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Results for "

Caspase-2 Inhibitor

" in MedChemExpress (MCE) Product Catalog:

11

Inhibitors & Agonists

6

Peptides

2

Oligonucleotides

Targets Recommended:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-P1008
    Z-VDVAD-FMK
    1 Publications Verification

    Z-VD(OMe)VAD(OMe)-FMK

    		 Caspase Cancer
    Z-VDVAD-FMK is a special inhibitor of caspase-2. Z-VDVAD-FMK produces a reduction in Lovastatin-induced apoptosis .
    Z-VDVAD-FMK
  • HY-164388
    Z-VAD
    2 Publications Verification

    		 Caspase Apoptosis Autophagy Necroptosis Cardiovascular Disease Cancer
    Z-VAD is a competitive, irreversible pan-caspase inhibitor. Z-VAD inhibits all 10 caspases, except for caspase-2 which is only weakly inhibited. Z-VAD decreases radiation-induced apoptosis. Z-VAD induces both autophagy and necrosis in irradiated MDA-MB-231 and H460 mouse xenografts. Z-VAD with radiation produces a significant tumor growth delay and shows dramatic antiangiogenic effect in cancer xenograft .
    Z-VAD
  • HY-120838
    Heptelidic acid

    Koningic acid

    		 Caspase Infection Cancer
    Heptelidic acid (Koningic acid) is a sesquiterpene antibiotic . Heptelidic acid inhibits Etoposide-induced apoptosis via downregulation of caspases . Koningic acid (KA) is a specific GAPDH inhibitor with an IC50of 90 μM .
    Heptelidic acid
  • HY-158820A
    Cosdosiran sodium

    QPI-1007 sodium

    		 Small Interfering RNA (siRNA) Caspase Cardiovascular Disease
    Cosdosiran sodium is a chemically modified siRNA designed to temporarily inhibit expression of the caspase 2 protein and can be used for the study of nonarteritic anterior ischemic optic neuropathy and other optic neuropathies such as glaucoma that result in the death of retinal ganglion cells.?
    Cosdosiran sodium
  • HY-P10147
    Ac-LDESD-AMC

    		Caspase Cancer
    Ac-LDESD-AMC is a caspase-2 inhibitor. Ac-LDESD-AMC has a peptide sequence of Leu-Asp-Glu-Ser-Asp .
    Ac-LDESD-AMC
  • HY-P1008A
    Z-VDVA-(DL-Asp)-FMK

    Z-VD(OMe)VAD(OMe)-(DL-Asp)-FMK

    		 Caspase Cancer
    Z-VDVA-(DL-Asp)-FMK is a Z-VDVAD-FMK derivative. Z-VDVAD-FMK (HY-P1008) is a special inhibitor of caspase-2 .
    Z-VDVA-(DL-Asp)-FMK
  • HY-P2012
    TRP-601

    		Caspase Bcl-2 Family Others
    TRP-601 is a caspase inhibitor. TRP-601 reversed the increased expression of active caspase-2, the activation of endogenous apoptotic pathway and the up-regulation of key protein triggered by hyperoxia .
    TRP-601
  • HY-P0109
    (S,S)-Z-FA-FMK

    		Cathepsin Others
    (S,S)-Z-FA-FMK is a cell-permeable, irreversible cathepsin B inhibitor. (S,S)-Z-FA-FMK blocks LPS-induced production of IL-1α and IL-1β. (S,S)-Z-FA-FMK can be used as a negative control for caspase-1 and caspase-2 inhibitors because it lacks an aspartic acid residue at the P1 position .
    (S,S)-Z-FA-FMK
  • HY-134567
    Ac-VDVAD-CHO

    		Casein Kinase Others
    Ac-VDVAD-CHO is a caspase-2/3 inhibitor (IC50: 46 and 15 nM) .
    Ac-VDVAD-CHO
  • HY-158820
    Cosdosiran

    QPI-1007

    		 Small Interfering RNA (siRNA) Caspase Cardiovascular Disease
    Cosdosiran is a chemically modified siRNA designed to temporarily inhibit expression of the caspase 2 protein and can be used for the study of nonarteritic anterior ischemic optic neuropathy and other optic neuropathies such as glaucoma that result in the death of retinal ganglion cells.?
    Cosdosiran
  • HY-P0109A
    Z-FA-FMK
    4 Publications Verification

    (1S)-Z-FA-FMK

    		 SARS-CoV Cathepsin Apoptosis Caspase Infection Cancer
    Z-FA-FMK ((1S)-Z-FA-FMK) is a potent Cathepsin B and L inhibitor. Z-FA-FMK blocks the induction of DEVDase activity, DNA fragmentation, and externalization of phosphatidylserine by selective synthetic retinoid-related molecules (RRMs). Z-FA-FMK inhibits apoptosis. Z-FA-FMK inhibits caspase activity and selectively inhibits recombinant effector caspases 2, -3, -6, and -7. Z-FA-FMK is a viral inhibitor. Z-FA-FMK inhibits reovirus replication in a susceptible host .
    Z-FA-FMK

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