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Isoforms Recommended:	ERRα

Results for "

ERRα

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Bacterial (1) E3 Ligase Ligand-Linker Conjugates (4) Endogenous Metabolite (1) Epigenetic Reader Domain (1) Estrogen Receptor/ERR (10) Liposome (1) PROTACs (4) Target Protein Ligand-Linker Conjugates (1)
By Research Areas:	Cancer (14) Metabolic Disease (2)
Oligonucleotides:	Emulsifiers (1)

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Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-130499

ERRα Ligand-Linker Conjugates 1	Target Protein Ligand-Linker Conjugates	Cancer
ERRα Ligand-Linker Conjugates 1 incorporates a ligand for *estrogen-related receptor alpha (ERRα), and a PROTAC linker, which recruit E3 ligases MDM2. ERRα Ligand-Linker Conjugates 1 can be used in the synthesis of a series of PROTACs, such as PROTAC ERRalpha Degrader-1 (HY-128838). PROTAC ERRalpha Degrader-1 is an ERR*α degrader .

HY-113960

ERRα antagonist-1	Estrogen Receptor/ERR	Cancer
ERRα antagonist-1 (Compound A) is a selective and high affinity *estrogen-related receptor α (ERRα)* antagonist. ERRα antagonist-1 inhibits interaction of ERRα with Proliferator-activated Receptor γ Coactivator-1α (PGC-1α) and PGC-1β, the IC₅₀ values are 170 nM and 180 nM, respectively. ERRα antagonist-1 does not inhibit the interaction of either ERRβ or ERRγ with PGC-1α and PGC-1β coactivator, and also does not inhibit interaction of ERα or ERβ with PGC-1α or SRC-1 .

HY-147174

PROTAC_ERRα	PROTACs Epigenetic Reader Domain	Cancer
PROTAC_ERRα is a potent and selective ERRα PROTAC degrader (DC₅₀: 100 nM in MCF-7 cells). PROTAC_ERRα induces proteasomal degradation and has capable of specifically degrading ERRα protein by >80%. Blue: VHL ligand (HY-125845), Pink: ERRα ligand (HY-U00425), black: linker .

HY-139185

*PROTAC ERRα* Degrader-3**	PROTACs Estrogen Receptor/ERR	Cancer
PROTAC ERRα Degrader-3 is a potent and selective ERRα degrader based on von Hippel-Lindau ligand. PROTAC ERRα Degrader-3 is capable of specifically degrading ERRα protein by >80% at a concentration of 30 nM. PROTAC ERRα Degrader-3 is inactive against ERRβ and ERRγ proteins .

HY-128838

*PROTAC ERRα* Degrader-1**	PROTACs Estrogen Receptor/ERR	Cancer
PROTAC ERRα Degrader-1 comprises a MDM2 ligand binding group, a linker and an estrogen-related receptor alpha (ERRa) binding group. PROTAC ERRα Degrader-1 is an PROTAC estrogen-related receptor alpha (ERRa) degrader .

HY-128838A

*(rel)-PROTAC ERRα* Degrader-1** 1 Publications Verification	Estrogen Receptor/ERR	Others
(rel)-PROTAC ERRα Degrader-1 is a relative configuration of PROTAC ERRα Degrader-1. PROTAC ERRα Degrader-1 comprises a MDM2 ligand binding group, a linker and an estrogen-related receptor alpha (ERRa) binding group. PROTAC ERRα Degrader-1 is an estrogen-related receptor alpha (ERRa) degrader .

HY-126351

*PROTAC ERRα* ligand 2**	Estrogen Receptor/ERR	Cancer
PROTAC ERRα ligand 2 is an estrogen-related receptor α (ERRα) inverse agonist with an IC₅₀ of 5.67 nM. PROTAC ERRα ligand 2 (IC₅₀=5.67 nM) displays a ~11-fold improved potency than XCT790 (IC₅₀=61.3 nM) .

HY-U00425

*PROTAC ERRα* ligand 1**	Estrogen Receptor/ERR	Cancer
PROTAC ERRα ligand 1 is an estrogen-related receptor α (ERRα) antagonist with IC₅₀s of 0.04 and 2.8 μM for ERRα and ERRγ, respectively .

HY-144699

ERRα antagonist-2	Estrogen Receptor/ERR	Cancer
ERRα antagonist-2 (Compound 11) is a potential ERRα (estrogen related receptor α) inverse agonist with an IC₅₀ of 0.80 μM. ERRα antagonist-2 suppresses the migration and invasion of the ER-negative MDA-MB-231 cell line. ERRα antagonist-2 inhibits breast cancer growth in vivo .

HY-128839

*PROTAC ERRα* Degrader-2**	PROTACs Estrogen Receptor/ERR	Cancer
PROTAC ERRα Degrader-2 comprises a MDM2 ligand binding group, a linker and an estrogen-related receptor alpha (ERRa) binding group. PROTAC ERRα Degrader-2 is an estrogen-related receptor alpha (ERRa) degrader .

HY-136186

(S,R,S)-AHPC-C7-amine VH032-C7-amine	E3 Ligase Ligand-Linker Conjugates	Cancer
(S,R,S)-AHPC-C7-amine (VH032-C7-amine) is a synthesized E3 ligase ligand-linker conjugate that incorporates the VH032 based VHL ligand and a linker used for estrogen-related receptor α (ERRα) PROTAC degrader .

HY-136187

(S,R,S)-AHPC-C5-NH2 VH032-C5-NH2	E3 Ligase Ligand-Linker Conjugates	Cancer
(S,R,S)-AHPC-C5-NH2 (VH032-C5-NH2) is a synthesized E3 ligase ligand-linker conjugate that incorporates the VH032 based VHL ligand and a linker used for estrogen-related receptor α (ERRα) PROTAC degrader .

HY-136187A

(S,R,S)-AHPC-C5-NH2 dihydrochloride VH032-C5-NH2 dihydrochloride	E3 Ligase Ligand-Linker Conjugates	Cancer
(S,R,S)-AHPC-C5-NH2 (VH032-C5-NH2) dihydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the VH032 based VHL ligand and a linker used for estrogen-related receptor α (ERRα) PROTAC degrader .

HY-136186A

(S,R,S)-AHPC-C7-amine dihydrochloride VH032-C7-amine dihydrochloride	E3 Ligase Ligand-Linker Conjugates	Cancer
(S,R,S)-AHPC-C7-amine dihydrochloride is the dihydrochloride form of (S,R,S)-AHPC-C7-amine (HY-136186). (S,R,S)-AHPC-C7-amine is a synthesized E3 ligase ligand-linker conjugate that incorporates the VH032 based VHL ligand and a linker. (S,R,S)-AHPC-C7-amine can be used for estrogen-related receptor α (ERRα) PROTAC degrader .

HY-143226

DK1	Estrogen Receptor/ERR	Metabolic Disease
DK1 is a potent modulator of estrogen related receptor. DK1 has an ability in reducing blood glucose, and impacts the activity of ERRα receptor. DK1 has the potential for the research of diabetes .

HY-N0322

Cholesterol Maximum Cited Publications 35 Publications Verification	Liposome Estrogen Receptor/ERR Endogenous Metabolite Bacterial	Metabolic Disease Cancer
Cholesterol is the major sterol in mammals. It is making up 20-25% of structural component of the plasma membrane. Plasma membranes are highly permeable to water but relatively impermeable to ions and protons. Cholesterol plays an important role in determining the fluidity and permeability characteristics of the membrane as well as the function of both the transporters and signaling proteins . Cholesterol is also an endogenous *estrogen-related receptor α (ERRα)* agonist .

Cat. No.	Product Name	Type

HY-N0322

Cholesterol 30+ Cited Publications	Drug Delivery
Cholesterol is the major sterol in mammals. It is making up 20-25% of structural component of the plasma membrane. Plasma membranes are highly permeable to water but relatively impermeable to ions and protons. Cholesterol plays an important role in determining the fluidity and permeability characteristics of the membrane as well as the function of both the transporters and signaling proteins . Cholesterol is also an endogenous *estrogen-related receptor α (ERRα)* agonist .

Cholesterol

30+ Cited Publications

Drug Delivery

Cholesterol is the major sterol in mammals. It is making up 20-25% of structural component of the plasma membrane. Plasma membranes are highly permeable to water but relatively impermeable to ions and protons. Cholesterol plays an important role in determining the fluidity and permeability characteristics of the membrane as well as the function of both the transporters and signaling proteins . Cholesterol is also an endogenous estrogen-related receptor α (ERRα) agonist .

Cholesterol 30+ Cited Publications	Structural Classification Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields Steroids Cancer	Liposome Estrogen Receptor/ERR Endogenous Metabolite Bacterial
Cholesterol is the major sterol in mammals. It is making up 20-25% of structural component of the plasma membrane. Plasma membranes are highly permeable to water but relatively impermeable to ions and protons. Cholesterol plays an important role in determining the fluidity and permeability characteristics of the membrane as well as the function of both the transporters and signaling proteins . Cholesterol is also an endogenous *estrogen-related receptor α (ERRα)* agonist .

Cat. No.	Product Name		Classification

HY-N0322

Cholesterol 30+ Cited Publications		Emulsifiers
Cholesterol is the major sterol in mammals. It is making up 20-25% of structural component of the plasma membrane. Plasma membranes are highly permeable to water but relatively impermeable to ions and protons. Cholesterol plays an important role in determining the fluidity and permeability characteristics of the membrane as well as the function of both the transporters and signaling proteins . Cholesterol is also an endogenous *estrogen-related receptor α (ERRα)* agonist .

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ERRα

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