TRP-601

Cat. No.: HY-P2012: FAQs
Data Sheet Handling Instructions

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TRP-601 is a caspase inhibitor. TRP-601 reversed the increased expression of active caspase-2, the activation of endogenous apoptotic pathway and the up-regulation of key protein triggered by hyperoxia.

For research use only. We do not sell to patients.

TRP-601 Chemical Structure

CAS No. : 1094569-02-4

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Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target

Caspase-2

Caspase 3

Bcl-2

In Vivo

TRP-601 (1 mg/kg, Intraperitoneal injection, single dose) reduces hyperoxia-induced caspase activation in rats, attenuates neuronal cell death in the developing brain in rats and inhibits intrinsic apoptotic signaling^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Wistar rats ^[1]
Dosage:	1 mg/kg
Administration:	Intraperitoneal injection (i.p.)
Result:	Ameliorated the increase of caspase-3 activity and reduced protein expression of processed caspase-2 and enzymatic activity. Significantly reduced neuronal cell death and did not influence levels of physiological apoptosis. Decreased Apaf-1 protein expression to control levels. Increased mRNA expression of Bcl-2.

Molecular Weight

826.84

Formula

C₄₀H₄₈F₂N₆O₁₁

CAS No.

1094569-02-4

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. M Sifringer, et al. Prevention of neonatal oxygen-induced brain damage by reduction of intrinsic apoptosis. Cell Death Dis. 2012 Jan 12;3(1):e250. [Content Brief]

[2]. Sifringer M, et al. Prevention of neonatal oxygen-induced brain damage by reduction of intrinsic apoptosis [J]. Cell death & disease, 2012, 3(1): e250-e250.

TRP-601 Related Classifications

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TRP-6011094569-02-4TRP601TRP 601CaspaseBcl-2 FamilyHyperoxiaInhibitorApoptosisinhibitorinhibit

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