	0.0254 mL	0.1271 mL	0.2542 mL	0.6354 mL
	80 mM	0.0191 mL	0.0953 mL	0.1906 mL	0.4766 mL
	100 mM	0.0152 mL	0.0762 mL	0.1525 mL	0.3812 mL