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FD

" in MedChemExpress (MCE) Product Catalog:

36

Inhibitors & Agonists

8

Fluorescent Dye

1

Inhibitory Antibodies

5

Natural
Products

4

Isotope-Labeled Compounds

2

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-128570
    FD-IN-1

    		Complement System Inflammation/Immunology
    FD-IN-1 (Compound 12) is an orally bioavailable and selective factor D (FD) inhibitor with an IC50 of 12 nM. Complement FD, a highly specific S1 serine protease, plays a central role in the alternative complement pathway of the innate immune system. FD-IN-1 also inhibits factor XIa (FXIa) and Tryptase β2 with IC50s of 7.7 and 6.5 µM, respectively .
    FD-IN-1
  • HY-132231
    FD223

    		PI3K Apoptosis Cancer
    FD223 is a potent and selective phosphoinositide 3-kinase delta (PI3Kδ) inhibitor. FD223 displays high potency (IC50=1 nM) and good selectivity over other isoforms (IC50s of 51 nM, 29 nM and 37 nM, respectively for α, β and γ). FD223 exhibits efficient inhibition of the proliferation of acute myeloid leukemia (AML) cell lines by suppressing p-AKT Ser473 thus causing G1 phase arrest during the cell cycle. FD223 has potential for the research of leukemia such as AML .
    FD223
  • HY-133852
    FD-1080

    		Fluorescent Dye Others
    FD-1080 is a fluorophore with both excitation and emission in the NIR-II region (Ex=1064 nm, Em=1080 nm). FD-1080 can be used for in vivo imaging .
    FD-1080
  • HY-133852A
    FD-1080 free acid

    		Fluorescent Dye Others
    FD-1080 free acid is a fluorophore with both excitation and emission in the NIR-II region (Ex=1064 nm, Em=1080 nm). FD-1080 free acid can be used for in vivo imaging .
    FD-1080 free acid
  • HY-N8409
    FD-838

    		Others Others
    FD-838 is a Alkaloids product that can be isolated from the mycelia of the basidiomycete Hericium erinaceum. .
    FD-838
  • HY-D2294
    FD dye 7

    		Fluorescent Dye Others
    FD dye 7 (compound 7) is an intermediate of heptamethacyanine dye fluorescent dye and can be used to synthesize dyes FD-1 and FD-2 .
    FD dye 7
  • HY-155529
    FD1024

    		Pim Cancer
    FD1024 is PIM inhibitor (IC50s: 1.96, 38.9, 4.17 nM for PIM1, 2, 3). FD1024 can be used for research of acute myeloid leukemia. FD1024 has strong antiproliferative activity against the tested AML cell lines, with 0.16 μM, 0.12 μM, 1.05 μM, 1.39μM for EOL-1, MV-4-11, KG-1, MOLM-16 cells. FD1024 also has antitumor efficacy in mice .
    FD1024
  • HY-155066
    FD274

    		PI3K mTOR Cancer
    FD274 is a highly potent PI3K/mTOR dual inhibitor with IC50s of 0.65 nM, 1.57 nM, 0.65 nM, 0.42 nM, and 2.03 nM against PI3Kα/β/γ/δ and mTOR, respectively. FD274 exhibits significant anti-proliferation of AML cell lines (HL-60 and MOLM-16). FD274 demonstrates dose-dependent inhibition of tumor growth in the HL-60 xenograft model. FD274 has the potential for acute myeloid leukemia research .
    FD274
  • HY-155180
    FD2056

    		PI3K Cancer
    FD2056 is a potent and orally active PI3K inhibitor. FD2056 inhibits PI3Kα/PI3Kβ/PI3Kγ/PI3Kδ with IC50s of 0.30, 0.80, 1.10, 0.42 nM. FD2056 also inhibits CDK2-CyclinA2 and CDK4-CyclinD3 with IC50 of 115.95 and 2782.15 nM. FD2056 inhibits breast cancer cell proliferation with IC50s of 1.06, 0.04, 1.40 μM for MDA-MB-231, MDA-MB-468, MCF-7 cells. FD2056 also induces cancer apoptosis and inhibits tumor growth .
    FD2056
  • HY-121503
    FD44

    		Others Neurological Disease
    FD44 is a phenothiazine small molecule that inhibits the interaction between neuronal calcium sensor 1 (NCS-1) and the guanine exchange factor Ric8a, a key regulator of synapse number and neurotransmitter release probability. In the Drosophila genetic autism model of fragile X syndrome (FXS), FD44 restored normal synapse number and associative learning .
    FD44
  • HY-155996
    FD2157

    		PI3K Apoptosis Cancer
    FD2157 is a photosensitive PI3K inhibitor, with IC50s of 43 nM, 83 nM, 84 nM, 14 nM for PI3Kα, PI3Kβ, PI3Kγ, PI3Kδ respectively. FD2157 potently inhibits cancer cell proliferation and induces cell apoptosis when exposed to 365 nm UV light .
    FD2157
  • HY-128685
    FD 12-9

    Ac12Az9

    		 P-glycoprotein BCRP Cancer
    FD 12-9 is a flavonoid dimer, acts as a dual inhibitor of P-gp and BCRP, with EC50s of 285 nM and 0.9 nM, respectively. Anti-glioblastoma activity .
    FD 12-9
  • HY-101748
    Tegadifur

    40497S; FD 1

    		 Others Cancer
    Tegadifur is a fluorine-containing and anti-metabolic agent.
    Tegadifur
  • HY-D0307
    Amaranth free acid

    Acid Red 27 free acid; Azorubin S free acid; FD & C Red Dye No. 2 free acid

    		 Fluorescent Dye Others
    Amaranth free acid (Acid Red 27 free acid; Azorubin S free acid; FD & C Red Dye No. 2 free acid) is a multifunctional dye. Dyes are important tools in biological experiments. They can help researchers observe and analyze cell structures, track biomolecules, evaluate cell functions, distinguish cell types, detect biomolecules, study tissue pathology and monitor microorganisms. Their applications range from basic scientific research to clinical A wide range of diagnostics. Dyes are also widely used in traditional fields such as textile dyeing, as well as in emerging fields such as functional textile processing, food pigments and dye-sensitized solar cells.
    Amaranth free acid
  • HY-111223
    Tralkoxydim

    PP604; ICIA 0604; FD-4026

    		 Acetyl-CoA Carboxylase Others
    Tralkoxydim is a cyclohexanedione herbicide that inhibits Acetyl-CoA Carboxylase in corn .
    Tralkoxydim
  • HY-D0257
    Tartrazine
    1 Publications Verification

    Acid Yellow 23; FD&C Yellow No. 5

    		 Fluorescent Dye Others
    Tartrazine is an azo acid dye, orange-yellow powder, soluble in water and turns yellow. It is mainly used as a synthetic lemon yellow azo dye for food coloring. It is the most stable colorant.
    Tartrazine
  • HY-123630
    Allura Red AC

    FD&C RED NO. 40; CI 16035

    		 Fluorescent Dye Others
    Allura Red AC, a food colourant, is dark red and water-soluble powder or granules used in various applications, such as in drinks, syrups, sweets and cereals. Allura Red AC has the ability to quench the intrinsic fluorescence of HSA through static quenching .
    Allura Red AC
  • HY-D0307A
    Amaranth

    Acid Red 27; Azorubin S; FD & C Red Dye No. 2

    		 Fluorescent Dye Others
    Amaranth is a dark red to purple azo dye used as a food dye and cosmetics. Amaranth is an anionic dye that can be applied to natural and synthetic fibers, leather, paper, and phenol-formaldehyde resins.
    Amaranth
  • HY-D0915
    Brilliant Blue FCF
    2 Publications Verification

    Acid Blue 9; FD&C Blue No. 1; E133

    		 Fluorescent Dye Others
    Brilliant Blue FCF is an aromatic hydrocarbon, a synthetic dye produced from petroleum and used as a colorant for food and other substances. The solution has a maximum absorption at 628 nm.
    Brilliant Blue FCF
  • HY-D0914
    Fast Green FCF

    FD&C Green No. 3; Food green 3; C.I. 42053

    		 Fluorescent Dye Others
    Fast Green FCF is a sea green triarylmethane food dye, with absorption maximum ranging from 622 to 626 nm. Fast Green FCF is widely used as a staining agent like quantitative stain for histones at alkaline pH after acid extraction of DNA, and as a protein stain in electrophoresis. Fast Green FCF is carcinogenic and acts as a presynaptic locus by inhibiting the release of neurotransmitters in the nervous system .
    Fast Green FCF
  • HY-148171
    L-2'-Fd4C

    		HIV HBV DNA/RNA Synthesis Nucleoside Antimetabolite/Analog Infection
    L-2'-Fd4C, is an l-nucleoside analogue. L-2'-Fd4C has anti-human immunodeficiency virus (HIV) and anti-hepatitis B virus (HBV) activity .
    L-2'-Fd4C
  • HY-148172
    L-Fd4A

    		HIV HBV Nucleoside Antimetabolite/Analog Infection
    L-Fd4A is an adenine derivative. L-Fd4A has anti-human immunodeficiency virus (HIV) (EC50=1.5 μM) and anti-hepatitis B virus (HBV) (EC50=1.7 μM) activity. L-Fd4A has low cytotoxicity .
    L-Fd4A
  • HY-N3921
    Gancaonin I

    		Carboxylesterase Cancer
    Gancaonin I, an Isoflavone, exhibits moderate inhibition on human carboxylesterase 2 (hCES2A) with IC50 of 1.72 μM. Gancaonin I inhibits hCES2A-mediated fluorescein diacetate (FD) hydrolysis .
    Gancaonin I
  • HY-N3329
    Magnoloside A

    		Others Others
    Magnoloside A (compound 4) is a main phenylethanoid glycoside in Houpo. Magnoloside A can be used in the research of functional dyspepsia (FD) .
    Magnoloside A
  • HY-N0756
    Bornyl acetate

    		Apoptosis Cancer
    Bornyl acetate is a potent odorant, exhibiting one of the highest flavor dilution factor (FD factor). Bornyl acetate possesses anti-cancer activity .
    Bornyl acetate
  • HY-13631AS1
    Exatecan-d3 mesylate

    DX8951f-d3 mesylate

    		 Topoisomerase ADC Cytotoxin Isotope-Labeled Compounds Cancer
    Exatecan-d3 (DX8951f-d3) mesylate is deuterium-labeled Exatecan (mesylate) (HY-13631A) .
    Exatecan-d3 mesylate
  • HY-B2195
    Aldioxa

    		Others Metabolic Disease
    Aidioxa has the ability to improve delayed gastric emptying in rats. It can partially improve delayed gastric emptying caused by clonidine or restraint stress. The allyltoin part of Aidioxa restores gastric emptying activity by antagonizing α-2 adrenergic receptors. Its aluminum hydroxide part is involved in restoring gastric compliance. Aidioxa can improve both delayed gastric emptying and impaired gastric compliance, both of which play an important role in functional dyspepsia (FD). Aidioxa is a candidate agent for inhibiting FD.
    Aldioxa
  • HY-139588
    Vemircopan

    ALXN2050; ACH 0145228; ACH-5228

    		 Complement System Metabolic Disease Inflammation/Immunology
    Vemircopan (ALXN2050) is an orally active complement factor D inhibitor. Vemircopan is promising for research of paroxysmal nocturnal hemoglobinuria .
    Vemircopan
  • HY-134178S1
    5-Fluorouridine 5'-triphosphate-13C,19F,d1

    		Isotope-Labeled Compounds Others
    5-Fluorouridine 5'-triphosphate- 13C, 19F,d1 is deuterium and 13C-labeled 5-Fluorouridine 5'-triphosphate (HY-134178).
    5-Fluorouridine 5'-triphosphate-13C,19F,d1
  • HY-N0756R
    Bornyl acetate (Standard)

    		Apoptosis Cancer
    Bornyl acetate (Standard) is the analytical standard of Bornyl acetate. This product is intended for research and analytical applications. Bornyl acetate is a potent odorant, exhibiting one of the highest flavor dilution factor (FD factor). Bornyl acetate possesses anti-cancer activity .
    Bornyl acetate (Standard)
  • HY-102034
    Complement factor D-IN-1

    		Complement System Inflammation/Immunology
    Complement factor D-IN-1 is a potent and selective small-molecule reversible factor d inhibitor, with IC50s of 0.006 and 0.05 μM in FD Thioesterolytic Fluorescent Assay and a MAC Deposition Assay, respectively.
    Complement factor D-IN-1
  • HY-B2089
    Cinitapride

    		5-HT Receptor Dopamine Receptor Neurological Disease Metabolic Disease
    Cinitapride is a nonselective 5-HT1 and 5-HT4 receptors agonist and a 5-HT2 and D2 antagonist. Cinitapride can be used in functional dyspepsia (FD) and gastroesophageal reflux disease (GERD) research .
    Cinitapride
  • HY-122700
    Factor D inhibitor 6

    		Complement System Inflammation/Immunology
    Factor D inhibitor 6 is a potent, highly selective and orally active factor D (FD) inhibitor with an IC50 of 30 nM and a Kd of 6 nM. Factor D inhibitor 6 is inactive against factor B, lassical and lectin complement-pathway activation, and a broad assay panel of receptors, ion channels, kinases and proteases .
    Factor D inhibitor 6
  • HY-B2089R
    Cinitapride (Standard)

    		5-HT Receptor Dopamine Receptor Neurological Disease Metabolic Disease
    Cinitapride (Standard) is the analytical standard of Cinitapride. This product is intended for research and analytical applications. Cinitapride is a nonselective 5-HT1 and 5-HT4 receptors agonist and a 5-HT2 and D2 antagonist. Cinitapride can be used in functional dyspepsia (FD) and gastroesophageal reflux disease (GERD) research .
    Cinitapride (Standard)
  • HY-15583S
    Auristatin F-d8

    		Isotope-Labeled Compounds ADC Cytotoxin Microtubule/Tubulin Cancer
    Auristatin F-d8 is deuterium labeled Auristatin F (HY-15583). Auristatin F is a potent cytotoxin in antibo-conjugated agents and an analogue of MMAF. Auristatin F is a potent microtubule inhibitor and vascular damaging agent (VDA). Auristatin F inhibits cell division by preventing tubulin aggregation.Auristatin F can be used in antibody-drug conjugates (ADC) .
    Auristatin F-d8
  • HY-14648S5
    Dexamethasone-d3-1

    Hexadecadrol-d3-1; Prednisolone F-d3-1

    		 Isotope-Labeled Compounds Cancer
    Dexamethasone-d3-1 (Hexadecadrol-d3-1; Prednisolone F-d3-1) is a deuterium labeled Dexamethasone (HY-14648). Dexamethasone (Hexadecadrol) is a glucocorticoid receptor agonist. Dexamethasone also significantly decreases CD11b, CD18, and CD62L expression on neutrophils, and CD11b and CD18 expression on monocytes. Dexamethasone is highly effective in the control of COVID-19 infection. Dexamethasone inhibits production of exosomes containing inflammatory microRNA-155 in lipopolysaccharide-induced macrophage inflammatory responses.
    Dexamethasone-d3-1

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