2. PI3K/Akt/mTOR
  3. PI3K mTOR
  4. FD274

FD274 is a highly potent PI3K/mTOR dual inhibitor with IC50s of 0.65 nM, 1.57 nM, 0.65 nM, 0.42 nM, and 2.03 nM against PI3Kα/β/γ/δ and mTOR, respectively. FD274 exhibits significant anti-proliferation of AML cell lines (HL-60 and MOLM-16). FD274 demonstrates dose-dependent inhibition of tumor growth in the HL-60 xenograft model. FD274 has the potential for acute myeloid leukemia research.

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FD274 Chemical Structure

FD274 Chemical Structure

CAS No. : 2641899-38-7

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FD274 Related Antibodies

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PI3Kα PI3Kβ PI3Kγ PI3Kδ PI3KC2α PI3KC2β PI3KC2γ Vps34 PI3K PI3KC3 p120γ

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mTOR mTORC1 mTORC2

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Description

FD274 is a highly potent PI3K/mTOR dual inhibitor with IC50s of 0.65 nM, 1.57 nM, 0.65 nM, 0.42 nM, and 2.03 nM against PI3Kα/β/γ/δ and mTOR, respectively. FD274 exhibits significant anti-proliferation of AML cell lines (HL-60 and MOLM-16). FD274 demonstrates dose-dependent inhibition of tumor growth in the HL-60 xenograft model. FD274 has the potential for acute myeloid leukemia research[1].

IC50 & Target[1]

PI3Kα

0.65 nM (IC50)

PI3Kβ

1.57 nM (IC50)

PI3Kδ

0.65 nM (IC50)

PI3Kγ

0.42 nM (IC50)

mTOR

2.03 nM (IC50)

Molecular Weight

480.90

Formula

C22H14ClFN6O2S
CAS No.
SMILES

ClC1=NC=C(C2=CN=C(NN=C3C4=CC=NC=C4)C3=C2)C=C1NS(=O)(C5=CC=C(F)C=C5)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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FD274 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

FD2742641899-38-7FD 274FD-274PI3KmTORPhosphoinositide 3-kinaseMammalian target of Rapamycinacute myeloid leukemiaanti-proliferationAMLHL-60MOLM-16Inhibitorinhibitorinhibit

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