2. PI3K/Akt/mTOR
  3. PI3K mTOR
  4. FD274

FD274 is a highly potent PI3K/mTOR dual inhibitor with IC50s of 0.65 nM, 1.57 nM, 0.65 nM, 0.42 nM, and 2.03 nM against PI3Kα/β/γ/δ and mTOR, respectively. FD274 exhibits significant anti-proliferation of AML cell lines (HL-60 and MOLM-16). FD274 demonstrates dose-dependent inhibition of tumor growth in the HL-60 xenograft model. FD274 has the potential for acute myeloid leukemia research.

For research use only. We do not sell to patients.

FD274 Chemical Structure

FD274 Chemical Structure

CAS No. : 2641899-38-7

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10 mg USD 499 In-stock
25 mg USD 999 In-stock
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Based on 1 publication(s) in Google Scholar

FD274 Related Antibodies

Top Publications Citing Use of Products

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mTOR mTORC1 mTORC2

  • Biological Activity

  • Purity & Documentation

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Description

FD274 is a highly potent PI3K/mTOR dual inhibitor with IC50s of 0.65 nM, 1.57 nM, 0.65 nM, 0.42 nM, and 2.03 nM against PI3Kα/β/γ/δ and mTOR, respectively. FD274 exhibits significant anti-proliferation of AML cell lines (HL-60 and MOLM-16). FD274 demonstrates dose-dependent inhibition of tumor growth in the HL-60 xenograft model. FD274 has the potential for acute myeloid leukemia research[1].

IC50 & Target[1]

PI3Kα

0.65 nM (IC50)

PI3Kβ

1.57 nM (IC50)

PI3Kδ

0.65 nM (IC50)

PI3Kγ

0.42 nM (IC50)

mTOR

2.03 nM (IC50)

Molecular Weight

480.90

Formula

C22H14ClFN6O2S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

ClC1=NC=C(C2=CN=C(NN=C3C4=CC=NC=C4)C3=C2)C=C1NS(=O)(C5=CC=C(F)C=C5)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (259.93 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0794 mL 10.3972 mL 20.7943 mL
5 mM 0.4159 mL 2.0794 mL 4.1589 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

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Volume (start)

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Concentration (final)

C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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g

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.0794 mL 10.3972 mL 20.7943 mL 51.9859 mL
5 mM 0.4159 mL 2.0794 mL 4.1589 mL 10.3972 mL
10 mM 0.2079 mL 1.0397 mL 2.0794 mL 5.1986 mL
15 mM 0.1386 mL 0.6931 mL 1.3863 mL 3.4657 mL
20 mM 0.1040 mL 0.5199 mL 1.0397 mL 2.5993 mL
25 mM 0.0832 mL 0.4159 mL 0.8318 mL 2.0794 mL
30 mM 0.0693 mL 0.3466 mL 0.6931 mL 1.7329 mL
40 mM 0.0520 mL 0.2599 mL 0.5199 mL 1.2996 mL
50 mM 0.0416 mL 0.2079 mL 0.4159 mL 1.0397 mL
60 mM 0.0347 mL 0.1733 mL 0.3466 mL 0.8664 mL
80 mM 0.0260 mL 0.1300 mL 0.2599 mL 0.6498 mL
100 mM 0.0208 mL 0.1040 mL 0.2079 mL 0.5199 mL
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FD274 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

FD2742641899-38-7FD 274FD-274PI3KmTORPhosphoinositide 3-kinaseMammalian target of Rapamycinacute myeloid leukemiaanti-proliferationAMLHL-60MOLM-16Inhibitorinhibitorinhibit

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